Simple evolutionary pathways to complex proteins

Michael Lynch, Michael J. Behe, David W. Snoke

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

A recent paper in this journal has challenged the idea that complex adaptive features of proteins can be explained by known molecular, genetic, and evolutionary mechanisms. It is shown here that the conclusions of this prior work are an artifact of unwarranted biological assumptions, inappropriate mathematical modeling, and faulty logic. Numerous simple pathways exist by which adaptive multi-residue functions can evolve on time scales of a million years (or much less) in populations of only moderate size. Thus, the classical evolutionary trajectory of descent with modification is adequate to explain the diversification of protein functions.

Original languageEnglish (US)
Pages (from-to)2217-2227
Number of pages11
JournalProtein Science
Volume14
Issue number9
DOIs
StatePublished - Sep 1 2005
Externally publishedYes

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Artifacts
Molecular Biology
Proteins
Trajectories
Population

Keywords

  • Evolutionary theory
  • Gene duplication
  • Microevolutionary theory
  • Multi-residue functions
  • Mutation
  • Neofunctionalization
  • Population genetics
  • Protein evolution
  • Random genetic drift

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

Cite this

Simple evolutionary pathways to complex proteins. / Lynch, Michael; Behe, Michael J.; Snoke, David W.

In: Protein Science, Vol. 14, No. 9, 01.09.2005, p. 2217-2227.

Research output: Contribution to journalArticle

Lynch, Michael ; Behe, Michael J. ; Snoke, David W. / Simple evolutionary pathways to complex proteins. In: Protein Science. 2005 ; Vol. 14, No. 9. pp. 2217-2227.
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