TY - JOUR
T1 - Segregation of the yeast plasmid
T2 - Similarities and contrasts with bacterial plasmid partitioning
AU - Jayaram, Makkuni
AU - Mehta, Shwetal
AU - Uzri, Dina
AU - Velmurugan, Soundarapandian
N1 - Funding Information:
Work in the Jayaram laboratory on yeast plasmid partitioning was initiated with funds provided by the Tobacco Research Foundation. The current projects are supported by a grant from the National Institutes of Health with partial support provided by the Robert F. Welch Foundation.
PY - 2004/5
Y1 - 2004/5
N2 - The high copy yeast plasmid 2μm circle, like the well-studied low copy bacterial plasmids, utilizes two partitioning proteins and a cis-acting 'centromere'-like sequence for its stable propagation. Functionally, though, the protein and DNA constituents of the two partitioning systems are quite distinct. Key events in the yeast and bacterial segregation pathways are plasmid organization, localization, replication, 'counting' of replicated molecules and their distribution to daughter cells. We suggest that the two systems facilitate these common logistical steps by adapting to the physical, biochemical, and mechanical contexts in which the host chromosomes segregate.
AB - The high copy yeast plasmid 2μm circle, like the well-studied low copy bacterial plasmids, utilizes two partitioning proteins and a cis-acting 'centromere'-like sequence for its stable propagation. Functionally, though, the protein and DNA constituents of the two partitioning systems are quite distinct. Key events in the yeast and bacterial segregation pathways are plasmid organization, localization, replication, 'counting' of replicated molecules and their distribution to daughter cells. We suggest that the two systems facilitate these common logistical steps by adapting to the physical, biochemical, and mechanical contexts in which the host chromosomes segregate.
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U2 - 10.1016/j.plasmid.2004.02.005
DO - 10.1016/j.plasmid.2004.02.005
M3 - Review article
C2 - 15109823
AN - SCOPUS:1942519229
SN - 0147-619X
VL - 51
SP - 162
EP - 178
JO - Plasmid
JF - Plasmid
IS - 3
ER -