Simple convergent-nozzle aerosol injector for single-particle diffractive imaging with X-ray free-electron lasers

Richard Kirian, S. Awel, N. Eckerskorn, H. Fleckenstein, M. Wiedorn, L. Adriano, S. Bajt, M. Barthelmess, R. Bean, K. R. Beyerlein, L. M G Chavas, M. Domaracky, M. Heymann, D. A. Horke, J. Knoska, M. Metz, A. Morgan, D. Oberthuer, N. Roth, T. SatoP. L. Xavier, O. Yefanov, A. V. Rode, J. Küpper, H. N. Chapman

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

A major challenge in high-resolution x-ray free-electron laser-based coherent diffractive imaging is the development of aerosol injectors that can efficiently deliver particles to the peak intensity of the focused X-ray beam. Here, we consider the use of a simple convergent-orifice nozzle for producing tightly focused beams of particles. Through optical imaging we show that 0.5 μm particles can be focused to a full-width at half maximum diameter of 4.2 μm, and we demonstrate the use of such a nozzle for injecting viruses into a micro-focused soft-X-ray FEL beam.

Original languageEnglish (US)
Article number041717
JournalStructural Dynamics
Volume2
Issue number4
DOIs
StatePublished - Jul 1 2015

Fingerprint

convergent nozzles
X ray lasers
Free electron lasers
Aerosols
injectors
free electron lasers
Particles (particulate matter)
Nozzles
aerosols
Imaging techniques
X rays
nozzles
x rays
x ray lasers
orifices
viruses
Orifices
Full width at half maximum
Viruses
high resolution

ASJC Scopus subject areas

  • Condensed Matter Physics
  • Instrumentation
  • Radiation
  • Spectroscopy

Cite this

Kirian, R., Awel, S., Eckerskorn, N., Fleckenstein, H., Wiedorn, M., Adriano, L., ... Chapman, H. N. (2015). Simple convergent-nozzle aerosol injector for single-particle diffractive imaging with X-ray free-electron lasers. Structural Dynamics, 2(4), [041717]. https://doi.org/10.1063/1.4922648

Simple convergent-nozzle aerosol injector for single-particle diffractive imaging with X-ray free-electron lasers. / Kirian, Richard; Awel, S.; Eckerskorn, N.; Fleckenstein, H.; Wiedorn, M.; Adriano, L.; Bajt, S.; Barthelmess, M.; Bean, R.; Beyerlein, K. R.; Chavas, L. M G; Domaracky, M.; Heymann, M.; Horke, D. A.; Knoska, J.; Metz, M.; Morgan, A.; Oberthuer, D.; Roth, N.; Sato, T.; Xavier, P. L.; Yefanov, O.; Rode, A. V.; Küpper, J.; Chapman, H. N.

In: Structural Dynamics, Vol. 2, No. 4, 041717, 01.07.2015.

Research output: Contribution to journalArticle

Kirian, R, Awel, S, Eckerskorn, N, Fleckenstein, H, Wiedorn, M, Adriano, L, Bajt, S, Barthelmess, M, Bean, R, Beyerlein, KR, Chavas, LMG, Domaracky, M, Heymann, M, Horke, DA, Knoska, J, Metz, M, Morgan, A, Oberthuer, D, Roth, N, Sato, T, Xavier, PL, Yefanov, O, Rode, AV, Küpper, J & Chapman, HN 2015, 'Simple convergent-nozzle aerosol injector for single-particle diffractive imaging with X-ray free-electron lasers', Structural Dynamics, vol. 2, no. 4, 041717. https://doi.org/10.1063/1.4922648
Kirian, Richard ; Awel, S. ; Eckerskorn, N. ; Fleckenstein, H. ; Wiedorn, M. ; Adriano, L. ; Bajt, S. ; Barthelmess, M. ; Bean, R. ; Beyerlein, K. R. ; Chavas, L. M G ; Domaracky, M. ; Heymann, M. ; Horke, D. A. ; Knoska, J. ; Metz, M. ; Morgan, A. ; Oberthuer, D. ; Roth, N. ; Sato, T. ; Xavier, P. L. ; Yefanov, O. ; Rode, A. V. ; Küpper, J. ; Chapman, H. N. / Simple convergent-nozzle aerosol injector for single-particle diffractive imaging with X-ray free-electron lasers. In: Structural Dynamics. 2015 ; Vol. 2, No. 4.
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