Shape-based analysis of right ventricular dysfunction associated with acute pulmonary embolism

Nima Tajbakhsh, Wenzhe Xue, Hong Wu, Jianming Liang, Eileen M. McMahon, Marek Belohlavek

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Abstract

    Acute pulmonary embolism (APE) is known as one of the major causes of sudden death. However, high level of mortality caused by APE can be reduced, if detected in early stages of development. Hence, biomarkers capable of early detection of APE are of utmost importance. This study investigates how APE affects the biomechanics of the cardiac right ventricle (RV), taking one step towards developing functional biomarkers for early diagnosis and determination of prognosis of APE. To that end, we conducted a pilot study in pigs, which revealed the following major changes due to the severe RV afterload caused by APE: (1) waving paradoxical motion of the RV inner boundary, (2) decrease in local curvature of the septum, (3) lower positive correlation between the movement of inner boundaries of the septal and free walls of the RV, (4) slower blood ejection by the RV, and (5) discontinuous movement observed particularly in the middle of the RV septal wall.

    Original languageEnglish (US)
    Title of host publicationProgress in Biomedical Optics and Imaging - Proceedings of SPIE
    Volume8317
    DOIs
    StatePublished - 2012
    EventMedical Imaging 2012: Biomedical Applications in Molecular, Structural, and Functional Imaging - San Diego, CA, United States
    Duration: Feb 5 2012Feb 7 2012

    Other

    OtherMedical Imaging 2012: Biomedical Applications in Molecular, Structural, and Functional Imaging
    CountryUnited States
    CitySan Diego, CA
    Period2/5/122/7/12

    Fingerprint

    embolisms
    Right Ventricular Dysfunction
    Biomarkers
    Pulmonary Embolism
    Heart Ventricles
    Biomechanics
    Blood
    biomarkers
    cardiac ventricles
    biodynamics
    septum
    swine
    prognosis
    mortality
    death
    ejection
    blood
    Sudden Death
    Biomechanical Phenomena
    curvature

    Keywords

    • Acute pulmonary embolism
    • Right ventricle
    • Shape-based analysis

    ASJC Scopus subject areas

    • Atomic and Molecular Physics, and Optics
    • Electronic, Optical and Magnetic Materials
    • Biomaterials
    • Radiology Nuclear Medicine and imaging

    Cite this

    Tajbakhsh, N., Xue, W., Wu, H., Liang, J., McMahon, E. M., & Belohlavek, M. (2012). Shape-based analysis of right ventricular dysfunction associated with acute pulmonary embolism. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE (Vol. 8317). [83170G] https://doi.org/10.1117/12.913299

    Shape-based analysis of right ventricular dysfunction associated with acute pulmonary embolism. / Tajbakhsh, Nima; Xue, Wenzhe; Wu, Hong; Liang, Jianming; McMahon, Eileen M.; Belohlavek, Marek.

    Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 8317 2012. 83170G.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Tajbakhsh, N, Xue, W, Wu, H, Liang, J, McMahon, EM & Belohlavek, M 2012, Shape-based analysis of right ventricular dysfunction associated with acute pulmonary embolism. in Progress in Biomedical Optics and Imaging - Proceedings of SPIE. vol. 8317, 83170G, Medical Imaging 2012: Biomedical Applications in Molecular, Structural, and Functional Imaging, San Diego, CA, United States, 2/5/12. https://doi.org/10.1117/12.913299
    Tajbakhsh N, Xue W, Wu H, Liang J, McMahon EM, Belohlavek M. Shape-based analysis of right ventricular dysfunction associated with acute pulmonary embolism. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 8317. 2012. 83170G https://doi.org/10.1117/12.913299
    Tajbakhsh, Nima ; Xue, Wenzhe ; Wu, Hong ; Liang, Jianming ; McMahon, Eileen M. ; Belohlavek, Marek. / Shape-based analysis of right ventricular dysfunction associated with acute pulmonary embolism. Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 8317 2012.
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