Abstract

Capillary electrophoresis and similar techniques which use an electrified contracting-flow interface (gradient elution moving boundary electrophoresis, electrophoretic exclusion, for examples) are widely used, but the detailed flow dynamics and local electric field effects within this zone have only recently been quantitatively investigated. The motivating force behind this work is establishing particle flow based visualization tools enabling advances for arbitrary interfacial designs beyond this traditional flow/electric field interface. These tools work with pre-computed 2-dimensional fundamental interacting fields which govern particle and(or) fluid flow and can now be obtained from various computational fluid dynamics (CFD) software packages. The particle-flow visualization calculations implemented in the tool and are built upon a solid foundation in fluid dynamics. The module developed in here provides a simulated video particle observation tool which generates a fast check for legitimacy. Further, estimating the accuracy and precision of full 2-D and 3-D simulation is notoriously difficult and a centerline estimation is used to quickly and easily quantitate behaviors in support of decision points. This tool and the recent quantitative assessment of particle behavior within the interfacial area have set the stage for new designs which can emphasize advantageous behaviors not offered by the traditional configuration.

Original languageEnglish (US)
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
Volume9017
DOIs
StatePublished - 2014
Event21st annual IS and T/SPIE Conference on Visualization and Analysis, VDA 2014 - San Francisco, CA, United States
Duration: Feb 3 2014Feb 5 2014

Other

Other21st annual IS and T/SPIE Conference on Visualization and Analysis, VDA 2014
CountryUnited States
CitySan Francisco, CA
Period2/3/142/5/14

Fingerprint

electrokinetics
Velocity Field
Visualization
velocity distribution
electrophoresis
Simulation
Electrophoresis
simulation
Electric Field
Electric field effects
Flow Visualization
Capillary electrophoresis
elution
electric fields
Moving Boundary
flow visualization
Flow visualization
fluid dynamics
Local Field
Fluid Dynamics

Keywords

  • Electrophoretic capture
  • Particle Flow Visualization
  • Simulation

ASJC Scopus subject areas

  • Applied Mathematics
  • Computer Science Applications
  • Electrical and Electronic Engineering
  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics

Cite this

Mahanti, P., Taylor, T., Cochran, D., Keebaugh, M., & Hayes, M. (2014). Simulation and visualization of velocity fields in simple electrokinetic devices. In Proceedings of SPIE - The International Society for Optical Engineering (Vol. 9017). [90170M] https://doi.org/10.1117/12.2042524

Simulation and visualization of velocity fields in simple electrokinetic devices. / Mahanti, Prasun; Taylor, Thomas; Cochran, Douglas; Keebaugh, Michael; Hayes, Mark.

Proceedings of SPIE - The International Society for Optical Engineering. Vol. 9017 2014. 90170M.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Mahanti, P, Taylor, T, Cochran, D, Keebaugh, M & Hayes, M 2014, Simulation and visualization of velocity fields in simple electrokinetic devices. in Proceedings of SPIE - The International Society for Optical Engineering. vol. 9017, 90170M, 21st annual IS and T/SPIE Conference on Visualization and Analysis, VDA 2014, San Francisco, CA, United States, 2/3/14. https://doi.org/10.1117/12.2042524
Mahanti P, Taylor T, Cochran D, Keebaugh M, Hayes M. Simulation and visualization of velocity fields in simple electrokinetic devices. In Proceedings of SPIE - The International Society for Optical Engineering. Vol. 9017. 2014. 90170M https://doi.org/10.1117/12.2042524
Mahanti, Prasun ; Taylor, Thomas ; Cochran, Douglas ; Keebaugh, Michael ; Hayes, Mark. / Simulation and visualization of velocity fields in simple electrokinetic devices. Proceedings of SPIE - The International Society for Optical Engineering. Vol. 9017 2014.
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