Similar Pathogen Targets in Arabidopsis thaliana and Homo sapiens Protein Networks

Paulo Shakarian, J. Kenneth Wickiser

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

We study the behavior of pathogens on host protein networks for humans and Arabidopsis - noting striking similarities. Specifically, we preform k-shell decomposition analysis on these networks - which groups the proteins into various "shells" based on network structure. We observe that shells with a higher average degree are more highly targeted (with a power-law relationship) and that highly targeted nodes lie in shells closer to the inner-core of the network. Additionally, we also note that the inner core of the network is significantly under-targeted. We show that these core proteins may have a role in intra-cellular communication and hypothesize that they are less attacked to ensure survival of the host. This may explain why certain high-degree proteins are not significantly attacked.

Original languageEnglish (US)
Article numbere45154
JournalPloS one
Volume7
Issue number9
DOIs
StatePublished - Sep 21 2012

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General

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