Simulation-directed amplifiable nanoparticle enhanced quantitative scattering assay under low magnification dark field microscopy

Dali Sun, Li Yang, Christopher J. Lyon, Tony Hu

Research output: Contribution to journalArticle

Abstract

Nanoparticle-enhanced assays read by high-magnification dark-field microscopy require time-intensive analysis methods subject to selection bias, which can be resolved by using low magnification dark-field assays (LMDFA), at the cost of reduced sensitivity. We have simulated and experimentally validated a tunable linker-based signal amplification strategy yielding 6-fold enhanced LMDFA sensitivity.

Original languageEnglish (US)
Pages (from-to)5416-5419
Number of pages4
JournalJournal of Materials Chemistry B
Volume8
Issue number25
DOIs
StatePublished - Jul 7 2020

ASJC Scopus subject areas

  • Chemistry(all)
  • Biomedical Engineering
  • Materials Science(all)

Fingerprint Dive into the research topics of 'Simulation-directed amplifiable nanoparticle enhanced quantitative scattering assay under low magnification dark field microscopy'. Together they form a unique fingerprint.

  • Cite this