Single particle imaging with soft x-rays at the linac coherent light source

Andrew V. Martin, Jakob Andreasson, Andrew Aquila, Saša Bajt, Thomas R.M. Barends, Miriam Barthelmess, Anton Barty, W. Henry Benner, Christoph Bostedt, John D. Bozek, Phillip Bucksbaum, Carl Caleman, Nicola Coppola, Daniel P. DePonte, Tomas Ekeberg, Sascha W. Epp, Benjamin Erk, George R. Farquar, Holger Fleckenstein, Lutz FoucarMatthias Frank, Lars Gumprecht, Christina Y. Hampton, Max Hantke, Andreas Hartmann, Elisabeth Hartmann, Robert Hartmann, Stephan P. Hau-Riege, Günther Hauser, Peter Holl, André Hoemke, Olof Jönsson, Stephan Kassemeyer, Nils Kimmel, Maya Kiskinova, Faton Krasniqi, Jacek Krzywinski, Mengning Liang, Ne Te Duane Loh, Lukas Lomb, Filipe R.N.C. Maia, Stefano Marchesini, Marc Messerschmidt, Karol Nass, Dučko Odíc, Emanuele Pedersoli, Christian Reich, Daniel Rolles, Benedikt Rudek, Artem Rudenko, Carlo Schmidt, Joachim Schultz, M. Marvin Seibert, Robert L. Shoeman, Raymond G. Sierra, Heike Soltau, Dmitri Starodub, Jan Steinbrener, Francesco Stellato, Lothar Strüder, Martin Svenda, Herbert Tobias, Joachim Ullrich, Georg Weidenspointner, Daniel Westphal, Thomas A. White, Garth Williams, Janos Hajdu, Ilme Schlichting, Michael J. Bogan, Henry N. Chapman

Research output: Chapter in Book/Report/Conference proceedingConference contribution

13 Scopus citations


Results of coherent diffractive imaging experiments performed with soft X-rays (1-2 keV) at the Linac Coherent Light Source are presented. Both organic and inorganic nano-sized objects were injected into the XFEL beam as an aerosol focused with an aerodynamic lens. The high intensity and femtosecond duration of X-ray pulses produced by the Linac Coherent Light Source allow structural information to be recorded by X-ray diffraction before the particle is destroyed. Images were formed by using iterative methods to phase single shot diffraction patterns. Strategies for improving the reconstruction methods have been developed. This technique opens up exciting opportunities for biological imaging, allowing structure determination without freezing, staining or crystallization.

Original languageEnglish (US)
Title of host publicationAdvances in X-Ray Free-Electron Lasers
Subtitle of host publicationRadiation Schemes, X-Ray Optics, and Instrumentation
StatePublished - 2011
Externally publishedYes
EventAdvances in X-Ray Free-Electron Lasers: Radiation Schemes, X-Ray Optics, and Instrumentation - Prague, Czech Republic
Duration: Apr 20 2011Apr 21 2011

Publication series

NameProceedings of SPIE - The International Society for Optical Engineering
ISSN (Print)0277-786X


OtherAdvances in X-Ray Free-Electron Lasers: Radiation Schemes, X-Ray Optics, and Instrumentation
Country/TerritoryCzech Republic


  • Coherent diffractive imaging
  • LCLS
  • mimivirus

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering


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