Shifting fitness landscapes in response to altered environments

Ryan T. Hietpas, Claudia Bank, Jeffrey D. Jensen, Daniel N.A. Bolon

Research output: Contribution to journalArticle

65 Scopus citations

Abstract

The role of adaptation in molecular evolution has been contentious for decades. Here, we shed light on the adaptive potential in Saccharomyces cerevisiae by presenting systematic fitness measurements for all possible point mutations in a region of Hsp90 under four environmental conditions. Under elevated salinity, we observe numerous beneficial mutations with growth advantages up to 7% relative to the wild type. All of these beneficial mutations were observed to be associated with high costs of adaptation. We thus demonstrate that an essential protein can harbor adaptive potential upon an environmental challenge, and report a remarkable fit of the data to a version of Fisher's geometric model that focuses on the fitness trade-offs between mutations in different environments.

Original languageEnglish (US)
Pages (from-to)3512-3522
Number of pages11
JournalEvolution
Volume67
Issue number12
DOIs
StatePublished - Dec 2013

Keywords

  • Adaptation
  • Adaptive walk
  • Distribution of fitness effects
  • Experimental evolution
  • Fisher's geometric model

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Genetics
  • Agricultural and Biological Sciences(all)

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