Abstract
We report a microfluidic-based Surface Plasmon Resonance (SPR) biosensor for rapid, real-time detection of Thyroglobulin (Tg, a sensitive indicator of persistent or recurrent differentiated thyroid cancer with abnormal concentration higher than 3 ng/mL in undiluted human serum, using competitive adsorption of proteins and pattern recognition. The SPR biosensor produces unique patterns from multiple engineered sensing surfaces, and then Linear Discriminant Analysis (LDA) is used to differentiate these patterns. The microfluidic-based biosensor demonstrates the ability to detect 2 ng/mL Tg in undiluted serum with 91.7 % and 90.0 % classification confidence level for its sensitivity and selectivity, respectively.
| Original language | English (US) |
|---|---|
| Title of host publication | Technical Digest - Solid-State Sensors, Actuators, and Microsystems Workshop |
| Publisher | Transducer Research Foundation |
| Pages | 383-384 |
| Number of pages | 2 |
| ISBN (Print) | 9780964002494 |
| Publication status | Published - 2012 |
| Event | 2012 Solid-State Sensors, Actuators and Microsystems Workshop, Hilton Head 2012 - Hilton Head, United States Duration: Jun 3 2012 → Jun 7 2012 |
Other
| Other | 2012 Solid-State Sensors, Actuators and Microsystems Workshop, Hilton Head 2012 |
|---|---|
| Country | United States |
| City | Hilton Head |
| Period | 6/3/12 → 6/7/12 |
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ASJC Scopus subject areas
- Control and Systems Engineering
- Electrical and Electronic Engineering
- Hardware and Architecture
Cite this
Wang, R., Huang, S., Li, J., & Chae, J. (2012). Sensitive and selective detection of a cancer biomarker, thyroglobulin, in undiluted human serum using competitive adsorption of proteins and pattern recognition. In Technical Digest - Solid-State Sensors, Actuators, and Microsystems Workshop (pp. 383-384). Transducer Research Foundation.