Selective instability: Maternal effort and the evolution of gene activation and deactivation rates

Carlo C. Maley, Stephen J. Tapscott

Research output: Contribution to journalLetter

Abstract

We previously used simulations of gene expression to demonstrate that rapid activation and deactivation rates stabilized outcomes in stochastic systems. We hypothesized that transient single allele inactivation of an autosomal gene during gametogenesis or very early embryogenesis could have a selective advantage if it permits the functional sampling of each allele and precludes committing maternal effort to an embryo with a deleterious mutation. To test this hypothesis, we simulated the evolution of gene expression activation and deactivation rates and imposed two different selective pressures on the populations: (a) late selection against individuals that cannot maintain a threshold level of gene product that occurs after the investment of maternal effort (i.e., after birth); or (b) early selection: in addition to late selection, maintenance of the gene product above a threshold level was necessary for early development prior to commitment of maternal effort. We found that the opportunity to save reproductive effort from early selection caused the evolution of higher deactivation rates and lower activation rates than in the late selection condition. Thus, we predict that in the special case where early selection can save maternal investment in non-viable offspring, gene expression activation rates and deactivation rates might be selected to permit sampling of the product from each allele.

Original languageEnglish (US)
Pages (from-to)317-326
Number of pages10
JournalArtificial Life
Volume9
Issue number3
DOIs
StatePublished - Jun 1 2003
Externally publishedYes

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Keywords

  • Evolution
  • Gene expression
  • Haploinsufficiency
  • Instability
  • Maternal effort

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Artificial Intelligence

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