TY - JOUR
T1 - Single-nucleotide polymorphisms are associated with cognitive decline at Alzheimer's disease conversion within mild cognitive impairment patients
AU - for the
AU - Alzheimer's Disease Neuroimaging Initiative
AU - Lee, Eunjee
AU - Giovanello, Kelly S.
AU - Saykin, Andrew J.
AU - Xie, Fengchang
AU - Kong, Dehan
AU - Wang, Yue
AU - Yang, Liuqing
AU - Ibrahim, Joseph G.
AU - Doraiswamy, P. Murali
AU - Zhu, Hongtu
N1 - Funding Information:
This work was supported in part by National Institutes of Health (NIH) grants MH086633, National Science Foundation (NSF) grants SES-1357666 and DMS-1407655, and a grant from Cancer Prevention Research Institute of Texas to H.Z. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH and NSF. Data used in preparation of this article were obtained from the Alzheimer's Disease Neuroimaging Initiative (ADNI) database (adni.loni.usc.edu). As such, the investigators within the ADNI contributed to the design and implementation of ADNI and/or provided data but did not participate in analysis or writing of this report. A complete listing of ADNI investigators can be found at http://adni.loni.usc.edu/wpcontent/uploads/how_to_apply/ADNI_Acknowledgement_List.pdf.
Publisher Copyright:
© 2017 The Authors
PY - 2017
Y1 - 2017
N2 - Introduction The growing public threat of Alzheimer's disease (AD) has raised the urgency to quantify the degree of cognitive decline during the conversion process of mild cognitive impairment (MCI) to AD and its underlying genetic pathway. The aim of this article was to test genetic common variants associated with accelerated cognitive decline after the conversion of MCI to AD. Methods In 583 subjects with MCI enrolled in the Alzheimer's Disease Neuroimaging Initiative (ADNI; ADNI-1, ADNI-Go, and ADNI-2), 245 MCI participants converted to AD at follow-up. We tested the interaction effects between individual single-nucleotide polymorphisms and AD diagnosis trajectory on the longitudinal Alzheimer's Disease Assessment Scale-Cognition scores. Results Our findings reveal six genes, including BDH1, ST6GAL1, RAB20, PDS5B, ADARB2, and SPSB1, which are directly or indirectly related to MCI conversion to AD. Discussion This genome-wide association study sheds light on a genetic mechanism of longitudinal cognitive changes during the transition period from MCI to AD.
AB - Introduction The growing public threat of Alzheimer's disease (AD) has raised the urgency to quantify the degree of cognitive decline during the conversion process of mild cognitive impairment (MCI) to AD and its underlying genetic pathway. The aim of this article was to test genetic common variants associated with accelerated cognitive decline after the conversion of MCI to AD. Methods In 583 subjects with MCI enrolled in the Alzheimer's Disease Neuroimaging Initiative (ADNI; ADNI-1, ADNI-Go, and ADNI-2), 245 MCI participants converted to AD at follow-up. We tested the interaction effects between individual single-nucleotide polymorphisms and AD diagnosis trajectory on the longitudinal Alzheimer's Disease Assessment Scale-Cognition scores. Results Our findings reveal six genes, including BDH1, ST6GAL1, RAB20, PDS5B, ADARB2, and SPSB1, which are directly or indirectly related to MCI conversion to AD. Discussion This genome-wide association study sheds light on a genetic mechanism of longitudinal cognitive changes during the transition period from MCI to AD.
KW - Alzheimer's disease
KW - Cognitive decline
KW - GWAS
KW - Longitudinal study
KW - Mild cognitive impairment
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U2 - 10.1016/j.dadm.2017.04.004
DO - 10.1016/j.dadm.2017.04.004
M3 - Article
AN - SCOPUS:85019626715
SN - 2352-8729
VL - 8
SP - 86
EP - 95
JO - Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
JF - Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
ER -