TY - JOUR
T1 - Soft Robotics Programmed with Double Crosslinking DNA Hydrogels
AU - Zhao, Zhi
AU - Wang, Chao
AU - Yan, Hao
AU - Liu, Yan
N1 - Funding Information:
This work was supported by an Army Research Office MURI (Award No. W911NF-12-1-0420) to H.Y. H.Y. was also supported by the Presidential Strategic Initiative Fund from Arizona State University.
Publisher Copyright:
© 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
PY - 2019/11/1
Y1 - 2019/11/1
N2 - DNA nanotechnology is developed for decades to construct dynamic responsive systems in optics, quantum electronics, and therapeutics. While DNA nanotechnology is a powerful tool in nanomaterials, it is rare to see successful applications of DNA molecules in the macroscopic regime of material sciences. Here, a novel strategy to magnify the nanometer scale DNA self-assembly into a macroscopic mechanical responsiveness is demonstrated. By incorporating molecularly engineered DNA sequences into a polymeric network, a new type of responsive hydrogel (D-gel), whose overall morphology is dynamically controlled by DNA hybridization-induced double crosslinking is able to be created. As a step toward manufacturing, the D-gel in combination with a bottom-up 3D printing technology is employed to rapidly create modular macroscopic structures that feature programmable reconfiguration and directional movement, which can even mimic the complex gestures of human hands. Mechanical operations such as catch and release are demonstrated by a proof-of-concept hydrogel palm, which possessed great promise for future engineering applications. Compared with previously developed DNA hydrogels, the D-gel features an ease of synthesis, faster response, and a high degree of programmable control. Moreover, it is possible to scale up the production of D-gel containing responsive devices through direct 3D printing.
AB - DNA nanotechnology is developed for decades to construct dynamic responsive systems in optics, quantum electronics, and therapeutics. While DNA nanotechnology is a powerful tool in nanomaterials, it is rare to see successful applications of DNA molecules in the macroscopic regime of material sciences. Here, a novel strategy to magnify the nanometer scale DNA self-assembly into a macroscopic mechanical responsiveness is demonstrated. By incorporating molecularly engineered DNA sequences into a polymeric network, a new type of responsive hydrogel (D-gel), whose overall morphology is dynamically controlled by DNA hybridization-induced double crosslinking is able to be created. As a step toward manufacturing, the D-gel in combination with a bottom-up 3D printing technology is employed to rapidly create modular macroscopic structures that feature programmable reconfiguration and directional movement, which can even mimic the complex gestures of human hands. Mechanical operations such as catch and release are demonstrated by a proof-of-concept hydrogel palm, which possessed great promise for future engineering applications. Compared with previously developed DNA hydrogels, the D-gel features an ease of synthesis, faster response, and a high degree of programmable control. Moreover, it is possible to scale up the production of D-gel containing responsive devices through direct 3D printing.
KW - 3D printing
KW - DNA hydrogel
KW - doubling crosslink
KW - programmable control
KW - soft robotics
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U2 - 10.1002/adfm.201905911
DO - 10.1002/adfm.201905911
M3 - Article
AN - SCOPUS:85071762008
SN - 1616-301X
VL - 29
JO - Advanced Functional Materials
JF - Advanced Functional Materials
IS - 45
M1 - 1905911
ER -