Simple convergent-nozzle aerosol injector for single-particle diffractive imaging with X-ray free-electron lasers

Richard Kirian, S. Awel, N. Eckerskorn, H. Fleckenstein, M. Wiedorn, L. Adriano, S. Bajt, M. Barthelmess, R. Bean, K. R. Beyerlein, L. M G Chavas, M. Domaracky, M. Heymann, D. A. Horke, J. Knoska, M. Metz, A. Morgan, D. Oberthuer, N. Roth, T. SatoP. L. Xavier, O. Yefanov, A. V. Rode, J. Küpper, H. N. Chapman

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

A major challenge in high-resolution x-ray free-electron laser-based coherent diffractive imaging is the development of aerosol injectors that can efficiently deliver particles to the peak intensity of the focused X-ray beam. Here, we consider the use of a simple convergent-orifice nozzle for producing tightly focused beams of particles. Through optical imaging we show that 0.5 μm particles can be focused to a full-width at half maximum diameter of 4.2 μm, and we demonstrate the use of such a nozzle for injecting viruses into a micro-focused soft-X-ray FEL beam.

Original languageEnglish (US)
Article number041717
JournalStructural Dynamics
Volume2
Issue number4
DOIs
StatePublished - Jul 1 2015

ASJC Scopus subject areas

  • Radiation
  • Instrumentation
  • Condensed Matter Physics
  • Spectroscopy

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