Shape-based analysis of right ventricular dysfunction associated with acute pulmonary embolism

Nima Tajbakhsh, Wenzhe Xue, Hong Wu, Jianming Liang, Eileen M. McMahon, Marek Belohlavek

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Abstract

    Acute pulmonary embolism (APE) is known as one of the major causes of sudden death. However, high level of mortality caused by APE can be reduced, if detected in early stages of development. Hence, biomarkers capable of early detection of APE are of utmost importance. This study investigates how APE affects the biomechanics of the cardiac right ventricle (RV), taking one step towards developing functional biomarkers for early diagnosis and determination of prognosis of APE. To that end, we conducted a pilot study in pigs, which revealed the following major changes due to the severe RV afterload caused by APE: (1) waving paradoxical motion of the RV inner boundary, (2) decrease in local curvature of the septum, (3) lower positive correlation between the movement of inner boundaries of the septal and free walls of the RV, (4) slower blood ejection by the RV, and (5) discontinuous movement observed particularly in the middle of the RV septal wall.

    Original languageEnglish (US)
    Title of host publicationMedical Imaging 2012
    Subtitle of host publicationBiomedical Applications in Molecular, Structural, and Functional Imaging
    DOIs
    StatePublished - May 14 2012
    EventMedical Imaging 2012: Biomedical Applications in Molecular, Structural, and Functional Imaging - San Diego, CA, United States
    Duration: Feb 5 2012Feb 7 2012

    Publication series

    NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
    Volume8317
    ISSN (Print)1605-7422

    Other

    OtherMedical Imaging 2012: Biomedical Applications in Molecular, Structural, and Functional Imaging
    CountryUnited States
    CitySan Diego, CA
    Period2/5/122/7/12

    Keywords

    • Acute pulmonary embolism
    • Right ventricle
    • Shape-based analysis

    ASJC Scopus subject areas

    • Electronic, Optical and Magnetic Materials
    • Biomaterials
    • Atomic and Molecular Physics, and Optics
    • Radiology Nuclear Medicine and imaging

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  • Cite this

    Tajbakhsh, N., Xue, W., Wu, H., Liang, J., McMahon, E. M., & Belohlavek, M. (2012). Shape-based analysis of right ventricular dysfunction associated with acute pulmonary embolism. In Medical Imaging 2012: Biomedical Applications in Molecular, Structural, and Functional Imaging [83170G] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 8317). https://doi.org/10.1117/12.913299