@inproceedings{fcdf8fa96ed940e482bba83fc1b7edc7,
title = "Sensitive and selective detection of a cancer biomarker, thyroglobulin, in undiluted human serum using competitive adsorption of proteins and pattern recognition",
abstract = "We report a microfluidic-based Surface Plasmon Resonance (SPR) biosensor for rapid, real-time detection of Thyroglobulin (Tg, a sensitive indicator of persistent or recurrent differentiated thyroid cancer with abnormal concentration higher than 3 ng/mL in undiluted human serum, using competitive adsorption of proteins and pattern recognition. The SPR biosensor produces unique patterns from multiple engineered sensing surfaces, and then Linear Discriminant Analysis (LDA) is used to differentiate these patterns. The microfluidic-based biosensor demonstrates the ability to detect 2 ng/mL Tg in undiluted serum with 91.7 % and 90.0 % classification confidence level for its sensitivity and selectivity, respectively.",
author = "Ran Wang and Shuai Huang and Jing Li and Junseok Chae",
year = "2012",
month = jan,
day = "1",
doi = "10.31438/trf.hh2012.102",
language = "English (US)",
series = "Technical Digest - Solid-State Sensors, Actuators, and Microsystems Workshop",
publisher = "Transducer Research Foundation",
pages = "383--384",
editor = "Mehran Mehregany and Monk, {David J.}",
booktitle = "2012 Solid-State Sensors, Actuators and Microsystems Workshop, Hilton Head 2012",
note = "2012 Solid-State Sensors, Actuators and Microsystems Workshop, Hilton Head 2012 ; Conference date: 03-06-2012 Through 07-06-2012",
}