Segregation of the yeast plasmid: Similarities and contrasts with bacterial plasmid partitioning

Makkuni Jayaram, Shwetal Mehta, Dina Uzri, Soundarapandian Velmurugan

Research output: Contribution to journalReview articlepeer-review

8 Scopus citations

Abstract

The high copy yeast plasmid 2μm circle, like the well-studied low copy bacterial plasmids, utilizes two partitioning proteins and a cis-acting 'centromere'-like sequence for its stable propagation. Functionally, though, the protein and DNA constituents of the two partitioning systems are quite distinct. Key events in the yeast and bacterial segregation pathways are plasmid organization, localization, replication, 'counting' of replicated molecules and their distribution to daughter cells. We suggest that the two systems facilitate these common logistical steps by adapting to the physical, biochemical, and mechanical contexts in which the host chromosomes segregate.

Original languageEnglish (US)
Pages (from-to)162-178
Number of pages17
JournalPlasmid
Volume51
Issue number3
DOIs
StatePublished - May 2004
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Biology

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