Self-Healing Hydrogels: The Next Paradigm Shift in Tissue Engineering?

Sepehr Talebian, Mehdi Mehrali, Nayere Taebnia, Cristian Pablo Pennisi, Firoz Babu Kadumudi, Javad Foroughi, Masoud Hasany, Mehdi Nikkhah, Mohsen Akbari, Gorka Orive, Alireza Dolatshahi-Pirouz

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

Given their durability and long-term stability, self-healable hydrogels have, in the past few years, emerged as promising replacements for the many brittle hydrogels currently being used in preclinical or clinical trials. To this end, the incompatibility between hydrogel toughness and rapid self-healing remains unaddressed, and therefore most of the self-healable hydrogels still face serious challenges within the dynamic and mechanically demanding environment of human organs/tissues. Furthermore, depending on the target tissue, the self-healing hydrogels must comply with a wide range of properties including electrical, biological, and mechanical. Notably, the incorporation of nanomaterials into double-network hydrogels is showing great promise as a feasible way to generate self-healable hydrogels with the above-mentioned attributes. Here, the recent progress in the development of multifunctional and self-healable hydrogels for various tissue engineering applications is discussed in detail. Their potential applications within the rapidly expanding areas of bioelectronic hydrogels, cyborganics, and soft robotics are further highlighted.

Original languageEnglish (US)
Article number1801664
JournalAdvanced Science
DOIs
StatePublished - Jan 1 2019
Externally publishedYes

Fingerprint

Hydrogels
tissue engineering
healing
Tissue Engineering
Tissue engineering
incompatibility
shift
toughness
robotics
durability
organs
electrical properties
Tissue
Nanostructures
Hydrogel
Bioelectric potentials
Robotics
Nanostructured materials
Toughness
Electric properties

Keywords

  • cyborganics
  • nanocomposite hydrogels
  • nanomaterials
  • self-healing hydrogels
  • tissue engineering

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Chemical Engineering(all)
  • Materials Science(all)
  • Biochemistry, Genetics and Molecular Biology (miscellaneous)
  • Engineering(all)
  • Physics and Astronomy(all)

Cite this

Talebian, S., Mehrali, M., Taebnia, N., Pennisi, C. P., Kadumudi, F. B., Foroughi, J., ... Dolatshahi-Pirouz, A. (2019). Self-Healing Hydrogels: The Next Paradigm Shift in Tissue Engineering? Advanced Science, [1801664]. https://doi.org/10.1002/advs.201801664

Self-Healing Hydrogels : The Next Paradigm Shift in Tissue Engineering? / Talebian, Sepehr; Mehrali, Mehdi; Taebnia, Nayere; Pennisi, Cristian Pablo; Kadumudi, Firoz Babu; Foroughi, Javad; Hasany, Masoud; Nikkhah, Mehdi; Akbari, Mohsen; Orive, Gorka; Dolatshahi-Pirouz, Alireza.

In: Advanced Science, 01.01.2019.

Research output: Contribution to journalReview article

Talebian, S, Mehrali, M, Taebnia, N, Pennisi, CP, Kadumudi, FB, Foroughi, J, Hasany, M, Nikkhah, M, Akbari, M, Orive, G & Dolatshahi-Pirouz, A 2019, 'Self-Healing Hydrogels: The Next Paradigm Shift in Tissue Engineering?', Advanced Science. https://doi.org/10.1002/advs.201801664
Talebian S, Mehrali M, Taebnia N, Pennisi CP, Kadumudi FB, Foroughi J et al. Self-Healing Hydrogels: The Next Paradigm Shift in Tissue Engineering? Advanced Science. 2019 Jan 1. 1801664. https://doi.org/10.1002/advs.201801664
Talebian, Sepehr ; Mehrali, Mehdi ; Taebnia, Nayere ; Pennisi, Cristian Pablo ; Kadumudi, Firoz Babu ; Foroughi, Javad ; Hasany, Masoud ; Nikkhah, Mehdi ; Akbari, Mohsen ; Orive, Gorka ; Dolatshahi-Pirouz, Alireza. / Self-Healing Hydrogels : The Next Paradigm Shift in Tissue Engineering?. In: Advanced Science. 2019.
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