Social context has differential effects on acquisition of nicotine self-administration in male and female rats

Natalie A. Peartree, Kayla N. Hatch, Julianna G. Goenaga, Nora R. Dado, Hanna Molla, Martin A. Dufwenberg, Allegra Campagna, Rachel Mendoza, Timothy H C Cheung, Joshua S. Talboom, Janet Neisewander

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Rational: Smoking typically begins during adolescence or early adulthood in a social context, yet the role of social context in animal models is poorly understood. Objectives: The present study examined the effect of social context on acquisition of nicotine self-administration. Methods: Sixty-day-old male and female Sprague-Dawley rats were trained to press a lever for nicotine (0.015 mg/kg, IV) or saline infusions (males only) on a fixed ratio (FR1) schedule of reinforcement across nine sessions in duplex chambers that were conjoined with either a solid wall or a wall containing wire mesh creating a social context between rat dyads (social visual, auditory, and olfactory cues). In a subsequent experiment, sex differences and dose-dependent effects of nicotine [0 (saline), 0.015 or 0.03 mg/kg, IV] were directly compared in rats trained in the isolated or social context on a schedule progressing from FR1 to FR3. These rats were given 20 sessions followed by 3 extinction sessions. Results: We consistently found transient social facilitation of low-dose nicotine self-administration in males during the first session. However, across training overall, we found social suppression of nicotine intake that was most prominent in females during later sessions. Conclusions: Collectively, these findings suggest that at the age of transition from adolescence to adulthood, a social context enhances the initial reinforcing effects of nicotine in males, but protects against nicotine intake during later sessions especially in females. These findings highlight the importance of sex and social context in studying neural mechanisms involved in initiation of nicotine use.

Original languageEnglish (US)
Pages (from-to)1-14
Number of pages14
JournalPsychopharmacology
DOIs
StateAccepted/In press - Mar 31 2017

Fingerprint

Self Administration
Nicotine
Social Facilitation
Reinforcement Schedule
Sex Characteristics
Cues
Sprague Dawley Rats
Appointments and Schedules
Animal Models
Smoking

Keywords

  • Adolescence
  • Dose-response
  • Drug self-administration
  • Extinction
  • Sex differences
  • Social behavior

ASJC Scopus subject areas

  • Pharmacology

Cite this

Social context has differential effects on acquisition of nicotine self-administration in male and female rats. / Peartree, Natalie A.; Hatch, Kayla N.; Goenaga, Julianna G.; Dado, Nora R.; Molla, Hanna; Dufwenberg, Martin A.; Campagna, Allegra; Mendoza, Rachel; Cheung, Timothy H C; Talboom, Joshua S.; Neisewander, Janet.

In: Psychopharmacology, 31.03.2017, p. 1-14.

Research output: Contribution to journalArticle

Peartree, NA, Hatch, KN, Goenaga, JG, Dado, NR, Molla, H, Dufwenberg, MA, Campagna, A, Mendoza, R, Cheung, THC, Talboom, JS & Neisewander, J 2017, 'Social context has differential effects on acquisition of nicotine self-administration in male and female rats', Psychopharmacology, pp. 1-14. https://doi.org/10.1007/s00213-017-4590-0
Peartree, Natalie A. ; Hatch, Kayla N. ; Goenaga, Julianna G. ; Dado, Nora R. ; Molla, Hanna ; Dufwenberg, Martin A. ; Campagna, Allegra ; Mendoza, Rachel ; Cheung, Timothy H C ; Talboom, Joshua S. ; Neisewander, Janet. / Social context has differential effects on acquisition of nicotine self-administration in male and female rats. In: Psychopharmacology. 2017 ; pp. 1-14.
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abstract = "Rational: Smoking typically begins during adolescence or early adulthood in a social context, yet the role of social context in animal models is poorly understood. Objectives: The present study examined the effect of social context on acquisition of nicotine self-administration. Methods: Sixty-day-old male and female Sprague-Dawley rats were trained to press a lever for nicotine (0.015 mg/kg, IV) or saline infusions (males only) on a fixed ratio (FR1) schedule of reinforcement across nine sessions in duplex chambers that were conjoined with either a solid wall or a wall containing wire mesh creating a social context between rat dyads (social visual, auditory, and olfactory cues). In a subsequent experiment, sex differences and dose-dependent effects of nicotine [0 (saline), 0.015 or 0.03 mg/kg, IV] were directly compared in rats trained in the isolated or social context on a schedule progressing from FR1 to FR3. These rats were given 20 sessions followed by 3 extinction sessions. Results: We consistently found transient social facilitation of low-dose nicotine self-administration in males during the first session. However, across training overall, we found social suppression of nicotine intake that was most prominent in females during later sessions. Conclusions: Collectively, these findings suggest that at the age of transition from adolescence to adulthood, a social context enhances the initial reinforcing effects of nicotine in males, but protects against nicotine intake during later sessions especially in females. These findings highlight the importance of sex and social context in studying neural mechanisms involved in initiation of nicotine use.",
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AU - Dado, Nora R.

AU - Molla, Hanna

AU - Dufwenberg, Martin A.

AU - Campagna, Allegra

AU - Mendoza, Rachel

AU - Cheung, Timothy H C

AU - Talboom, Joshua S.

AU - Neisewander, Janet

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N2 - Rational: Smoking typically begins during adolescence or early adulthood in a social context, yet the role of social context in animal models is poorly understood. Objectives: The present study examined the effect of social context on acquisition of nicotine self-administration. Methods: Sixty-day-old male and female Sprague-Dawley rats were trained to press a lever for nicotine (0.015 mg/kg, IV) or saline infusions (males only) on a fixed ratio (FR1) schedule of reinforcement across nine sessions in duplex chambers that were conjoined with either a solid wall or a wall containing wire mesh creating a social context between rat dyads (social visual, auditory, and olfactory cues). In a subsequent experiment, sex differences and dose-dependent effects of nicotine [0 (saline), 0.015 or 0.03 mg/kg, IV] were directly compared in rats trained in the isolated or social context on a schedule progressing from FR1 to FR3. These rats were given 20 sessions followed by 3 extinction sessions. Results: We consistently found transient social facilitation of low-dose nicotine self-administration in males during the first session. However, across training overall, we found social suppression of nicotine intake that was most prominent in females during later sessions. Conclusions: Collectively, these findings suggest that at the age of transition from adolescence to adulthood, a social context enhances the initial reinforcing effects of nicotine in males, but protects against nicotine intake during later sessions especially in females. These findings highlight the importance of sex and social context in studying neural mechanisms involved in initiation of nicotine use.

AB - Rational: Smoking typically begins during adolescence or early adulthood in a social context, yet the role of social context in animal models is poorly understood. Objectives: The present study examined the effect of social context on acquisition of nicotine self-administration. Methods: Sixty-day-old male and female Sprague-Dawley rats were trained to press a lever for nicotine (0.015 mg/kg, IV) or saline infusions (males only) on a fixed ratio (FR1) schedule of reinforcement across nine sessions in duplex chambers that were conjoined with either a solid wall or a wall containing wire mesh creating a social context between rat dyads (social visual, auditory, and olfactory cues). In a subsequent experiment, sex differences and dose-dependent effects of nicotine [0 (saline), 0.015 or 0.03 mg/kg, IV] were directly compared in rats trained in the isolated or social context on a schedule progressing from FR1 to FR3. These rats were given 20 sessions followed by 3 extinction sessions. Results: We consistently found transient social facilitation of low-dose nicotine self-administration in males during the first session. However, across training overall, we found social suppression of nicotine intake that was most prominent in females during later sessions. Conclusions: Collectively, these findings suggest that at the age of transition from adolescence to adulthood, a social context enhances the initial reinforcing effects of nicotine in males, but protects against nicotine intake during later sessions especially in females. These findings highlight the importance of sex and social context in studying neural mechanisms involved in initiation of nicotine use.

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