Self-assembly for the synthesis of functional biomaterials

Nicholas Stephanopoulos, Julia H. Ortony, Samuel I. Stupp

Research output: Contribution to journalArticle

115 Citations (Scopus)

Abstract

The use of self-assembly for the construction of functional biomaterials is a highly promising and exciting area of research, with great potential for the treatment of injury or disease. By using multiple noncovalent interactions, coded into the molecular design of the constituent components, self-assembly allows for the construction of complex, adaptable, and highly tunable materials with potent biological effects. This review describes some of the seminal advances in the use of self-assembly to make novel systems for regenerative medicine and biology. Materials based on peptides, proteins, DNA, or hybrids thereof have found application in the treatment of a wide range of injuries and diseases, and this review outlines the design principles and practical applications of these systems. Most of the examples covered focus on the synthesis of hydrogels for the scaffolding or transplantation of cells, with an emphasis on the biological, mechanical, and structural properties of the resulting materials. In addition, we will discuss the distinct advantages conferred by self-assembly (compared with traditional covalent materials), and present some of the challenges and opportunities for the next generation of self-assembled biomaterials.

Original languageEnglish (US)
Pages (from-to)912-930
Number of pages19
JournalActa Materialia
Volume61
Issue number3
DOIs
StatePublished - Feb 2013
Externally publishedYes

Fingerprint

Biocompatible Materials
Biomaterials
Self assembly
Hydrogels
Peptides
Structural properties
DNA
Proteins
Mechanical properties

Keywords

  • Biomaterials
  • Peptide amphiphiles
  • Peptides
  • Regenerative medicine
  • Self-assembly

ASJC Scopus subject areas

  • Ceramics and Composites
  • Metals and Alloys
  • Polymers and Plastics
  • Electronic, Optical and Magnetic Materials

Cite this

Self-assembly for the synthesis of functional biomaterials. / Stephanopoulos, Nicholas; Ortony, Julia H.; Stupp, Samuel I.

In: Acta Materialia, Vol. 61, No. 3, 02.2013, p. 912-930.

Research output: Contribution to journalArticle

Stephanopoulos, Nicholas ; Ortony, Julia H. ; Stupp, Samuel I. / Self-assembly for the synthesis of functional biomaterials. In: Acta Materialia. 2013 ; Vol. 61, No. 3. pp. 912-930.
@article{4c353c945c224494a55466fb5561b233,
title = "Self-assembly for the synthesis of functional biomaterials",
abstract = "The use of self-assembly for the construction of functional biomaterials is a highly promising and exciting area of research, with great potential for the treatment of injury or disease. By using multiple noncovalent interactions, coded into the molecular design of the constituent components, self-assembly allows for the construction of complex, adaptable, and highly tunable materials with potent biological effects. This review describes some of the seminal advances in the use of self-assembly to make novel systems for regenerative medicine and biology. Materials based on peptides, proteins, DNA, or hybrids thereof have found application in the treatment of a wide range of injuries and diseases, and this review outlines the design principles and practical applications of these systems. Most of the examples covered focus on the synthesis of hydrogels for the scaffolding or transplantation of cells, with an emphasis on the biological, mechanical, and structural properties of the resulting materials. In addition, we will discuss the distinct advantages conferred by self-assembly (compared with traditional covalent materials), and present some of the challenges and opportunities for the next generation of self-assembled biomaterials.",
keywords = "Biomaterials, Peptide amphiphiles, Peptides, Regenerative medicine, Self-assembly",
author = "Nicholas Stephanopoulos and Ortony, {Julia H.} and Stupp, {Samuel I.}",
year = "2013",
month = "2",
doi = "10.1016/j.actamat.2012.10.046",
language = "English (US)",
volume = "61",
pages = "912--930",
journal = "Acta Materialia",
issn = "1359-6454",
publisher = "Elsevier Limited",
number = "3",

}

TY - JOUR

T1 - Self-assembly for the synthesis of functional biomaterials

AU - Stephanopoulos, Nicholas

AU - Ortony, Julia H.

AU - Stupp, Samuel I.

PY - 2013/2

Y1 - 2013/2

N2 - The use of self-assembly for the construction of functional biomaterials is a highly promising and exciting area of research, with great potential for the treatment of injury or disease. By using multiple noncovalent interactions, coded into the molecular design of the constituent components, self-assembly allows for the construction of complex, adaptable, and highly tunable materials with potent biological effects. This review describes some of the seminal advances in the use of self-assembly to make novel systems for regenerative medicine and biology. Materials based on peptides, proteins, DNA, or hybrids thereof have found application in the treatment of a wide range of injuries and diseases, and this review outlines the design principles and practical applications of these systems. Most of the examples covered focus on the synthesis of hydrogels for the scaffolding or transplantation of cells, with an emphasis on the biological, mechanical, and structural properties of the resulting materials. In addition, we will discuss the distinct advantages conferred by self-assembly (compared with traditional covalent materials), and present some of the challenges and opportunities for the next generation of self-assembled biomaterials.

AB - The use of self-assembly for the construction of functional biomaterials is a highly promising and exciting area of research, with great potential for the treatment of injury or disease. By using multiple noncovalent interactions, coded into the molecular design of the constituent components, self-assembly allows for the construction of complex, adaptable, and highly tunable materials with potent biological effects. This review describes some of the seminal advances in the use of self-assembly to make novel systems for regenerative medicine and biology. Materials based on peptides, proteins, DNA, or hybrids thereof have found application in the treatment of a wide range of injuries and diseases, and this review outlines the design principles and practical applications of these systems. Most of the examples covered focus on the synthesis of hydrogels for the scaffolding or transplantation of cells, with an emphasis on the biological, mechanical, and structural properties of the resulting materials. In addition, we will discuss the distinct advantages conferred by self-assembly (compared with traditional covalent materials), and present some of the challenges and opportunities for the next generation of self-assembled biomaterials.

KW - Biomaterials

KW - Peptide amphiphiles

KW - Peptides

KW - Regenerative medicine

KW - Self-assembly

UR - http://www.scopus.com/inward/record.url?scp=84872744450&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84872744450&partnerID=8YFLogxK

U2 - 10.1016/j.actamat.2012.10.046

DO - 10.1016/j.actamat.2012.10.046

M3 - Article

AN - SCOPUS:84872744450

VL - 61

SP - 912

EP - 930

JO - Acta Materialia

JF - Acta Materialia

SN - 1359-6454

IS - 3

ER -