Smooth muscle cell phenotype modulation due to compressive loading

J. Woodell, Stephen Massia, E. Langan, M. LaBerge

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The phenotype transition of the smooth muscle cells (SMC) under compressive loading is analyzed as seen from angioplasty and endovascular stenting. In cell culture, the cells are in their synthetic phenotype and exhibit a high absorbance. As the cells start to experience compressive loading, they become less proliferative. The cells are damaged once they experience a pressure of around 7 psi. One of the mechanisms for mechanotransduction in the cells are the integrins. They transfer mechanical load signals into cell and then through secondary messengers, DNA synthesis is initiated. Future work to verify phenotype change includes nuclear and cytoskeletal markers as well as integrin assays.

Original languageEnglish (US)
Title of host publicationSouthern Biomedical Engineering Conference - Proceedings
Place of PublicationPiscataway, NJ, United States
PublisherIEEE
Pages12
Number of pages1
StatePublished - 1998
Externally publishedYes
EventProceedings of the 1998 17th Southern Biomedical Engineering Conference - San Antonio, TX, USA
Duration: Feb 6 1998Feb 8 1998

Other

OtherProceedings of the 1998 17th Southern Biomedical Engineering Conference
CitySan Antonio, TX, USA
Period2/6/982/8/98

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ASJC Scopus subject areas

  • Engineering(all)

Cite this

Woodell, J., Massia, S., Langan, E., & LaBerge, M. (1998). Smooth muscle cell phenotype modulation due to compressive loading. In Southern Biomedical Engineering Conference - Proceedings (pp. 12). IEEE.