Abstract

We report a microfluidic-based Surface Plasmon Resonance (SPR) biosensor for rapid, real-time detection of Thyroglobulin (Tg, a sensitive indicator of persistent or recurrent differentiated thyroid cancer with abnormal concentration higher than 3 ng/mL in undiluted human serum, using competitive adsorption of proteins and pattern recognition. The SPR biosensor produces unique patterns from multiple engineered sensing surfaces, and then Linear Discriminant Analysis (LDA) is used to differentiate these patterns. The microfluidic-based biosensor demonstrates the ability to detect 2 ng/mL Tg in undiluted serum with 91.7 % and 90.0 % classification confidence level for its sensitivity and selectivity, respectively.

Original languageEnglish (US)
Title of host publicationTechnical Digest - Solid-State Sensors, Actuators, and Microsystems Workshop
PublisherTransducer Research Foundation
Pages383-384
Number of pages2
ISBN (Print)9780964002494
Publication statusPublished - 2012
Event2012 Solid-State Sensors, Actuators and Microsystems Workshop, Hilton Head 2012 - Hilton Head, United States
Duration: Jun 3 2012Jun 7 2012

Other

Other2012 Solid-State Sensors, Actuators and Microsystems Workshop, Hilton Head 2012
CountryUnited States
CityHilton Head
Period6/3/126/7/12

    Fingerprint

ASJC Scopus subject areas

  • Control and Systems Engineering
  • Electrical and Electronic Engineering
  • Hardware and Architecture

Cite this

Wang, R., Huang, S., Li, J., & Chae, J. (2012). Sensitive and selective detection of a cancer biomarker, thyroglobulin, in undiluted human serum using competitive adsorption of proteins and pattern recognition. In Technical Digest - Solid-State Sensors, Actuators, and Microsystems Workshop (pp. 383-384). Transducer Research Foundation.