Single-walled carbon nanotube-based near-infrared optical glucose sensors toward in vivo continuous glucose monitoring

Kyungsuk Yum, Thomas P. McNicholas, Bin Mu, Michael S. Strano

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

This article reviews research efforts on developing single-walled carbon nanotube (SWNT)-based near-infrared (NIR) optical glucose sensors toward long-term in vivo continuous glucose monitoring (CGM). We first discuss the unique optical properties of SWNTs and compare SWNTs with traditional organic and nanoparticle fluorophores regarding in vivo glucose-sensing applications. We then present our development of SWNT-based glucose sensors that use glucose-binding proteins and boronic acids as a high-afinity molecular receptor for glucose and transduce binding events on the receptors to modulate SWNT fluorescence. Finally, we discuss opportunities and challenges in translating the emerging technology of SWNT-based NIR optical glucose sensors into in vivo CGM for practical clinical use.

Original languageEnglish (US)
Pages (from-to)72-87
Number of pages16
JournalJournal of diabetes science and technology
Volume7
Issue number1
DOIs
StatePublished - 2013
Externally publishedYes

Fingerprint

Glucose sensors
Carbon Nanotubes
Optical sensors
Single-walled carbon nanotubes (SWCN)
Glucose
Infrared radiation
Monitoring
Boronic Acids
Fluorophores
Carrier Proteins
Optical properties
Fluorescence
Nanoparticles
Acids
Technology
Research

Keywords

  • Continuous glucose monitoring
  • Glucose
  • Near-infrared fluorescence
  • Single-walled carbon nanotube

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Internal Medicine
  • Bioengineering
  • Biomedical Engineering

Cite this

Single-walled carbon nanotube-based near-infrared optical glucose sensors toward in vivo continuous glucose monitoring. / Yum, Kyungsuk; McNicholas, Thomas P.; Mu, Bin; Strano, Michael S.

In: Journal of diabetes science and technology, Vol. 7, No. 1, 2013, p. 72-87.

Research output: Contribution to journalArticle

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