Selective synaptic plasticity within the cerebellar cortex following complex motor skill learning

Jeffrey Kleim, Rodney A. Swain, Kim A. Armstrong, Ruth M A Napper, Theresa A. Jones, William T. Greenough

Research output: Contribution to journalArticle

154 Citations (Scopus)

Abstract

Complex motor skill learning, but not mere motor activity, leads to an increase in synapse number within the cerebellar cortex. The present experiment used quantitative electron microscopy to determine which synapse types were altered in number. Adult female rats were allocated to either an acrobatic condition (AC), a voluntary exercise condition (VX), or an inactive condition (IC). AC animals were trained to traverse an elevated obstacle course requiring substantial motor coordination to complete. VX animals were housed with unlimited access to running wheels and IC animals received no motor training but were handled briefly each day. Results showed the AC animals to have significantly more parallel fiber to Purkinje cell synapses than both the VX and IC animals. No other synapse type was significantly altered. Thus, the learning-dependent increase in synapse number observed within the cerebellar cortex is accomplished primarily through the addition of parallel fiber synapses.

Original languageEnglish (US)
Pages (from-to)274-289
Number of pages16
JournalNeurobiology of Learning and Memory
Volume69
Issue number3
DOIs
StatePublished - May 1998
Externally publishedYes

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Cerebellar Cortex
Neuronal Plasticity
Motor Skills
Synapses
Learning
Purkinje Cells
Running
Electron Microscopy
Motor Activity
VX

ASJC Scopus subject areas

  • Behavioral Neuroscience
  • Cognitive Neuroscience
  • Experimental and Cognitive Psychology

Cite this

Selective synaptic plasticity within the cerebellar cortex following complex motor skill learning. / Kleim, Jeffrey; Swain, Rodney A.; Armstrong, Kim A.; Napper, Ruth M A; Jones, Theresa A.; Greenough, William T.

In: Neurobiology of Learning and Memory, Vol. 69, No. 3, 05.1998, p. 274-289.

Research output: Contribution to journalArticle

Kleim, Jeffrey ; Swain, Rodney A. ; Armstrong, Kim A. ; Napper, Ruth M A ; Jones, Theresa A. ; Greenough, William T. / Selective synaptic plasticity within the cerebellar cortex following complex motor skill learning. In: Neurobiology of Learning and Memory. 1998 ; Vol. 69, No. 3. pp. 274-289.
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