Sedimentation studies on human amylin fail to detect low-molecular-weight oligomers

Sara M. Vaiana, Rodolfo Ghirlando, Wai Ming Yau, William A. Eaton, James Hofrichter

Research output: Contribution to journalArticle

34 Scopus citations


Sedimentation velocity experiments show that only monomers coexist with amyloid fibrils of human islet amyloidpolypeptide. No oligomers containing >100 monomers could be detected, suggesting that the putative toxic oligomers are much larger than those found for the Alzheimer's peptide, Aβ(1-42).

Original languageEnglish (US)
Pages (from-to)L45-L47
JournalBiophysical journal
Issue number7
StatePublished - Apr 2008


ASJC Scopus subject areas

  • Biophysics

Cite this