Selective inactivation of Human Immunodeficiency Virus with an ultrashort pulsed laser

Kong-Thon Tsen, Shaw Wei D Tsen, Chien Fu Hung, T. C. Wu, Karen Kibler, Bertram Jacobs, Juliann G. Kiang

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Recently, femtosecond laser technology has been shown to be effective in the inactivation of non-pathogenic viruses. In this paper, we demonstrate for the first time that infectious numbers of pathogenic viruses such as Human Immunodeficiency Virus (HIV) can be reduced by irradiation with subpicosecond near infrared laser pulses at a moderate laser power density. By comparing the threshold laser power density for the inactivation of HIV with those of human red blood cells and mouse dendritic cells, we conclude that it is plausible to use the ultrashort pulsed laser to selectively inactivate blood-borne pathogens such as HIV while leaving the sensitive materials like human red blood cells unharmed. This finding has important implications in the development of a new laser technology for disinfection of viral pathogens in blood products and in the clinic.

Original languageEnglish (US)
Title of host publicationProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume7175
DOIs
StatePublished - 2009
EventOptical Interactions with Tissue and Cells XX - San Jose, CA, United States
Duration: Jan 26 2009Jan 28 2009

Other

OtherOptical Interactions with Tissue and Cells XX
CountryUnited States
CitySan Jose, CA
Period1/26/091/28/09

Fingerprint

ultrashort pulsed lasers
human immunodeficiency virus
Pulsed lasers
Viruses
deactivation
Lasers
HIV
Blood
pathogens
erythrocytes
viruses
blood
lasers
radiant flux density
Pathogens
Cells
Erythrocytes
Blood-Borne Pathogens
infrared lasers
Infrared lasers

Keywords

  • Human Immunodeficiency Virus
  • Pathogen inactivation
  • Ultrashort pulsed laser
  • Viral load reduction

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

Cite this

Tsen, K-T., Tsen, S. W. D., Hung, C. F., Wu, T. C., Kibler, K., Jacobs, B., & Kiang, J. G. (2009). Selective inactivation of Human Immunodeficiency Virus with an ultrashort pulsed laser. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE (Vol. 7175). [717510] https://doi.org/10.1117/12.808532

Selective inactivation of Human Immunodeficiency Virus with an ultrashort pulsed laser. / Tsen, Kong-Thon; Tsen, Shaw Wei D; Hung, Chien Fu; Wu, T. C.; Kibler, Karen; Jacobs, Bertram; Kiang, Juliann G.

Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 7175 2009. 717510.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Tsen, K-T, Tsen, SWD, Hung, CF, Wu, TC, Kibler, K, Jacobs, B & Kiang, JG 2009, Selective inactivation of Human Immunodeficiency Virus with an ultrashort pulsed laser. in Progress in Biomedical Optics and Imaging - Proceedings of SPIE. vol. 7175, 717510, Optical Interactions with Tissue and Cells XX, San Jose, CA, United States, 1/26/09. https://doi.org/10.1117/12.808532
Tsen K-T, Tsen SWD, Hung CF, Wu TC, Kibler K, Jacobs B et al. Selective inactivation of Human Immunodeficiency Virus with an ultrashort pulsed laser. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 7175. 2009. 717510 https://doi.org/10.1117/12.808532
Tsen, Kong-Thon ; Tsen, Shaw Wei D ; Hung, Chien Fu ; Wu, T. C. ; Kibler, Karen ; Jacobs, Bertram ; Kiang, Juliann G. / Selective inactivation of Human Immunodeficiency Virus with an ultrashort pulsed laser. Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 7175 2009.
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