Site-specific (targeted) drug delivery in cancer therapy

George Poste, Richard Kirsh

Research output: Contribution to journalArticle

121 Scopus citations

Abstract

The current status of efforts to target cytotoxic agents to tumor cells using antitumor antibodies and particulate drug carriers such as liposomes and microspheres is reviewed. Emphasis is given to the role of anatomic and physiologic factors in determining the disposition, fate, and therapeutic efficacy of targeted drug delivery systems and to the importance of tumor cell heterogeneity as a major obstacle to effective cancer therapy.

Original languageEnglish (US)
Pages (from-to)869-878
Number of pages10
JournalBio/Technology
Volume1
Issue number10
DOIs
StatePublished - Dec 1983
Externally publishedYes

ASJC Scopus subject areas

  • Biotechnology

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