Seeded growth of adaptive tiles on DNA origami

Yan Liu, Jin Cheng, Yuqi Wang, Bin Ji, Linlin Tang, Kexuan Zou, Yujie Xie, Daxiang Cui, Yonggang Ke, Jie Song

Research output: Contribution to journalArticlepeer-review

Abstract

Structural DNA nanotechnology has been applied to construct complex static and dynamic DNA structures. Seeded growth, intended to regulate the crucial nucleation step, has been used to control the assembly of DNA tiles. However, most of the seeded growth strategies were applied to fixed DNA tiles, whereas the seeded growth on dynamic DNA tiles remains unreported. Here, we propose a seeded growth strategy in which dynamic tiles adaptively change their shapes to match the architecture of a DNA origami seed. Furthermore, when more adaptive DNA tiles assemble on a reconfigurable DNA origami domino array (DODA) seed, the conformation of DODA seeds is reversibly affected by the spontaneous reconfiguration of adaptive tiles. The adaptive seeded growth provides a mechanism for the construction of complex DNA nanomachines and may offer a general and adaptable method for the advancement of responsive materials, with active, autonomous, and adaptive spatiotemporal control properties.

Original languageEnglish (US)
Article number101040
JournalCell Reports Physical Science
Volume3
Issue number9
DOIs
StatePublished - Sep 21 2022
Externally publishedYes

Keywords

  • adaptive seeded growth
  • DNA nanotechnology
  • dynamic DNA tile
  • molecular tug-of-war
  • reconfigurable DNA origami seed

ASJC Scopus subject areas

  • Chemistry(all)
  • Materials Science(all)
  • Engineering(all)
  • Energy(all)
  • Physics and Astronomy(all)

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