Site-specific (targeted) drug delivery in cancer therapy

George Poste, R. Kirsh

Research output: Contribution to journalArticle

114 Citations (Scopus)

Abstract

The current status of efforts to target cytotoxic agents to tumor cells using antitumor antibodies and particulate drug carriers such as liposomes and microspheres is reviewed. Emphasis is given to the role of anatomic and physiologic factors in determining the disposition, fate and therapeutic efficacy of targeted drug delivery systems and to the importance of tumor cell heterogeneity as a major obstacle to effective cancer therapy.

Original languageEnglish (US)
Pages (from-to)869-878
Number of pages10
JournalBio/Technology
Volume1
Issue number10
StatePublished - 1983
Externally publishedYes

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Tumors
Cells
Drug Carriers
Liposomes
Cytotoxins
Microspheres
Antibodies
Pharmaceutical Preparations
Neoplasms
Drug Delivery Systems
Therapeutics
Targeted drug delivery

ASJC Scopus subject areas

  • Biotechnology

Cite this

Site-specific (targeted) drug delivery in cancer therapy. / Poste, George; Kirsh, R.

In: Bio/Technology, Vol. 1, No. 10, 1983, p. 869-878.

Research output: Contribution to journalArticle

Poste, G & Kirsh, R 1983, 'Site-specific (targeted) drug delivery in cancer therapy', Bio/Technology, vol. 1, no. 10, pp. 869-878.
Poste, George ; Kirsh, R. / Site-specific (targeted) drug delivery in cancer therapy. In: Bio/Technology. 1983 ; Vol. 1, No. 10. pp. 869-878.
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