Single particle imaging with soft x-rays at the linac coherent light source

Andrew V. Martin, Jakob Andreasson, Andrew Aquila, Saša Bajt, Thomas R.M. Barends, Miriam Barthelmess, Anton Barty, W. Henry Benner, Christoph Bostedt, John D. Bozek, Phillip Bucksbaum, Carl Caleman, Nicola Coppola, Daniel P. DePonte, Tomas Ekeberg, Sascha W. Epp, Benjamin Erk, George R. Farquar, Holger Fleckenstein, Lutz Foucar & 51 others Matthias Frank, Lars Gumprecht, Christina Y. Hampton, Max Hantke, Andreas Hartmann, Elisabeth Hartmann, Robert Hartmann, Stephan P. Hau-Riege, Günther Hauser, Peter Holl, André Hoemke, Olof Jönsson, Stephan Kassemeyer, Nils Kimmel, Maya Kiskinova, Faton Krasniqi, Jacek Krzywinski, Mengning Liang, Ne Te Duane Loh, Lukas Lomb, Filipe R.N.C. Maia, Stefano Marchesini, Marc Messerschmidt, Karol Nass, Dučko Odíc, Emanuele Pedersoli, Christian Reich, Daniel Rolles, Benedikt Rudek, Artem Rudenko, Carlo Schmidt, Joachim Schultz, M. Marvin Seibert, Robert L. Shoeman, Raymond G. Sierra, Heike Soltau, Dmitri Starodub, Jan Steinbrener, Francesco Stellato, Lothar Strüder, Martin Svenda, Herbert Tobias, Joachim Ullrich, Georg Weidenspointner, Daniel Westphal, Thomas A. White, Garth Williams, Janos Hajdu, Ilme Schlichting, Michael J. Bogan, Henry N. Chapman

Research output: Chapter in Book/Report/Conference proceedingConference contribution

12 Citations (Scopus)

Abstract

Results of coherent diffractive imaging experiments performed with soft X-rays (1-2 keV) at the Linac Coherent Light Source are presented. Both organic and inorganic nano-sized objects were injected into the XFEL beam as an aerosol focused with an aerodynamic lens. The high intensity and femtosecond duration of X-ray pulses produced by the Linac Coherent Light Source allow structural information to be recorded by X-ray diffraction before the particle is destroyed. Images were formed by using iterative methods to phase single shot diffraction patterns. Strategies for improving the reconstruction methods have been developed. This technique opens up exciting opportunities for biological imaging, allowing structure determination without freezing, staining or crystallization.

Original languageEnglish (US)
Title of host publicationAdvances in X-Ray Free-Electron Lasers
Subtitle of host publicationRadiation Schemes, X-Ray Optics, and Instrumentation
Volume8078
DOIs
StatePublished - Jun 14 2011
Externally publishedYes
EventAdvances in X-Ray Free-Electron Lasers: Radiation Schemes, X-Ray Optics, and Instrumentation - Prague, Czech Republic
Duration: Apr 20 2011Apr 21 2011

Other

OtherAdvances in X-Ray Free-Electron Lasers: Radiation Schemes, X-Ray Optics, and Instrumentation
CountryCzech Republic
CityPrague
Period4/20/114/21/11

Fingerprint

Soft X-ray
coherent light
Light sources
light sources
Imaging
Imaging techniques
X rays
Crystallization
Iterative methods
Aerosols
Freezing
Diffraction patterns
Laser pulses
Lenses
Aerodynamics
x rays
Femtosecond
staining
Aerosol
X-ray Diffraction

Keywords

  • Coherent diffractive imaging
  • LCLS
  • mimivirus

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering

Cite this

Martin, A. V., Andreasson, J., Aquila, A., Bajt, S., Barends, T. R. M., Barthelmess, M., ... Chapman, H. N. (2011). Single particle imaging with soft x-rays at the linac coherent light source. In Advances in X-Ray Free-Electron Lasers: Radiation Schemes, X-Ray Optics, and Instrumentation (Vol. 8078). [807809] https://doi.org/10.1117/12.886754

Single particle imaging with soft x-rays at the linac coherent light source. / Martin, Andrew V.; Andreasson, Jakob; Aquila, Andrew; Bajt, Saša; Barends, Thomas R.M.; Barthelmess, Miriam; Barty, Anton; Benner, W. Henry; Bostedt, Christoph; Bozek, John D.; Bucksbaum, Phillip; Caleman, Carl; Coppola, Nicola; DePonte, Daniel P.; Ekeberg, Tomas; Epp, Sascha W.; Erk, Benjamin; Farquar, George R.; Fleckenstein, Holger; Foucar, Lutz; Frank, Matthias; Gumprecht, Lars; Hampton, Christina Y.; Hantke, Max; Hartmann, Andreas; Hartmann, Elisabeth; Hartmann, Robert; Hau-Riege, Stephan P.; Hauser, Günther; Holl, Peter; Hoemke, André; Jönsson, Olof; Kassemeyer, Stephan; Kimmel, Nils; Kiskinova, Maya; Krasniqi, Faton; Krzywinski, Jacek; Liang, Mengning; Loh, Ne Te Duane; Lomb, Lukas; Maia, Filipe R.N.C.; Marchesini, Stefano; Messerschmidt, Marc; Nass, Karol; Odíc, Dučko; Pedersoli, Emanuele; Reich, Christian; Rolles, Daniel; Rudek, Benedikt; Rudenko, Artem; Schmidt, Carlo; Schultz, Joachim; Seibert, M. Marvin; Shoeman, Robert L.; Sierra, Raymond G.; Soltau, Heike; Starodub, Dmitri; Steinbrener, Jan; Stellato, Francesco; Strüder, Lothar; Svenda, Martin; Tobias, Herbert; Ullrich, Joachim; Weidenspointner, Georg; Westphal, Daniel; White, Thomas A.; Williams, Garth; Hajdu, Janos; Schlichting, Ilme; Bogan, Michael J.; Chapman, Henry N.

Advances in X-Ray Free-Electron Lasers: Radiation Schemes, X-Ray Optics, and Instrumentation. Vol. 8078 2011. 807809.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Martin, AV, Andreasson, J, Aquila, A, Bajt, S, Barends, TRM, Barthelmess, M, Barty, A, Benner, WH, Bostedt, C, Bozek, JD, Bucksbaum, P, Caleman, C, Coppola, N, DePonte, DP, Ekeberg, T, Epp, SW, Erk, B, Farquar, GR, Fleckenstein, H, Foucar, L, Frank, M, Gumprecht, L, Hampton, CY, Hantke, M, Hartmann, A, Hartmann, E, Hartmann, R, Hau-Riege, SP, Hauser, G, Holl, P, Hoemke, A, Jönsson, O, Kassemeyer, S, Kimmel, N, Kiskinova, M, Krasniqi, F, Krzywinski, J, Liang, M, Loh, NTD, Lomb, L, Maia, FRNC, Marchesini, S, Messerschmidt, M, Nass, K, Odíc, D, Pedersoli, E, Reich, C, Rolles, D, Rudek, B, Rudenko, A, Schmidt, C, Schultz, J, Seibert, MM, Shoeman, RL, Sierra, RG, Soltau, H, Starodub, D, Steinbrener, J, Stellato, F, Strüder, L, Svenda, M, Tobias, H, Ullrich, J, Weidenspointner, G, Westphal, D, White, TA, Williams, G, Hajdu, J, Schlichting, I, Bogan, MJ & Chapman, HN 2011, Single particle imaging with soft x-rays at the linac coherent light source. in Advances in X-Ray Free-Electron Lasers: Radiation Schemes, X-Ray Optics, and Instrumentation. vol. 8078, 807809, Advances in X-Ray Free-Electron Lasers: Radiation Schemes, X-Ray Optics, and Instrumentation, Prague, Czech Republic, 4/20/11. https://doi.org/10.1117/12.886754
Martin AV, Andreasson J, Aquila A, Bajt S, Barends TRM, Barthelmess M et al. Single particle imaging with soft x-rays at the linac coherent light source. In Advances in X-Ray Free-Electron Lasers: Radiation Schemes, X-Ray Optics, and Instrumentation. Vol. 8078. 2011. 807809 https://doi.org/10.1117/12.886754
Martin, Andrew V. ; Andreasson, Jakob ; Aquila, Andrew ; Bajt, Saša ; Barends, Thomas R.M. ; Barthelmess, Miriam ; Barty, Anton ; Benner, W. Henry ; Bostedt, Christoph ; Bozek, John D. ; Bucksbaum, Phillip ; Caleman, Carl ; Coppola, Nicola ; DePonte, Daniel P. ; Ekeberg, Tomas ; Epp, Sascha W. ; Erk, Benjamin ; Farquar, George R. ; Fleckenstein, Holger ; Foucar, Lutz ; Frank, Matthias ; Gumprecht, Lars ; Hampton, Christina Y. ; Hantke, Max ; Hartmann, Andreas ; Hartmann, Elisabeth ; Hartmann, Robert ; Hau-Riege, Stephan P. ; Hauser, Günther ; Holl, Peter ; Hoemke, André ; Jönsson, Olof ; Kassemeyer, Stephan ; Kimmel, Nils ; Kiskinova, Maya ; Krasniqi, Faton ; Krzywinski, Jacek ; Liang, Mengning ; Loh, Ne Te Duane ; Lomb, Lukas ; Maia, Filipe R.N.C. ; Marchesini, Stefano ; Messerschmidt, Marc ; Nass, Karol ; Odíc, Dučko ; Pedersoli, Emanuele ; Reich, Christian ; Rolles, Daniel ; Rudek, Benedikt ; Rudenko, Artem ; Schmidt, Carlo ; Schultz, Joachim ; Seibert, M. Marvin ; Shoeman, Robert L. ; Sierra, Raymond G. ; Soltau, Heike ; Starodub, Dmitri ; Steinbrener, Jan ; Stellato, Francesco ; Strüder, Lothar ; Svenda, Martin ; Tobias, Herbert ; Ullrich, Joachim ; Weidenspointner, Georg ; Westphal, Daniel ; White, Thomas A. ; Williams, Garth ; Hajdu, Janos ; Schlichting, Ilme ; Bogan, Michael J. ; Chapman, Henry N. / Single particle imaging with soft x-rays at the linac coherent light source. Advances in X-Ray Free-Electron Lasers: Radiation Schemes, X-Ray Optics, and Instrumentation. Vol. 8078 2011.
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