Sirolimus with neoral versus mycophenolate mofetil with neoral is associated with decreased renal allograft survival

Herwig Ulf Meier-Kriesche, Bettina J. Steffen, Alice H. Chu, Jacqueline J. Loveland, Robert D. Gordon, Jonathan A. Morris, Bruce Kaplan

    Research output: Contribution to journalArticlepeer-review

    62 Scopus citations

    Abstract

    To evaluate the association between a regimen of cyclosporine microemulsion (CsA) + sirolimus (Rapa) treatment versus CsA and mycophenolate mofetil (MMF) and renal allograft survival, we analyzed 23 016 primary recipients reported to the Scientific Registry of Transplant Recipients between January 1, 1998 and July 26, 2003. Univariate Kaplan-Meier analysis and multivariate Cox proportional hazard models correcting for demographic and clinical covariates were used to estimate the relative risks for CsA+Rapa versus CsA+MMF-treated patients reaching study endpoints. Subgroup analyses were conducted for recipient ethnicity and donor type. CsA+Rapa was associated with significantly lower graft survival (74.6% vs. 79.3% at 4 years, p = 0.002) and death-censored graft survival (83.7% vs. 87.2%, p = 0.003) compared to CsA+MMF. In multivariate analyses, CsA+Rapa was associated with a significantly increased risk for graft loss, death-censored graft loss and decline in renal function (HR = 1.22, p = 0.002; HR = 1.22, p = 0.018 and HR = 1.25, p < 0.001, respectively). Similar results were obtained in recipient ethnicity and donor type subgroups. In summary, CsA+Rapa was associated with significantly worse graft survival and death-censored graft survival compared to CsA+MMF, and likely reflects full-dose CsA+Rapa. Outcomes regarding alternative strategies of Rapa utilization with reduced CsA, with alternative agents or with no calcineurin inhibitor cannot be extrapolated from these data.

    Original languageEnglish (US)
    Pages (from-to)2058-2066
    Number of pages9
    JournalAmerican Journal of Transplantation
    Volume4
    Issue number12
    DOIs
    StatePublished - Dec 2004

    Keywords

    • Acute rejection
    • Graft survival
    • Mycophenolate mofetil
    • Renal function
    • Renal transplantation
    • Sirolimus

    ASJC Scopus subject areas

    • Immunology and Allergy
    • Transplantation
    • Pharmacology (medical)

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