Separation Phenomena in Tailored Micro- and Nanofluidic Environments

Mukul Sonker, Daihyun Kim, Ana Egatz-Gomez, Alexandra Ros

Research output: Contribution to journalReview article

Abstract

Separations of bioanalytes require robust, effective, and selective migration phenomena. However, due to the complexity of biological matrices such as body fluids or tissue, these requirements are difficult to achieve. The separations field is thus constantly evolving to develop suitable methods to separate biomarkers and fractionate biospecimens for further interrogation of biomolecular content. Advances in the field of microfabrication allow the tailored generation of micro- and nanofluidic environments. These can be exploited to induce interactions and dynamics of biological species with the corresponding geometrical features, which in turn can be capitalized for novel separation approaches. This review provides an overview of several unique separation applications demonstrated in recent years in tailored micro- and nanofluidic environments. These include electrokinetic methods such as dielectrophoresis and electrophoresis, but also rather nonintuitive ratchet separation mechanisms, continuous flow separations, and fractionations such as deterministic lateral displacement, as well as methods employing entropic forces for separation.

Original languageEnglish (US)
Pages (from-to)475-500
Number of pages26
JournalAnnual Review of Analytical Chemistry
Volume12
DOIs
StatePublished - Jun 12 2019
Externally publishedYes

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Nanofluidics
Microfluidics
Electrophoresis
Flow separation
Microfabrication
Body fluids
Biomarkers
Fractionation
Tissue

Keywords

  • dielectrophoresis
  • displacement
  • electrophoresis
  • entropic traps
  • microstructure
  • migration
  • nanostructure
  • ratchet

ASJC Scopus subject areas

  • Analytical Chemistry

Cite this

Separation Phenomena in Tailored Micro- and Nanofluidic Environments. / Sonker, Mukul; Kim, Daihyun; Egatz-Gomez, Ana; Ros, Alexandra.

In: Annual Review of Analytical Chemistry, Vol. 12, 12.06.2019, p. 475-500.

Research output: Contribution to journalReview article

Sonker, Mukul ; Kim, Daihyun ; Egatz-Gomez, Ana ; Ros, Alexandra. / Separation Phenomena in Tailored Micro- and Nanofluidic Environments. In: Annual Review of Analytical Chemistry. 2019 ; Vol. 12. pp. 475-500.
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