Small HIV-1-Tat peptides inhibit HIV replication in cultured T-cells

Marianne Löhr, Karen V. Kibler, Ian Zachary, Kuan Teh Jeang, David L. Selwood

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

Full-length soluble HIV-1 Tat protein has been shown to bind the CXCR4 receptor. Occupancy of CXCR4 by Tat inhibits infection of cells by T-tropic HIV-1. To understand if fragments of the Tat protein may have similar anti-HIV activity, we synthesized Tat peptides and tested their activity in tissue culture. Here, we report a sequence-specific contribution of Tat residues 31-35 to anti-HIV-1 activity.

Original languageEnglish (US)
Pages (from-to)609-613
Number of pages5
JournalBiochemical and Biophysical Research Communications
Volume300
Issue number2
DOIs
StatePublished - Jan 10 2003
Externally publishedYes

Keywords

  • Chemokine receptor
  • Cyclic peptide
  • Human immunodeficiency virus
  • Tat protein

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

Fingerprint Dive into the research topics of 'Small HIV-1-Tat peptides inhibit HIV replication in cultured T-cells'. Together they form a unique fingerprint.

  • Cite this