Simulation of the ephaptic effect in the cone-horizontal cell synapse of the retina

Carl Gardner, Jeremiah R. Jones, Steven Baer, Shaojie Chang

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

The drift-diffusion (Poisson-Nernst-Planck) model-including a numerical model for cell membranes that resolves surface-charge boundary layers-is applied to the cone-horizontal cell synapse in the outer plexiform layer of the retina. Numerical simulations reproduce the experimental calcium current-voltage (IV) curves for the goldfish retina in response to a bright spot, with and without an illuminated background. The ephaptic (electrical) effect is demonstrated by computing the shift in the IV curve for background off versus background on for increasingly narrower openings between the sides of the cone and the horizontal cell.

Original languageEnglish (US)
Pages (from-to)636-648
Number of pages13
JournalSIAM Journal on Applied Mathematics
Volume73
Issue number2
DOIs
StatePublished - May 28 2013

Keywords

  • Drift-diffusion model
  • Ephaptic effect
  • Retina
  • Synapse

ASJC Scopus subject areas

  • Applied Mathematics

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