TY - JOUR
T1 - Seeded growth of adaptive tiles on DNA origami
AU - Liu, Yan
AU - Cheng, Jin
AU - Wang, Yuqi
AU - Ji, Bin
AU - Tang, Linlin
AU - Zou, Kexuan
AU - Xie, Yujie
AU - Cui, Daxiang
AU - Ke, Yonggang
AU - Song, Jie
N1 - Funding Information:
The authors are grateful for the financial support from the National Natural Science Foundation of China (nos. 81822024 and 22161132008), the Natural Science Foundation of Shanghai, China (nos. 19520714100 and 19ZR1475800), the Project of Shanghai Jiao Tong University (nos. 2019QYA03 and YG2017ZD07), and the startup funding from Institute of Basic Medicine and Cancer (IBMC), Chinese Academy of Sciences (2020QD04). We also acknowledge the Shared Instrumentation Facility at the Institute of Basic Medicine and Cancer (IBMC), Chinese Academy of Sciences and Zhiyuan Innovative Research Center, SJTU. Conceptualization, J.S. and Y.K.; methodology, Y.L.; investigation, Y.L.; writing – original draft, Y.L.; writing – review & editing, J.S. Y.K. Y.L. J.C. Y.W. and Y.X.; visualization, Y.L. J.S. Y.K. K.Z. L.T. Y.X. and D.C.; funding acquisition, J.S.; supervision, J.S. and Y.K. The authors declare no competing interests.
Funding Information:
The authors are grateful for the financial support from the National Natural Science Foundation of China (nos. 81822024 and 22161132008 ), the Natural Science Foundation of Shanghai , China (nos. 19520714100 and 19ZR1475800 ), the Project of Shanghai Jiao Tong University (nos. 2019QYA03 and YG2017ZD07 ), and the startup funding from Institute of Basic Medicine and Cancer (IBMC), Chinese Academy of Sciences ( 2020QD04 ). We also acknowledge the Shared Instrumentation Facility at the Institute of Basic Medicine and Cancer (IBMC), Chinese Academy of Sciences and Zhiyuan Innovative Research Center, SJTU.
Publisher Copyright:
© 2022 The Author(s)
PY - 2022/9/21
Y1 - 2022/9/21
N2 - Structural DNA nanotechnology has been applied to construct complex static and dynamic DNA structures. Seeded growth, intended to regulate the crucial nucleation step, has been used to control the assembly of DNA tiles. However, most of the seeded growth strategies were applied to fixed DNA tiles, whereas the seeded growth on dynamic DNA tiles remains unreported. Here, we propose a seeded growth strategy in which dynamic tiles adaptively change their shapes to match the architecture of a DNA origami seed. Furthermore, when more adaptive DNA tiles assemble on a reconfigurable DNA origami domino array (DODA) seed, the conformation of DODA seeds is reversibly affected by the spontaneous reconfiguration of adaptive tiles. The adaptive seeded growth provides a mechanism for the construction of complex DNA nanomachines and may offer a general and adaptable method for the advancement of responsive materials, with active, autonomous, and adaptive spatiotemporal control properties.
AB - Structural DNA nanotechnology has been applied to construct complex static and dynamic DNA structures. Seeded growth, intended to regulate the crucial nucleation step, has been used to control the assembly of DNA tiles. However, most of the seeded growth strategies were applied to fixed DNA tiles, whereas the seeded growth on dynamic DNA tiles remains unreported. Here, we propose a seeded growth strategy in which dynamic tiles adaptively change their shapes to match the architecture of a DNA origami seed. Furthermore, when more adaptive DNA tiles assemble on a reconfigurable DNA origami domino array (DODA) seed, the conformation of DODA seeds is reversibly affected by the spontaneous reconfiguration of adaptive tiles. The adaptive seeded growth provides a mechanism for the construction of complex DNA nanomachines and may offer a general and adaptable method for the advancement of responsive materials, with active, autonomous, and adaptive spatiotemporal control properties.
KW - adaptive seeded growth
KW - DNA nanotechnology
KW - dynamic DNA tile
KW - molecular tug-of-war
KW - reconfigurable DNA origami seed
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U2 - 10.1016/j.xcrp.2022.101040
DO - 10.1016/j.xcrp.2022.101040
M3 - Article
AN - SCOPUS:85138203440
VL - 3
JO - Cell Reports Physical Science
JF - Cell Reports Physical Science
SN - 2666-3864
IS - 9
M1 - 101040
ER -