Shifting fitness landscapes in response to altered environments

Ryan T. Hietpas, Claudia Bank, Jeffrey Jensen, Daniel N A Bolon

Research output: Contribution to journalArticle

58 Citations (Scopus)

Abstract

The role of adaptation in molecular evolution has been contentious for decades. Here, we shed light on the adaptive potential in Saccharomyces cerevisiae by presenting systematic fitness measurements for all possible point mutations in a region of Hsp90 under four environmental conditions. Under elevated salinity, we observe numerous beneficial mutations with growth advantages up to 7% relative to the wild type. All of these beneficial mutations were observed to be associated with high costs of adaptation. We thus demonstrate that an essential protein can harbor adaptive potential upon an environmental challenge, and report a remarkable fit of the data to a version of Fisher's geometric model that focuses on the fitness trade-offs between mutations in different environments.

Original languageEnglish (US)
Pages (from-to)3512-3522
Number of pages11
JournalEvolution
Volume67
Issue number12
DOIs
StatePublished - Dec 2013
Externally publishedYes

Fingerprint

mutation
fitness
Mutation
Molecular Evolution
Salinity
point mutation
Point Mutation
Saccharomyces cerevisiae
salinity
Costs and Cost Analysis
harbor
environmental factors
environmental conditions
Growth
protein
Proteins
proteins
cost

Keywords

  • Adaptation
  • Adaptive walk
  • Distribution of fitness effects
  • Experimental evolution
  • Fisher's geometric model

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Genetics
  • Agricultural and Biological Sciences(all)

Cite this

Shifting fitness landscapes in response to altered environments. / Hietpas, Ryan T.; Bank, Claudia; Jensen, Jeffrey; Bolon, Daniel N A.

In: Evolution, Vol. 67, No. 12, 12.2013, p. 3512-3522.

Research output: Contribution to journalArticle

Hietpas, RT, Bank, C, Jensen, J & Bolon, DNA 2013, 'Shifting fitness landscapes in response to altered environments', Evolution, vol. 67, no. 12, pp. 3512-3522. https://doi.org/10.1111/evo.12207
Hietpas, Ryan T. ; Bank, Claudia ; Jensen, Jeffrey ; Bolon, Daniel N A. / Shifting fitness landscapes in response to altered environments. In: Evolution. 2013 ; Vol. 67, No. 12. pp. 3512-3522.
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