Small HIV-1-Tat peptides inhibit HIV replication in cultured T-cells

Marianne Löhr; Karen V. Kibler; Ian Zachary; Kuan Teh Jeang; David L. Selwood

doi:10.1016/S0006-291X(02)02903-0

Small HIV-1-Tat peptides inhibit HIV replication in cultured T-cells

Marianne Löhr, Karen V. Kibler, Ian Zachary, Kuan Teh Jeang, David L. Selwood

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Full-length soluble HIV-1 Tat protein has been shown to bind the CXCR4 receptor. Occupancy of CXCR4 by Tat inhibits infection of cells by T-tropic HIV-1. To understand if fragments of the Tat protein may have similar anti-HIV activity, we synthesized Tat peptides and tested their activity in tissue culture. Here, we report a sequence-specific contribution of Tat residues 31-35 to anti-HIV-1 activity.

Original language	English (US)
Pages (from-to)	609-613
Number of pages	5
Journal	Biochemical and Biophysical Research Communications
Volume	300
Issue number	2
DOIs	https://doi.org/10.1016/S0006-291X(02)02903-0
State	Published - Jan 10 2003
Externally published	Yes

Keywords

Chemokine receptor
Cyclic peptide
Human immunodeficiency virus
Tat protein

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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10.1016/S0006-291X(02)02903-0

Cite this

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title = "Small HIV-1-Tat peptides inhibit HIV replication in cultured T-cells",

abstract = "Full-length soluble HIV-1 Tat protein has been shown to bind the CXCR4 receptor. Occupancy of CXCR4 by Tat inhibits infection of cells by T-tropic HIV-1. To understand if fragments of the Tat protein may have similar anti-HIV activity, we synthesized Tat peptides and tested their activity in tissue culture. Here, we report a sequence-specific contribution of Tat residues 31-35 to anti-HIV-1 activity.",

keywords = "Chemokine receptor, Cyclic peptide, Human immunodeficiency virus, Tat protein",

author = "Marianne L{\"o}hr and Kibler, {Karen V.} and Ian Zachary and Jeang, {Kuan Teh} and Selwood, {David L.}",

note = "Funding Information: This work was supported, in part, by Ark Therapeutics Ltd. I.Z. is supported by BHF Grant BS/94001. We thank Shaheda Shaikh for technical assistance. Copyright: Copyright 2008 Elsevier B.V., All rights reserved.",

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T1 - Small HIV-1-Tat peptides inhibit HIV replication in cultured T-cells

AU - Löhr, Marianne

AU - Kibler, Karen V.

AU - Zachary, Ian

AU - Jeang, Kuan Teh

AU - Selwood, David L.

N1 - Funding Information: This work was supported, in part, by Ark Therapeutics Ltd. I.Z. is supported by BHF Grant BS/94001. We thank Shaheda Shaikh for technical assistance. Copyright: Copyright 2008 Elsevier B.V., All rights reserved.

PY - 2003/1/10

Y1 - 2003/1/10

N2 - Full-length soluble HIV-1 Tat protein has been shown to bind the CXCR4 receptor. Occupancy of CXCR4 by Tat inhibits infection of cells by T-tropic HIV-1. To understand if fragments of the Tat protein may have similar anti-HIV activity, we synthesized Tat peptides and tested their activity in tissue culture. Here, we report a sequence-specific contribution of Tat residues 31-35 to anti-HIV-1 activity.

AB - Full-length soluble HIV-1 Tat protein has been shown to bind the CXCR4 receptor. Occupancy of CXCR4 by Tat inhibits infection of cells by T-tropic HIV-1. To understand if fragments of the Tat protein may have similar anti-HIV activity, we synthesized Tat peptides and tested their activity in tissue culture. Here, we report a sequence-specific contribution of Tat residues 31-35 to anti-HIV-1 activity.

KW - Chemokine receptor

KW - Cyclic peptide

KW - Human immunodeficiency virus

KW - Tat protein

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Small HIV-1-Tat peptides inhibit HIV replication in cultured T-cells

Abstract

Keywords

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