Sequence homologies among E. coli ribosomal proteins: Evidence for evolutionarily related groupings and internal duplications

R. A. Jue, N. W. Woodbury, R. F. Doolittle

Research output: Contribution to journalArticle

48 Scopus citations

Abstract

The complete or partial sequences of 47 E. coli ribosomal proteins described in the literature have been examined by computerized search and matching programs. In contrast to results previously reported by other investigators, sequence homologies were uncovered among some of these ribosomal proteins that are well beyond statistical expectations. Moreover, alignments of the most strongly homologous sequences suggested the existence of a network of family groupings. Several of these proteins also exhibit internal homologies, indicating that they have been elongated by a series of tandem duplications.

Original languageEnglish (US)
Pages (from-to)129-148
Number of pages20
JournalJournal of Molecular Evolution
Volume15
Issue number2
DOIs
StatePublished - Jun 1 1980
Externally publishedYes

Keywords

  • Computer sequence matching
  • Gene duplications
  • Homologous sequences
  • Protein evolution
  • Ribosomal proteins

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Molecular Biology
  • Genetics

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