Single-walled carbon nanotube-based near-infrared optical glucose sensors toward in vivo continuous glucose monitoring

Kyungsuk Yum, Thomas P. McNicholas, Bin Mu, Michael S. Strano

Research output: Contribution to journalArticle

28 Scopus citations

Abstract

This article reviews research efforts on developing single-walled carbon nanotube (SWNT)-based near-infrared (NIR) optical glucose sensors toward long-term in vivo continuous glucose monitoring (CGM). We first discuss the unique optical properties of SWNTs and compare SWNTs with traditional organic and nanoparticle fluorophores regarding in vivo glucose-sensing applications. We then present our development of SWNT-based glucose sensors that use glucose-binding proteins and boronic acids as a high-afinity molecular receptor for glucose and transduce binding events on the receptors to modulate SWNT fluorescence. Finally, we discuss opportunities and challenges in translating the emerging technology of SWNT-based NIR optical glucose sensors into in vivo CGM for practical clinical use.

Original languageEnglish (US)
Pages (from-to)72-87
Number of pages16
JournalJournal of Diabetes Science and Technology
Volume7
Issue number1
DOIs
StatePublished - Jan 2013
Externally publishedYes

Keywords

  • Continuous glucose monitoring
  • Glucose
  • Near-infrared fluorescence
  • Single-walled carbon nanotube

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Bioengineering
  • Biomedical Engineering

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