Serum ferritin and risk of the metabolic syndrome in U.S. adults

Megan Jehn, Jeanne M. Clark, Eliseo Guallar

Research output: Contribution to journalArticle

274 Citations (Scopus)

Abstract

OBJECTIVE - We examined the relationship among iron stores, the metabolic syndrome, and insulin resistance. RESEARCH DESIGN AND METHODS - We conducted a cross-sectional study of 6,044 adults >20 years of age who participated in the Third National Health and Nutrition Examination Survey. Metabolic syndrome was defined as the presence of at least three of the following: elevated blood pressure, low HDL cholesterol, elevated serum triglycerides, elevated plasma glucose, and abdominal obesity. Insulin resistance was estimated using homeostasis model assessment (for insulin resistance), fasting insulin, and triglyceride-to-HDL cholesterol ratio. RESULTS - After excluding individuals with likely hemochromatosis, mean serum ferritin values in premenopausal women, postmenopausal women, and men were 33.6, 93.4, and 139.9 μg/l, respectively. Metabolic syndrome was more common in those with the highest compared with the lowest levels of serum ferritin in premenopausal women (14.9 vs. 6.4%, P = 0.002), postmenopausal women (47.5 vs. 28.2%, P < 0.001), and men (27.3 vs. 13.8%, P < 0.001). Insulin resistance also increased across quartiles of serum ferritin for men and postmenopausal women and persisted after adjustment for age, race/ethnicity, C-reactive protein, smoking, alcohol intake, and BMI. CONCLUSIONS - Elevated iron stores were positively associated with the prevalence of the metabolic syndrome and with insulin resistance.

Original languageEnglish (US)
Pages (from-to)2422-2428
Number of pages7
JournalDiabetes Care
Volume27
Issue number10
DOIs
StatePublished - Oct 2004
Externally publishedYes

Fingerprint

Ferritins
Insulin Resistance
Serum
Triglycerides
Hypoalphalipoproteinemias
Iron
Hemochromatosis
Abdominal Obesity
Nutrition Surveys
C-Reactive Protein
HDL Cholesterol
Fasting
Homeostasis
Research Design
Cross-Sectional Studies
Smoking
Alcohols
Insulin
Blood Pressure
Glucose

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

Serum ferritin and risk of the metabolic syndrome in U.S. adults. / Jehn, Megan; Clark, Jeanne M.; Guallar, Eliseo.

In: Diabetes Care, Vol. 27, No. 10, 10.2004, p. 2422-2428.

Research output: Contribution to journalArticle

Jehn, Megan ; Clark, Jeanne M. ; Guallar, Eliseo. / Serum ferritin and risk of the metabolic syndrome in U.S. adults. In: Diabetes Care. 2004 ; Vol. 27, No. 10. pp. 2422-2428.
@article{fd8cdeeb7ae040bab6a6e799c8e95af2,
title = "Serum ferritin and risk of the metabolic syndrome in U.S. adults",
abstract = "OBJECTIVE - We examined the relationship among iron stores, the metabolic syndrome, and insulin resistance. RESEARCH DESIGN AND METHODS - We conducted a cross-sectional study of 6,044 adults >20 years of age who participated in the Third National Health and Nutrition Examination Survey. Metabolic syndrome was defined as the presence of at least three of the following: elevated blood pressure, low HDL cholesterol, elevated serum triglycerides, elevated plasma glucose, and abdominal obesity. Insulin resistance was estimated using homeostasis model assessment (for insulin resistance), fasting insulin, and triglyceride-to-HDL cholesterol ratio. RESULTS - After excluding individuals with likely hemochromatosis, mean serum ferritin values in premenopausal women, postmenopausal women, and men were 33.6, 93.4, and 139.9 μg/l, respectively. Metabolic syndrome was more common in those with the highest compared with the lowest levels of serum ferritin in premenopausal women (14.9 vs. 6.4{\%}, P = 0.002), postmenopausal women (47.5 vs. 28.2{\%}, P < 0.001), and men (27.3 vs. 13.8{\%}, P < 0.001). Insulin resistance also increased across quartiles of serum ferritin for men and postmenopausal women and persisted after adjustment for age, race/ethnicity, C-reactive protein, smoking, alcohol intake, and BMI. CONCLUSIONS - Elevated iron stores were positively associated with the prevalence of the metabolic syndrome and with insulin resistance.",
author = "Megan Jehn and Clark, {Jeanne M.} and Eliseo Guallar",
year = "2004",
month = "10",
doi = "10.2337/diacare.27.10.2422",
language = "English (US)",
volume = "27",
pages = "2422--2428",
journal = "Diabetes Care",
issn = "1935-5548",
publisher = "American Diabetes Association Inc.",
number = "10",

}

TY - JOUR

T1 - Serum ferritin and risk of the metabolic syndrome in U.S. adults

AU - Jehn, Megan

AU - Clark, Jeanne M.

AU - Guallar, Eliseo

PY - 2004/10

Y1 - 2004/10

N2 - OBJECTIVE - We examined the relationship among iron stores, the metabolic syndrome, and insulin resistance. RESEARCH DESIGN AND METHODS - We conducted a cross-sectional study of 6,044 adults >20 years of age who participated in the Third National Health and Nutrition Examination Survey. Metabolic syndrome was defined as the presence of at least three of the following: elevated blood pressure, low HDL cholesterol, elevated serum triglycerides, elevated plasma glucose, and abdominal obesity. Insulin resistance was estimated using homeostasis model assessment (for insulin resistance), fasting insulin, and triglyceride-to-HDL cholesterol ratio. RESULTS - After excluding individuals with likely hemochromatosis, mean serum ferritin values in premenopausal women, postmenopausal women, and men were 33.6, 93.4, and 139.9 μg/l, respectively. Metabolic syndrome was more common in those with the highest compared with the lowest levels of serum ferritin in premenopausal women (14.9 vs. 6.4%, P = 0.002), postmenopausal women (47.5 vs. 28.2%, P < 0.001), and men (27.3 vs. 13.8%, P < 0.001). Insulin resistance also increased across quartiles of serum ferritin for men and postmenopausal women and persisted after adjustment for age, race/ethnicity, C-reactive protein, smoking, alcohol intake, and BMI. CONCLUSIONS - Elevated iron stores were positively associated with the prevalence of the metabolic syndrome and with insulin resistance.

AB - OBJECTIVE - We examined the relationship among iron stores, the metabolic syndrome, and insulin resistance. RESEARCH DESIGN AND METHODS - We conducted a cross-sectional study of 6,044 adults >20 years of age who participated in the Third National Health and Nutrition Examination Survey. Metabolic syndrome was defined as the presence of at least three of the following: elevated blood pressure, low HDL cholesterol, elevated serum triglycerides, elevated plasma glucose, and abdominal obesity. Insulin resistance was estimated using homeostasis model assessment (for insulin resistance), fasting insulin, and triglyceride-to-HDL cholesterol ratio. RESULTS - After excluding individuals with likely hemochromatosis, mean serum ferritin values in premenopausal women, postmenopausal women, and men were 33.6, 93.4, and 139.9 μg/l, respectively. Metabolic syndrome was more common in those with the highest compared with the lowest levels of serum ferritin in premenopausal women (14.9 vs. 6.4%, P = 0.002), postmenopausal women (47.5 vs. 28.2%, P < 0.001), and men (27.3 vs. 13.8%, P < 0.001). Insulin resistance also increased across quartiles of serum ferritin for men and postmenopausal women and persisted after adjustment for age, race/ethnicity, C-reactive protein, smoking, alcohol intake, and BMI. CONCLUSIONS - Elevated iron stores were positively associated with the prevalence of the metabolic syndrome and with insulin resistance.

UR - http://www.scopus.com/inward/record.url?scp=4644243396&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=4644243396&partnerID=8YFLogxK

U2 - 10.2337/diacare.27.10.2422

DO - 10.2337/diacare.27.10.2422

M3 - Article

VL - 27

SP - 2422

EP - 2428

JO - Diabetes Care

JF - Diabetes Care

SN - 1935-5548

IS - 10

ER -