Sedimentation studies on human amylin fail to detect low-molecular-weight oligomers

Sara M. Vaiana, Rodolfo Ghirlando, Wai Ming Yau, William A. Eaton, James Hofrichter

Research output: Contribution to journalArticle

34 Scopus citations

Abstract

Sedimentation velocity experiments show that only monomers coexist with amyloid fibrils of human islet amyloidpolypeptide. No oligomers containing >100 monomers could be detected, suggesting that the putative toxic oligomers are much larger than those found for the Alzheimer's peptide, Aβ(1-42).

Original languageEnglish (US)
Pages (from-to)L45-L47
JournalBiophysical journal
Volume94
Issue number7
DOIs
StatePublished - Apr 2008

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ASJC Scopus subject areas

  • Biophysics

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