Simple multi-scale modeling of the transmission dynamics of the 1905 plague epidemic in Bombay

Bruce Pell, Tin Phan, Erica M. Rutter, Gerardo Chowell, Yang Kuang

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

The first few disease generations of an infectious disease outbreak is the most critical phase to implement control interventions. The lack of accurate data and information during the early transmission phase hinders the application of complex compartmental models to make predictions and forecasts about important epidemic quantities. Thus, simpler models are often times better tools to understand the early dynamics of an outbreak particularly in the context of limited data. In this paper we mechanistically derive and fit a family of logistic models to spatial-temporal data of the 1905 plague epidemic in Bombay, India. We systematically compare parameter estimates, reproduction numbers, model fit, and short-term forecasts across models at different spatial resolutions. At the same time, we also assess the presence of sub-exponential growth dynamics at different spatial scales and investigate the role of spatial structure and data resolution (district level data and city level data) using simple structured models. Our results for the 1905 plague epidemic in Bombay indicates that it is possible for the growth of an epidemic in the early phase to be sub-exponential at sub-city level, while maintaining near exponential growth at an aggregated city level. We also show that the rate of movement between districts can have a significant effect on the final epidemic size.

Original languageEnglish (US)
JournalMathematical Biosciences
DOIs
StateAccepted/In press - Jan 1 2018

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Keywords

  • 1905 Bombay plague
  • Disease transmission dynamics
  • Mathematical modeling
  • Multi-scale modeling
  • Plague epidemic
  • Sub-exponential growth

ASJC Scopus subject areas

  • Statistics and Probability
  • Modeling and Simulation
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Agricultural and Biological Sciences(all)
  • Applied Mathematics

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