Abstract

Recent research in the domain of single molecule biosensors aims at using silicon pore systems for the electrical detection of charged entities. Detection is achieved through resistive pulse measurements also known as Coulter counting. This work demonstrates the use of silicon based cylindrical micropores which can be used to detect biomolecules with high selectivity and robustness. The micropores used in the experiment were patterned using semiconductor processing techniques to have a final diameter of 5um and a length of 30um on a siliconsubstrate. The probes used in the study were silica beads which have been functionalized to detect two types of protein immunocomplexes: (i) biotin-avidin and (ii) immunoglobulin-G using its specific antibody within the silicon micropore system.

Original languageEnglish (US)
Title of host publicationProceedings of the ASME International Mechanical Engineering Congress and Exposition 2009, IMECE 2009
PublisherAmerican Society of Mechanical Engineers (ASME)
Pages263-270
Number of pages8
ISBN (Print)9780791843758
DOIs
StatePublished - Jan 1 2010
Event2009 ASME International Mechanical Engineering Congress and Exposition, IMECE2009 - Lake Buena Vista, FL, United States
Duration: Nov 13 2009Nov 19 2009

Publication series

NameASME International Mechanical Engineering Congress and Exposition, Proceedings
Volume2

Other

Other2009 ASME International Mechanical Engineering Congress and Exposition, IMECE2009
CountryUnited States
CityLake Buena Vista, FL
Period11/13/0911/19/09

ASJC Scopus subject areas

  • Mechanical Engineering

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  • Cite this

    Mathew, T., Joshi, P., Prasad, S., Goryll, M., Spanias, A., & Thornton, T. (2010). Silicon based pore systems for emerging biosensor applications. In Proceedings of the ASME International Mechanical Engineering Congress and Exposition 2009, IMECE 2009 (pp. 263-270). (ASME International Mechanical Engineering Congress and Exposition, Proceedings; Vol. 2). American Society of Mechanical Engineers (ASME). https://doi.org/10.1115/IMECE2009-11707