Simple convergent-nozzle aerosol injector for single-particle diffractive imaging with X-ray free-electron lasers

Richard Kirian; S. Awel; N. Eckerskorn; H. Fleckenstein; M. Wiedorn; L. Adriano; S. Bajt; M. Barthelmess; R. Bean; K. R. Beyerlein; L. M G Chavas; M. Domaracky; M. Heymann; D. A. Horke; J. Knoska; M. Metz; A. Morgan; D. Oberthuer; N. Roth; T. Sato; P. L. Xavier; O. Yefanov; A. V. Rode; J. Küpper; H. N. Chapman

doi:10.1063/1.4922648

Simple convergent-nozzle aerosol injector for single-particle diffractive imaging with X-ray free-electron lasers

Richard Kirian, S. Awel, N. Eckerskorn, H. Fleckenstein, M. Wiedorn, L. Adriano, S. Bajt, M. Barthelmess, R. Bean, K. R. Beyerlein, L. M G Chavas, M. Domaracky, M. Heymann, D. A. Horke, J. Knoska, M. Metz, A. Morgan, D. Oberthuer, N. Roth, T. SatoP. L. Xavier, O. Yefanov, A. V. Rode, J. Küpper, H. N. Chapman

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26 Scopus citations

Abstract

A major challenge in high-resolution x-ray free-electron laser-based coherent diffractive imaging is the development of aerosol injectors that can efficiently deliver particles to the peak intensity of the focused X-ray beam. Here, we consider the use of a simple convergent-orifice nozzle for producing tightly focused beams of particles. Through optical imaging we show that 0.5 μm particles can be focused to a full-width at half maximum diameter of 4.2 μm, and we demonstrate the use of such a nozzle for injecting viruses into a micro-focused soft-X-ray FEL beam.

Original language	English (US)
Article number	041717
Journal	Structural Dynamics
Volume	2
Issue number	4
DOIs	https://doi.org/10.1063/1.4922648
State	Published - Jul 1 2015

ASJC Scopus subject areas

Radiation
Instrumentation
Condensed Matter Physics
Spectroscopy

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Kirian, R., Awel, S., Eckerskorn, N., Fleckenstein, H., Wiedorn, M., Adriano, L., Bajt, S., Barthelmess, M., Bean, R., Beyerlein, K. R., Chavas, L. M. G., Domaracky, M., Heymann, M., Horke, D. A., Knoska, J., Metz, M., Morgan, A., Oberthuer, D., Roth, N., ... Chapman, H. N. (2015). Simple convergent-nozzle aerosol injector for single-particle diffractive imaging with X-ray free-electron lasers. Structural Dynamics, 2(4), Article 041717. https://doi.org/10.1063/1.4922648

Kirian, R, Awel, S, Eckerskorn, N, Fleckenstein, H, Wiedorn, M, Adriano, L, Bajt, S, Barthelmess, M, Bean, R, Beyerlein, KR, Chavas, LMG, Domaracky, M, Heymann, M, Horke, DA, Knoska, J, Metz, M, Morgan, A, Oberthuer, D, Roth, N, Sato, T, Xavier, PL, Yefanov, O, Rode, AV, Küpper, J & Chapman, HN 2015, 'Simple convergent-nozzle aerosol injector for single-particle diffractive imaging with X-ray free-electron lasers', Structural Dynamics, vol. 2, no. 4, 041717. https://doi.org/10.1063/1.4922648

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title = "Simple convergent-nozzle aerosol injector for single-particle diffractive imaging with X-ray free-electron lasers",

abstract = "A major challenge in high-resolution x-ray free-electron laser-based coherent diffractive imaging is the development of aerosol injectors that can efficiently deliver particles to the peak intensity of the focused X-ray beam. Here, we consider the use of a simple convergent-orifice nozzle for producing tightly focused beams of particles. Through optical imaging we show that 0.5 μm particles can be focused to a full-width at half maximum diameter of 4.2 μm, and we demonstrate the use of such a nozzle for injecting viruses into a micro-focused soft-X-ray FEL beam.",

author = "Richard Kirian and S. Awel and N. Eckerskorn and H. Fleckenstein and M. Wiedorn and L. Adriano and S. Bajt and M. Barthelmess and R. Bean and Beyerlein, {K. R.} and Chavas, {L. M G} and M. Domaracky and M. Heymann and Horke, {D. A.} and J. Knoska and M. Metz and A. Morgan and D. Oberthuer and N. Roth and T. Sato and Xavier, {P. L.} and O. Yefanov and Rode, {A. V.} and J. K{\"u}pper and Chapman, {H. N.}",

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AU - Kirian, Richard

AU - Awel, S.

AU - Eckerskorn, N.

AU - Fleckenstein, H.

AU - Wiedorn, M.

AU - Adriano, L.

AU - Bajt, S.

AU - Barthelmess, M.

AU - Bean, R.

AU - Beyerlein, K. R.

AU - Chavas, L. M G

AU - Domaracky, M.

AU - Heymann, M.

AU - Horke, D. A.

AU - Knoska, J.

AU - Metz, M.

AU - Morgan, A.

AU - Oberthuer, D.

AU - Roth, N.

AU - Sato, T.

AU - Xavier, P. L.

AU - Yefanov, O.

AU - Rode, A. V.

AU - Küpper, J.

AU - Chapman, H. N.

PY - 2015/7/1

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AB - A major challenge in high-resolution x-ray free-electron laser-based coherent diffractive imaging is the development of aerosol injectors that can efficiently deliver particles to the peak intensity of the focused X-ray beam. Here, we consider the use of a simple convergent-orifice nozzle for producing tightly focused beams of particles. Through optical imaging we show that 0.5 μm particles can be focused to a full-width at half maximum diameter of 4.2 μm, and we demonstrate the use of such a nozzle for injecting viruses into a micro-focused soft-X-ray FEL beam.

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Simple convergent-nozzle aerosol injector for single-particle diffractive imaging with X-ray free-electron lasers

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