Abstract

We report a microfluidic-based Surface Plasmon Resonance (SPR) biosensor for rapid, real-time detection of Thyroglobulin (Tg, a sensitive indicator of persistent or recurrent differentiated thyroid cancer with abnormal concentration higher than 3 ng/mL in undiluted human serum, using competitive adsorption of proteins and pattern recognition. The SPR biosensor produces unique patterns from multiple engineered sensing surfaces, and then Linear Discriminant Analysis (LDA) is used to differentiate these patterns. The microfluidic-based biosensor demonstrates the ability to detect 2 ng/mL Tg in undiluted serum with 91.7 % and 90.0 % classification confidence level for its sensitivity and selectivity, respectively.

Original languageEnglish (US)
Title of host publication2012 Solid-State Sensors, Actuators and Microsystems Workshop, Hilton Head 2012
EditorsMehran Mehregany, David J. Monk
PublisherTransducer Research Foundation
Pages383-384
Number of pages2
ISBN (Electronic)9780964002494
DOIs
StatePublished - Jan 1 2012
Event2012 Solid-State Sensors, Actuators and Microsystems Workshop, Hilton Head 2012 - Hilton Head, United States
Duration: Jun 3 2012Jun 7 2012

Publication series

NameTechnical Digest - Solid-State Sensors, Actuators, and Microsystems Workshop

Other

Other2012 Solid-State Sensors, Actuators and Microsystems Workshop, Hilton Head 2012
CountryUnited States
CityHilton Head
Period6/3/126/7/12

ASJC Scopus subject areas

  • Control and Systems Engineering
  • Electrical and Electronic Engineering
  • Hardware and Architecture

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