Sequence alignment: Methods, models, concepts, and strategies

Michael S. Rosenberg

Research output: Book/ReportBook

39 Scopus citations

Abstract

The sequencing of the human genome involved thousands of scientists but used relatively few tools. Today, obtaining sequences is simpler, but aligning the sequences-making sure that sequences from one source are properly compared to those from other sources-remains a complicated but underappreciated aspect of comparative molecular biology. This volume, the first to focus on this crucial step in analyzing sequence data, is about the practice of alignment, the procedures by which alignments are established, and more importantly, how the outcomes of any alignment algorithm should be interpreted. Edited by Michael S. Rosenberg with essays by many of the field's leading experts, Sequence Alignment covers molecular causes, computational advances, approaches for assessing alignment quality, and philosophical underpinnings of the algorithms themselves.

Original languageEnglish (US)
PublisherUniversity of California Press
ISBN (Print)9780520256972
StatePublished - Mar 11 2009

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)

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