TY - GEN
T1 - Shape-based analysis of right ventricular dysfunction associated with acute pulmonary embolism
AU - Tajbakhsh, Nima
AU - Xue, Wenzhe
AU - Wu, Hong
AU - Liang, Jianming
AU - McMahon, Eileen M.
AU - Belohlavek, Marek
PY - 2012/5/14
Y1 - 2012/5/14
N2 - Acute pulmonary embolism (APE) is known as one of the major causes of sudden death. However, high level of mortality caused by APE can be reduced, if detected in early stages of development. Hence, biomarkers capable of early detection of APE are of utmost importance. This study investigates how APE affects the biomechanics of the cardiac right ventricle (RV), taking one step towards developing functional biomarkers for early diagnosis and determination of prognosis of APE. To that end, we conducted a pilot study in pigs, which revealed the following major changes due to the severe RV afterload caused by APE: (1) waving paradoxical motion of the RV inner boundary, (2) decrease in local curvature of the septum, (3) lower positive correlation between the movement of inner boundaries of the septal and free walls of the RV, (4) slower blood ejection by the RV, and (5) discontinuous movement observed particularly in the middle of the RV septal wall.
AB - Acute pulmonary embolism (APE) is known as one of the major causes of sudden death. However, high level of mortality caused by APE can be reduced, if detected in early stages of development. Hence, biomarkers capable of early detection of APE are of utmost importance. This study investigates how APE affects the biomechanics of the cardiac right ventricle (RV), taking one step towards developing functional biomarkers for early diagnosis and determination of prognosis of APE. To that end, we conducted a pilot study in pigs, which revealed the following major changes due to the severe RV afterload caused by APE: (1) waving paradoxical motion of the RV inner boundary, (2) decrease in local curvature of the septum, (3) lower positive correlation between the movement of inner boundaries of the septal and free walls of the RV, (4) slower blood ejection by the RV, and (5) discontinuous movement observed particularly in the middle of the RV septal wall.
KW - Acute pulmonary embolism
KW - Right ventricle
KW - Shape-based analysis
UR - http://www.scopus.com/inward/record.url?scp=84860782392&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84860782392&partnerID=8YFLogxK
U2 - 10.1117/12.913299
DO - 10.1117/12.913299
M3 - Conference contribution
AN - SCOPUS:84860782392
SN - 9780819489661
T3 - Progress in Biomedical Optics and Imaging - Proceedings of SPIE
BT - Medical Imaging 2012
T2 - Medical Imaging 2012: Biomedical Applications in Molecular, Structural, and Functional Imaging
Y2 - 5 February 2012 through 7 February 2012
ER -