Small HIV-1-Tat peptides inhibit HIV replication in cultured T-cells

Marianne Löhr, Karen Kibler, Ian Zachary, Kuan Teh Jeang, David L. Selwood

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Full-length soluble HIV-1 Tat protein has been shown to bind the CXCR4 receptor. Occupancy of CXCR4 by Tat inhibits infection of cells by T-tropic HIV-1. To understand if fragments of the Tat protein may have similar anti-HIV activity, we synthesized Tat peptides and tested their activity in tissue culture. Here, we report a sequence-specific contribution of Tat residues 31-35 to anti-HIV-1 activity.

Original languageEnglish (US)
Pages (from-to)609-613
Number of pages5
JournalBiochemical and Biophysical Research Communications
Volume300
Issue number2
DOIs
StatePublished - Jan 10 2003
Externally publishedYes

Fingerprint

tat Gene Products
T-cells
HIV-1
Cultured Cells
HIV
CXCR4 Receptors
T-Lymphocytes
Tropics
Tissue culture
Peptides
Human Immunodeficiency Virus tat Gene Products
Cells
Infection

Keywords

  • Chemokine receptor
  • Cyclic peptide
  • Human immunodeficiency virus
  • Tat protein

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

Small HIV-1-Tat peptides inhibit HIV replication in cultured T-cells. / Löhr, Marianne; Kibler, Karen; Zachary, Ian; Jeang, Kuan Teh; Selwood, David L.

In: Biochemical and Biophysical Research Communications, Vol. 300, No. 2, 10.01.2003, p. 609-613.

Research output: Contribution to journalArticle

Löhr, Marianne ; Kibler, Karen ; Zachary, Ian ; Jeang, Kuan Teh ; Selwood, David L. / Small HIV-1-Tat peptides inhibit HIV replication in cultured T-cells. In: Biochemical and Biophysical Research Communications. 2003 ; Vol. 300, No. 2. pp. 609-613.
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