TY - JOUR
T1 - Self-assembly and the origin of the first RNA-like polymers
AU - Bean, Heather D.
AU - Lynn, David G.
AU - Hud, Nicholas V.
PY - 2009/12/20
Y1 - 2009/12/20
N2 - Many hypotheses for the origin of life rely on the existence of an RNA world, a time in which RNA both stored genetic information and performed catalysis, functions that are performed by DNA and proteins, respectively, in extant biology. However, the de novo synthesis of RNA by plausible prebiotic reactions has yet to be demonstrated, leading many researchers to conclude that RNA was preceded by an informational polymer that resembled RNA, but was easier to assemble, i.e., proto-RNA. Still, the synthesis of a proto-RNA is not trivial, requiring the selection of a subset of building blocks out of a diverse prebiotic chemical inventory, and their correct coupling into a polymer. In this chapter we focus on the difficulty of selection and coupling in the de novo synthesis of RNA-like polymers and provide support for the utility of molecular midwives and reversible bonding along a template in overcoming these challenges.
AB - Many hypotheses for the origin of life rely on the existence of an RNA world, a time in which RNA both stored genetic information and performed catalysis, functions that are performed by DNA and proteins, respectively, in extant biology. However, the de novo synthesis of RNA by plausible prebiotic reactions has yet to be demonstrated, leading many researchers to conclude that RNA was preceded by an informational polymer that resembled RNA, but was easier to assemble, i.e., proto-RNA. Still, the synthesis of a proto-RNA is not trivial, requiring the selection of a subset of building blocks out of a diverse prebiotic chemical inventory, and their correct coupling into a polymer. In this chapter we focus on the difficulty of selection and coupling in the de novo synthesis of RNA-like polymers and provide support for the utility of molecular midwives and reversible bonding along a template in overcoming these challenges.
UR - http://www.scopus.com/inward/record.url?scp=84866500301&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84866500301&partnerID=8YFLogxK
U2 - 10.1021/bk-2009-1025.ch006
DO - 10.1021/bk-2009-1025.ch006
M3 - Article
AN - SCOPUS:84866500301
SN - 0097-6156
VL - 1025
SP - 109
EP - 132
JO - ACS Symposium Series
JF - ACS Symposium Series
ER -