Serum lipid and fat-soluble vitamin levels in primary sclerosing cholangitis

R. A. Jorgensen, Keith Lindor, J. S. Sartin, N. F. LaRusso, R. H. Wiesner

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

We reviewed the initial lipid and fat-soluble vitamin levels in 56 patients with primary sclerosing cholangitis (PSC) enrolled in a randomized, placebo-controlled trial evaluating ursodeoxycholic acid. We also evaluated lipid and vitamin levels in a group of 87 patients with advanced PSC being evaluated for liver transplantation. Of the patients entering the therapeutic trial, 41% had total serum cholesterol levels greater than the 95th percentile, whereas only 20% had high density lipoprotein cholesterol levels above normal, and only one (2%) had an elevated triglyceride level. Total cholesterol levels were correlated with serum bilirubin levels and were lower in early versus later histologic stages (206 ± 61 vs. 248 ± 79, p = 0.04). Of the 87 pretransplant patients, 29% had elevated serum cholesterol levels and 17% had elevated serum triglyceride levels. Total serum cholesterol levels correlated inversely with total serum bilirubin levels in this group. In patients in the therapeutic trial, vitamin A deficiency was seen in 40%, vitamin D deficiency in 14%, and vitamin E deficiency in 2% of those tested. More prominent deficiencies of fat-soluble vitamins occurred in the pretransplant group of patients, with 82% deficient in vitamin A, 57% deficient in vitamin D, and 43% deficient in vitamin E. We conclude that hypercholesterolemia and fat-soluble vitamin deficiencies are frequent in patients with PSC and are more common with more severe disease. Patients with PSC, especially with advanced liver disease, should be screened for fat- soluble vitamin deficiencies and supplemented accordingly.

Original languageEnglish (US)
Pages (from-to)215-219
Number of pages5
JournalJournal of Clinical Gastroenterology
Volume20
Issue number3
StatePublished - 1995
Externally publishedYes

Fingerprint

Sclerosing Cholangitis
Vitamins
Fats
Lipids
Serum
Avitaminosis
Cholesterol
Hypercholesterolemia
Bilirubin
Triglycerides
Vitamin E Deficiency
Vitamin A Deficiency
Ursodeoxycholic Acid
Vitamin D Deficiency
Vitamin A
Vitamin E
Vitamin D
Liver Transplantation
HDL Cholesterol
Liver Diseases

Keywords

  • Fat-soluble vitamin levels
  • Primary sclerosing cholangitis
  • Serum lipid

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Jorgensen, R. A., Lindor, K., Sartin, J. S., LaRusso, N. F., & Wiesner, R. H. (1995). Serum lipid and fat-soluble vitamin levels in primary sclerosing cholangitis. Journal of Clinical Gastroenterology, 20(3), 215-219.

Serum lipid and fat-soluble vitamin levels in primary sclerosing cholangitis. / Jorgensen, R. A.; Lindor, Keith; Sartin, J. S.; LaRusso, N. F.; Wiesner, R. H.

In: Journal of Clinical Gastroenterology, Vol. 20, No. 3, 1995, p. 215-219.

Research output: Contribution to journalArticle

Jorgensen, RA, Lindor, K, Sartin, JS, LaRusso, NF & Wiesner, RH 1995, 'Serum lipid and fat-soluble vitamin levels in primary sclerosing cholangitis', Journal of Clinical Gastroenterology, vol. 20, no. 3, pp. 215-219.
Jorgensen, R. A. ; Lindor, Keith ; Sartin, J. S. ; LaRusso, N. F. ; Wiesner, R. H. / Serum lipid and fat-soluble vitamin levels in primary sclerosing cholangitis. In: Journal of Clinical Gastroenterology. 1995 ; Vol. 20, No. 3. pp. 215-219.
@article{3ff5121818ba4bceb96365f0149b0f8f,
title = "Serum lipid and fat-soluble vitamin levels in primary sclerosing cholangitis",
abstract = "We reviewed the initial lipid and fat-soluble vitamin levels in 56 patients with primary sclerosing cholangitis (PSC) enrolled in a randomized, placebo-controlled trial evaluating ursodeoxycholic acid. We also evaluated lipid and vitamin levels in a group of 87 patients with advanced PSC being evaluated for liver transplantation. Of the patients entering the therapeutic trial, 41{\%} had total serum cholesterol levels greater than the 95th percentile, whereas only 20{\%} had high density lipoprotein cholesterol levels above normal, and only one (2{\%}) had an elevated triglyceride level. Total cholesterol levels were correlated with serum bilirubin levels and were lower in early versus later histologic stages (206 ± 61 vs. 248 ± 79, p = 0.04). Of the 87 pretransplant patients, 29{\%} had elevated serum cholesterol levels and 17{\%} had elevated serum triglyceride levels. Total serum cholesterol levels correlated inversely with total serum bilirubin levels in this group. In patients in the therapeutic trial, vitamin A deficiency was seen in 40{\%}, vitamin D deficiency in 14{\%}, and vitamin E deficiency in 2{\%} of those tested. More prominent deficiencies of fat-soluble vitamins occurred in the pretransplant group of patients, with 82{\%} deficient in vitamin A, 57{\%} deficient in vitamin D, and 43{\%} deficient in vitamin E. We conclude that hypercholesterolemia and fat-soluble vitamin deficiencies are frequent in patients with PSC and are more common with more severe disease. Patients with PSC, especially with advanced liver disease, should be screened for fat- soluble vitamin deficiencies and supplemented accordingly.",
keywords = "Fat-soluble vitamin levels, Primary sclerosing cholangitis, Serum lipid",
author = "Jorgensen, {R. A.} and Keith Lindor and Sartin, {J. S.} and LaRusso, {N. F.} and Wiesner, {R. H.}",
year = "1995",
language = "English (US)",
volume = "20",
pages = "215--219",
journal = "Journal of Clinical Gastroenterology",
issn = "0192-0790",
publisher = "Lippincott Williams and Wilkins",
number = "3",

}

TY - JOUR

T1 - Serum lipid and fat-soluble vitamin levels in primary sclerosing cholangitis

AU - Jorgensen, R. A.

AU - Lindor, Keith

AU - Sartin, J. S.

AU - LaRusso, N. F.

AU - Wiesner, R. H.

PY - 1995

Y1 - 1995

N2 - We reviewed the initial lipid and fat-soluble vitamin levels in 56 patients with primary sclerosing cholangitis (PSC) enrolled in a randomized, placebo-controlled trial evaluating ursodeoxycholic acid. We also evaluated lipid and vitamin levels in a group of 87 patients with advanced PSC being evaluated for liver transplantation. Of the patients entering the therapeutic trial, 41% had total serum cholesterol levels greater than the 95th percentile, whereas only 20% had high density lipoprotein cholesterol levels above normal, and only one (2%) had an elevated triglyceride level. Total cholesterol levels were correlated with serum bilirubin levels and were lower in early versus later histologic stages (206 ± 61 vs. 248 ± 79, p = 0.04). Of the 87 pretransplant patients, 29% had elevated serum cholesterol levels and 17% had elevated serum triglyceride levels. Total serum cholesterol levels correlated inversely with total serum bilirubin levels in this group. In patients in the therapeutic trial, vitamin A deficiency was seen in 40%, vitamin D deficiency in 14%, and vitamin E deficiency in 2% of those tested. More prominent deficiencies of fat-soluble vitamins occurred in the pretransplant group of patients, with 82% deficient in vitamin A, 57% deficient in vitamin D, and 43% deficient in vitamin E. We conclude that hypercholesterolemia and fat-soluble vitamin deficiencies are frequent in patients with PSC and are more common with more severe disease. Patients with PSC, especially with advanced liver disease, should be screened for fat- soluble vitamin deficiencies and supplemented accordingly.

AB - We reviewed the initial lipid and fat-soluble vitamin levels in 56 patients with primary sclerosing cholangitis (PSC) enrolled in a randomized, placebo-controlled trial evaluating ursodeoxycholic acid. We also evaluated lipid and vitamin levels in a group of 87 patients with advanced PSC being evaluated for liver transplantation. Of the patients entering the therapeutic trial, 41% had total serum cholesterol levels greater than the 95th percentile, whereas only 20% had high density lipoprotein cholesterol levels above normal, and only one (2%) had an elevated triglyceride level. Total cholesterol levels were correlated with serum bilirubin levels and were lower in early versus later histologic stages (206 ± 61 vs. 248 ± 79, p = 0.04). Of the 87 pretransplant patients, 29% had elevated serum cholesterol levels and 17% had elevated serum triglyceride levels. Total serum cholesterol levels correlated inversely with total serum bilirubin levels in this group. In patients in the therapeutic trial, vitamin A deficiency was seen in 40%, vitamin D deficiency in 14%, and vitamin E deficiency in 2% of those tested. More prominent deficiencies of fat-soluble vitamins occurred in the pretransplant group of patients, with 82% deficient in vitamin A, 57% deficient in vitamin D, and 43% deficient in vitamin E. We conclude that hypercholesterolemia and fat-soluble vitamin deficiencies are frequent in patients with PSC and are more common with more severe disease. Patients with PSC, especially with advanced liver disease, should be screened for fat- soluble vitamin deficiencies and supplemented accordingly.

KW - Fat-soluble vitamin levels

KW - Primary sclerosing cholangitis

KW - Serum lipid

UR - http://www.scopus.com/inward/record.url?scp=0028965721&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028965721&partnerID=8YFLogxK

M3 - Article

VL - 20

SP - 215

EP - 219

JO - Journal of Clinical Gastroenterology

JF - Journal of Clinical Gastroenterology

SN - 0192-0790

IS - 3

ER -