Single particle imaging with soft x-rays at the linac coherent light source

Andrew V. Martin; Jakob Andreasson; Andrew Aquila; Saša Bajt; Thomas R.M. Barends; Miriam Barthelmess; Anton Barty; W. Henry Benner; Christoph Bostedt; John D. Bozek; Phillip Bucksbaum; Carl Caleman; Nicola Coppola; Daniel P. DePonte; Tomas Ekeberg; Sascha W. Epp; Benjamin Erk; George R. Farquar; Holger Fleckenstein; Lutz Foucar; Matthias Frank; Lars Gumprecht; Christina Y. Hampton; Max Hantke; Andreas Hartmann; Elisabeth Hartmann; Robert Hartmann; Stephan P. Hau-Riege; Günther Hauser; Peter Holl; André Hoemke; Olof Jönsson; Stephan Kassemeyer; Nils Kimmel; Maya Kiskinova; Faton Krasniqi; Jacek Krzywinski; Mengning Liang; Ne Te Duane Loh; Lukas Lomb; Filipe R.N.C. Maia; Stefano Marchesini; Marc Messerschmidt; Karol Nass; Dučko Odíc; Emanuele Pedersoli; Christian Reich; Daniel Rolles; Benedikt Rudek; Artem Rudenko; Carlo Schmidt; Joachim Schultz; M. Marvin Seibert; Robert L. Shoeman; Raymond G. Sierra; Heike Soltau; Dmitri Starodub; Jan Steinbrener; Francesco Stellato; Lothar Strüder; Martin Svenda; Herbert Tobias; Joachim Ullrich; Georg Weidenspointner; Daniel Westphal; Thomas A. White; Garth Williams; Janos Hajdu; Ilme Schlichting; Michael J. Bogan; Henry N. Chapman

doi:10.1117/12.886754

Single particle imaging with soft x-rays at the linac coherent light source

Andrew V. Martin, Jakob Andreasson, Andrew Aquila, Saša Bajt, Thomas R.M. Barends, Miriam Barthelmess, Anton Barty, W. Henry Benner, Christoph Bostedt, John D. Bozek, Phillip Bucksbaum, Carl Caleman, Nicola Coppola, Daniel P. DePonte, Tomas Ekeberg, Sascha W. Epp, Benjamin Erk, George R. Farquar, Holger Fleckenstein, Lutz FoucarMatthias Frank, Lars Gumprecht, Christina Y. Hampton, Max Hantke, Andreas Hartmann, Elisabeth Hartmann, Robert Hartmann, Stephan P. Hau-Riege, Günther Hauser, Peter Holl, André Hoemke, Olof Jönsson, Stephan Kassemeyer, Nils Kimmel, Maya Kiskinova, Faton Krasniqi, Jacek Krzywinski, Mengning Liang, Ne Te Duane Loh, Lukas Lomb, Filipe R.N.C. Maia, Stefano Marchesini, Marc Messerschmidt, Karol Nass, Dučko Odíc, Emanuele Pedersoli, Christian Reich, Daniel Rolles, Benedikt Rudek, Artem Rudenko, Carlo Schmidt, Joachim Schultz, M. Marvin Seibert, Robert L. Shoeman, Raymond G. Sierra, Heike Soltau, Dmitri Starodub, Jan Steinbrener, Francesco Stellato, Lothar Strüder, Martin Svenda, Herbert Tobias, Joachim Ullrich, Georg Weidenspointner, Daniel Westphal, Thomas A. White, Garth Williams, Janos Hajdu, Ilme Schlichting, Michael J. Bogan, Henry N. Chapman

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

13 Scopus citations

Abstract

Results of coherent diffractive imaging experiments performed with soft X-rays (1-2 keV) at the Linac Coherent Light Source are presented. Both organic and inorganic nano-sized objects were injected into the XFEL beam as an aerosol focused with an aerodynamic lens. The high intensity and femtosecond duration of X-ray pulses produced by the Linac Coherent Light Source allow structural information to be recorded by X-ray diffraction before the particle is destroyed. Images were formed by using iterative methods to phase single shot diffraction patterns. Strategies for improving the reconstruction methods have been developed. This technique opens up exciting opportunities for biological imaging, allowing structure determination without freezing, staining or crystallization.

Original language	English (US)
Title of host publication	Advances in X-Ray Free-Electron Lasers
Subtitle of host publication	Radiation Schemes, X-Ray Optics, and Instrumentation
DOIs	https://doi.org/10.1117/12.886754
State	Published - 2011
Externally published	Yes
Event	Advances in X-Ray Free-Electron Lasers: Radiation Schemes, X-Ray Optics, and Instrumentation - Prague, Czech Republic Duration: Apr 20 2011 → Apr 21 2011

Publication series

Name	Proceedings of SPIE - The International Society for Optical Engineering
Volume	8078
ISSN (Print)	0277-786X

Other

Other	Advances in X-Ray Free-Electron Lasers: Radiation Schemes, X-Ray Optics, and Instrumentation
Country/Territory	Czech Republic
City	Prague
Period	4/20/11 → 4/21/11

Keywords

Coherent diffractive imaging
LCLS
mimivirus

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Condensed Matter Physics
Computer Science Applications
Applied Mathematics
Electrical and Electronic Engineering

Access to Document

10.1117/12.886754

Cite this

Martin, A. V., Andreasson, J., Aquila, A., Bajt, S., Barends, T. R. M., Barthelmess, M., Barty, A., Benner, W. H., Bostedt, C., Bozek, J. D., Bucksbaum, P., Caleman, C., Coppola, N., DePonte, D. P., Ekeberg, T., Epp, S. W., Erk, B., Farquar, G. R., Fleckenstein, H., ... Chapman, H. N. (2011). Single particle imaging with soft x-rays at the linac coherent light source. In Advances in X-Ray Free-Electron Lasers: Radiation Schemes, X-Ray Optics, and Instrumentation Article 807809 (Proceedings of SPIE - The International Society for Optical Engineering; Vol. 8078). https://doi.org/10.1117/12.886754

Single particle imaging with soft x-rays at the linac coherent light source. / Martin, Andrew V.; Andreasson, Jakob; Aquila, Andrew et al.
Advances in X-Ray Free-Electron Lasers: Radiation Schemes, X-Ray Optics, and Instrumentation. 2011. 807809 (Proceedings of SPIE - The International Society for Optical Engineering; Vol. 8078).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Martin, AV, Andreasson, J, Aquila, A, Bajt, S, Barends, TRM, Barthelmess, M, Barty, A, Benner, WH, Bostedt, C, Bozek, JD, Bucksbaum, P, Caleman, C, Coppola, N, DePonte, DP, Ekeberg, T, Epp, SW, Erk, B, Farquar, GR, Fleckenstein, H, Foucar, L, Frank, M, Gumprecht, L, Hampton, CY, Hantke, M, Hartmann, A, Hartmann, E, Hartmann, R, Hau-Riege, SP, Hauser, G, Holl, P, Hoemke, A, Jönsson, O, Kassemeyer, S, Kimmel, N, Kiskinova, M, Krasniqi, F, Krzywinski, J, Liang, M, Loh, NTD, Lomb, L, Maia, FRNC, Marchesini, S, Messerschmidt, M, Nass, K, Odíc, D, Pedersoli, E, Reich, C, Rolles, D, Rudek, B, Rudenko, A, Schmidt, C, Schultz, J, Seibert, MM, Shoeman, RL, Sierra, RG, Soltau, H, Starodub, D, Steinbrener, J, Stellato, F, Strüder, L, Svenda, M, Tobias, H, Ullrich, J, Weidenspointner, G, Westphal, D, White, TA, Williams, G, Hajdu, J, Schlichting, I, Bogan, MJ & Chapman, HN 2011, Single particle imaging with soft x-rays at the linac coherent light source. in Advances in X-Ray Free-Electron Lasers: Radiation Schemes, X-Ray Optics, and Instrumentation., 807809, Proceedings of SPIE - The International Society for Optical Engineering, vol. 8078, Advances in X-Ray Free-Electron Lasers: Radiation Schemes, X-Ray Optics, and Instrumentation, Prague, Czech Republic, 4/20/11. https://doi.org/10.1117/12.886754

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title = "Single particle imaging with soft x-rays at the linac coherent light source",

abstract = "Results of coherent diffractive imaging experiments performed with soft X-rays (1-2 keV) at the Linac Coherent Light Source are presented. Both organic and inorganic nano-sized objects were injected into the XFEL beam as an aerosol focused with an aerodynamic lens. The high intensity and femtosecond duration of X-ray pulses produced by the Linac Coherent Light Source allow structural information to be recorded by X-ray diffraction before the particle is destroyed. Images were formed by using iterative methods to phase single shot diffraction patterns. Strategies for improving the reconstruction methods have been developed. This technique opens up exciting opportunities for biological imaging, allowing structure determination without freezing, staining or crystallization.",

keywords = "Coherent diffractive imaging, LCLS, mimivirus",

author = "Martin, {Andrew V.} and Jakob Andreasson and Andrew Aquila and Sa{\v s}a Bajt and Barends, {Thomas R.M.} and Miriam Barthelmess and Anton Barty and Benner, {W. Henry} and Christoph Bostedt and Bozek, {John D.} and Phillip Bucksbaum and Carl Caleman and Nicola Coppola and DePonte, {Daniel P.} and Tomas Ekeberg and Epp, {Sascha W.} and Benjamin Erk and Farquar, {George R.} and Holger Fleckenstein and Lutz Foucar and Matthias Frank and Lars Gumprecht and Hampton, {Christina Y.} and Max Hantke and Andreas Hartmann and Elisabeth Hartmann and Robert Hartmann and Hau-Riege, {Stephan P.} and G{\"u}nther Hauser and Peter Holl and Andr{\'e} Hoemke and Olof J{\"o}nsson and Stephan Kassemeyer and Nils Kimmel and Maya Kiskinova and Faton Krasniqi and Jacek Krzywinski and Mengning Liang and Loh, {Ne Te Duane} and Lukas Lomb and Maia, {Filipe R.N.C.} and Stefano Marchesini and Marc Messerschmidt and Karol Nass and Du{\v c}ko Od{\'i}c and Emanuele Pedersoli and Christian Reich and Daniel Rolles and Benedikt Rudek and Artem Rudenko and Carlo Schmidt and Joachim Schultz and Seibert, {M. Marvin} and Shoeman, {Robert L.} and Sierra, {Raymond G.} and Heike Soltau and Dmitri Starodub and Jan Steinbrener and Francesco Stellato and Lothar Str{\"u}der and Martin Svenda and Herbert Tobias and Joachim Ullrich and Georg Weidenspointner and Daniel Westphal and White, {Thomas A.} and Garth Williams and Janos Hajdu and Ilme Schlichting and Bogan, {Michael J.} and Chapman, {Henry N.}",

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doi = "10.1117/12.886754",

language = "English (US)",

isbn = "9780819486684",

series = "Proceedings of SPIE - The International Society for Optical Engineering",

booktitle = "Advances in X-Ray Free-Electron Lasers",

note = "Advances in X-Ray Free-Electron Lasers: Radiation Schemes, X-Ray Optics, and Instrumentation ; Conference date: 20-04-2011 Through 21-04-2011",

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T1 - Single particle imaging with soft x-rays at the linac coherent light source

AU - Martin, Andrew V.

AU - Andreasson, Jakob

AU - Aquila, Andrew

AU - Bajt, Saša

AU - Barends, Thomas R.M.

AU - Barthelmess, Miriam

AU - Barty, Anton

AU - Benner, W. Henry

AU - Bostedt, Christoph

AU - Bozek, John D.

AU - Bucksbaum, Phillip

AU - Caleman, Carl

AU - Coppola, Nicola

AU - DePonte, Daniel P.

AU - Ekeberg, Tomas

AU - Epp, Sascha W.

AU - Erk, Benjamin

AU - Farquar, George R.

AU - Fleckenstein, Holger

AU - Foucar, Lutz

AU - Frank, Matthias

AU - Gumprecht, Lars

AU - Hampton, Christina Y.

AU - Hantke, Max

AU - Hartmann, Andreas

AU - Hartmann, Elisabeth

AU - Hartmann, Robert

AU - Hau-Riege, Stephan P.

AU - Hauser, Günther

AU - Holl, Peter

AU - Hoemke, André

AU - Jönsson, Olof

AU - Kassemeyer, Stephan

AU - Kimmel, Nils

AU - Kiskinova, Maya

AU - Krasniqi, Faton

AU - Krzywinski, Jacek

AU - Liang, Mengning

AU - Loh, Ne Te Duane

AU - Lomb, Lukas

AU - Maia, Filipe R.N.C.

AU - Marchesini, Stefano

AU - Messerschmidt, Marc

AU - Nass, Karol

AU - Odíc, Dučko

AU - Pedersoli, Emanuele

AU - Reich, Christian

AU - Rolles, Daniel

AU - Rudek, Benedikt

AU - Rudenko, Artem

AU - Schmidt, Carlo

AU - Schultz, Joachim

AU - Seibert, M. Marvin

AU - Shoeman, Robert L.

AU - Sierra, Raymond G.

AU - Soltau, Heike

AU - Starodub, Dmitri

AU - Steinbrener, Jan

AU - Stellato, Francesco

AU - Strüder, Lothar

AU - Svenda, Martin

AU - Tobias, Herbert

AU - Ullrich, Joachim

AU - Weidenspointner, Georg

AU - Westphal, Daniel

AU - White, Thomas A.

AU - Williams, Garth

AU - Hajdu, Janos

AU - Schlichting, Ilme

AU - Bogan, Michael J.

AU - Chapman, Henry N.

PY - 2011

Y1 - 2011

N2 - Results of coherent diffractive imaging experiments performed with soft X-rays (1-2 keV) at the Linac Coherent Light Source are presented. Both organic and inorganic nano-sized objects were injected into the XFEL beam as an aerosol focused with an aerodynamic lens. The high intensity and femtosecond duration of X-ray pulses produced by the Linac Coherent Light Source allow structural information to be recorded by X-ray diffraction before the particle is destroyed. Images were formed by using iterative methods to phase single shot diffraction patterns. Strategies for improving the reconstruction methods have been developed. This technique opens up exciting opportunities for biological imaging, allowing structure determination without freezing, staining or crystallization.

AB - Results of coherent diffractive imaging experiments performed with soft X-rays (1-2 keV) at the Linac Coherent Light Source are presented. Both organic and inorganic nano-sized objects were injected into the XFEL beam as an aerosol focused with an aerodynamic lens. The high intensity and femtosecond duration of X-ray pulses produced by the Linac Coherent Light Source allow structural information to be recorded by X-ray diffraction before the particle is destroyed. Images were formed by using iterative methods to phase single shot diffraction patterns. Strategies for improving the reconstruction methods have been developed. This technique opens up exciting opportunities for biological imaging, allowing structure determination without freezing, staining or crystallization.

KW - Coherent diffractive imaging

KW - LCLS

KW - mimivirus

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DO - 10.1117/12.886754

M3 - Conference contribution

AN - SCOPUS:79958232047

SN - 9780819486684

T3 - Proceedings of SPIE - The International Society for Optical Engineering

BT - Advances in X-Ray Free-Electron Lasers

T2 - Advances in X-Ray Free-Electron Lasers: Radiation Schemes, X-Ray Optics, and Instrumentation

Y2 - 20 April 2011 through 21 April 2011

ER -

Single particle imaging with soft x-rays at the linac coherent light source

Abstract

Publication series

Other

Keywords

ASJC Scopus subject areas

Access to Document

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