Abstract

In this paper we present a method to fabricate an aperture in a silicon wafer that can be used to suspend a freestanding lipid bilayer membrane. The design offers the feature of scalability of the aperture size into the submicron range. Lipid bilayer membranes formed across the aperture in the oxidized silicon substrate show a gigaohm sealing resistance. The stability of these membranes allowed the insertion of a nanometer-sized ion channel protein (OmpF porin) and the measurement of voltage dependent gating that can be expected from a working porin ion channel.

Original languageEnglish (US)
Pages (from-to)451-457
Number of pages7
JournalSuperlattices and Microstructures
Volume34
Issue number3-6
DOIs
StatePublished - Sep 2003

Fingerprint

Porins
Lipid bilayers
Silicon
Membrane Lipids
Ion Channels
apertures
membranes
Membranes
lipids
sensors
Sensors
Ions
silicon
Silicon wafers
Scalability
sealing
insertion
Electric potential
Substrates
wafers

Keywords

  • Biosensors
  • Lipid bilayers
  • Silicon devices

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics

Cite this

Silicon-based ion channel sensor. / Goryll, Michael; Wilk, S.; Laws, G. M.; Thornton, Trevor; Goodnick, Stephen; Saraniti, Marco; Tang, J.; Eisenberg, R. S.

In: Superlattices and Microstructures, Vol. 34, No. 3-6, 09.2003, p. 451-457.

Research output: Contribution to journalArticle

Goryll, Michael ; Wilk, S. ; Laws, G. M. ; Thornton, Trevor ; Goodnick, Stephen ; Saraniti, Marco ; Tang, J. ; Eisenberg, R. S. / Silicon-based ion channel sensor. In: Superlattices and Microstructures. 2003 ; Vol. 34, No. 3-6. pp. 451-457.
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