Sedentary behaviors and biomarkers among breast cancer survivors

Sheri J. Hartman, Catherine R. Marinac, Lisa Cadmus-Bertram, Jacqueline Kerr, Loki Natarajan, Suneeta Godbole, Ruth E. Patterson, Brittany Morey, Dorothy D. Sears

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background: Sedentary behavior is associated with increased risk of poor outcomes in breast cancer survivors, but underlying mechanisms are not well understood. This pilot study explored associations between different aspects of sedentary behaviors (sitting, prolonged sitting, sit-to-stand transitions, and standing) and breast cancer risk-related biomarkers in breast cancer survivors (n = 30). Methods: Sedentary behavior variables were objectively measured with thigh-worn activPALs. Breast cancer risk-related biomarkers assessed were C-reactive protein (CRP), insulin, and homeostatic model assessment of insulin resistance (HOMA-IR) and were measured in fasting plasma samples. Linear regression models were used to investigate associations between sedentary behavior variables and biomarkers (log CRP, insulin, and HOMA-IR). Results: Sit-to-stand transitions were significantly associated with insulin resistance biomarkers (P < .05). Specifically, each 10 additional sit-to-stand transitions per day was associated with a lower fasting insulin concentration (β = -5.52; 95% CI, -9.79 to -1.24) and a lower HOMA-IR value (β = -0.22; 95% CI, -0.42 to -0.03). Sit-to-stand transitions were not significantly associated with CRP concentration (P = .08). Total sitting time, long sitting bouts, and standing time were not significantly associated with CRP, insulin, or HOMA-IR (P > .05). Conclusions: Sit-to-stand transitions may be an intervention target for reducing insulin resistance in breast cancer survivors, which may have favorable downstream effects on cancer prognosis.

Original languageEnglish (US)
Pages (from-to)1-6
Number of pages6
JournalJournal of Physical Activity and Health
Volume15
Issue number1
DOIs
StatePublished - Jan 2018
Externally publishedYes

Fingerprint

Biomarkers
Insulin Resistance
Breast Neoplasms
C-Reactive Protein
Linear Models
Insulin
Thigh
Fasting
Neoplasms

Keywords

  • Inflammation
  • Insulin resistance
  • Sit-to-stand transitions
  • Sitting

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine

Cite this

Hartman, S. J., Marinac, C. R., Cadmus-Bertram, L., Kerr, J., Natarajan, L., Godbole, S., ... Sears, D. D. (2018). Sedentary behaviors and biomarkers among breast cancer survivors. Journal of Physical Activity and Health, 15(1), 1-6. https://doi.org/10.1123/jpah.2017-0045

Sedentary behaviors and biomarkers among breast cancer survivors. / Hartman, Sheri J.; Marinac, Catherine R.; Cadmus-Bertram, Lisa; Kerr, Jacqueline; Natarajan, Loki; Godbole, Suneeta; Patterson, Ruth E.; Morey, Brittany; Sears, Dorothy D.

In: Journal of Physical Activity and Health, Vol. 15, No. 1, 01.2018, p. 1-6.

Research output: Contribution to journalArticle

Hartman, SJ, Marinac, CR, Cadmus-Bertram, L, Kerr, J, Natarajan, L, Godbole, S, Patterson, RE, Morey, B & Sears, DD 2018, 'Sedentary behaviors and biomarkers among breast cancer survivors', Journal of Physical Activity and Health, vol. 15, no. 1, pp. 1-6. https://doi.org/10.1123/jpah.2017-0045
Hartman SJ, Marinac CR, Cadmus-Bertram L, Kerr J, Natarajan L, Godbole S et al. Sedentary behaviors and biomarkers among breast cancer survivors. Journal of Physical Activity and Health. 2018 Jan;15(1):1-6. https://doi.org/10.1123/jpah.2017-0045
Hartman, Sheri J. ; Marinac, Catherine R. ; Cadmus-Bertram, Lisa ; Kerr, Jacqueline ; Natarajan, Loki ; Godbole, Suneeta ; Patterson, Ruth E. ; Morey, Brittany ; Sears, Dorothy D. / Sedentary behaviors and biomarkers among breast cancer survivors. In: Journal of Physical Activity and Health. 2018 ; Vol. 15, No. 1. pp. 1-6.
@article{714529671ccc4c4e852d481de600905e,
title = "Sedentary behaviors and biomarkers among breast cancer survivors",
abstract = "Background: Sedentary behavior is associated with increased risk of poor outcomes in breast cancer survivors, but underlying mechanisms are not well understood. This pilot study explored associations between different aspects of sedentary behaviors (sitting, prolonged sitting, sit-to-stand transitions, and standing) and breast cancer risk-related biomarkers in breast cancer survivors (n = 30). Methods: Sedentary behavior variables were objectively measured with thigh-worn activPALs. Breast cancer risk-related biomarkers assessed were C-reactive protein (CRP), insulin, and homeostatic model assessment of insulin resistance (HOMA-IR) and were measured in fasting plasma samples. Linear regression models were used to investigate associations between sedentary behavior variables and biomarkers (log CRP, insulin, and HOMA-IR). Results: Sit-to-stand transitions were significantly associated with insulin resistance biomarkers (P < .05). Specifically, each 10 additional sit-to-stand transitions per day was associated with a lower fasting insulin concentration (β = -5.52; 95{\%} CI, -9.79 to -1.24) and a lower HOMA-IR value (β = -0.22; 95{\%} CI, -0.42 to -0.03). Sit-to-stand transitions were not significantly associated with CRP concentration (P = .08). Total sitting time, long sitting bouts, and standing time were not significantly associated with CRP, insulin, or HOMA-IR (P > .05). Conclusions: Sit-to-stand transitions may be an intervention target for reducing insulin resistance in breast cancer survivors, which may have favorable downstream effects on cancer prognosis.",
keywords = "Inflammation, Insulin resistance, Sit-to-stand transitions, Sitting",
author = "Hartman, {Sheri J.} and Marinac, {Catherine R.} and Lisa Cadmus-Bertram and Jacqueline Kerr and Loki Natarajan and Suneeta Godbole and Patterson, {Ruth E.} and Brittany Morey and Sears, {Dorothy D.}",
year = "2018",
month = "1",
doi = "10.1123/jpah.2017-0045",
language = "English (US)",
volume = "15",
pages = "1--6",
journal = "Journal of Physical Activity and Health",
issn = "1543-3080",
publisher = "Human Kinetics Publishers Inc.",
number = "1",

}

TY - JOUR

T1 - Sedentary behaviors and biomarkers among breast cancer survivors

AU - Hartman, Sheri J.

AU - Marinac, Catherine R.

AU - Cadmus-Bertram, Lisa

AU - Kerr, Jacqueline

AU - Natarajan, Loki

AU - Godbole, Suneeta

AU - Patterson, Ruth E.

AU - Morey, Brittany

AU - Sears, Dorothy D.

PY - 2018/1

Y1 - 2018/1

N2 - Background: Sedentary behavior is associated with increased risk of poor outcomes in breast cancer survivors, but underlying mechanisms are not well understood. This pilot study explored associations between different aspects of sedentary behaviors (sitting, prolonged sitting, sit-to-stand transitions, and standing) and breast cancer risk-related biomarkers in breast cancer survivors (n = 30). Methods: Sedentary behavior variables were objectively measured with thigh-worn activPALs. Breast cancer risk-related biomarkers assessed were C-reactive protein (CRP), insulin, and homeostatic model assessment of insulin resistance (HOMA-IR) and were measured in fasting plasma samples. Linear regression models were used to investigate associations between sedentary behavior variables and biomarkers (log CRP, insulin, and HOMA-IR). Results: Sit-to-stand transitions were significantly associated with insulin resistance biomarkers (P < .05). Specifically, each 10 additional sit-to-stand transitions per day was associated with a lower fasting insulin concentration (β = -5.52; 95% CI, -9.79 to -1.24) and a lower HOMA-IR value (β = -0.22; 95% CI, -0.42 to -0.03). Sit-to-stand transitions were not significantly associated with CRP concentration (P = .08). Total sitting time, long sitting bouts, and standing time were not significantly associated with CRP, insulin, or HOMA-IR (P > .05). Conclusions: Sit-to-stand transitions may be an intervention target for reducing insulin resistance in breast cancer survivors, which may have favorable downstream effects on cancer prognosis.

AB - Background: Sedentary behavior is associated with increased risk of poor outcomes in breast cancer survivors, but underlying mechanisms are not well understood. This pilot study explored associations between different aspects of sedentary behaviors (sitting, prolonged sitting, sit-to-stand transitions, and standing) and breast cancer risk-related biomarkers in breast cancer survivors (n = 30). Methods: Sedentary behavior variables were objectively measured with thigh-worn activPALs. Breast cancer risk-related biomarkers assessed were C-reactive protein (CRP), insulin, and homeostatic model assessment of insulin resistance (HOMA-IR) and were measured in fasting plasma samples. Linear regression models were used to investigate associations between sedentary behavior variables and biomarkers (log CRP, insulin, and HOMA-IR). Results: Sit-to-stand transitions were significantly associated with insulin resistance biomarkers (P < .05). Specifically, each 10 additional sit-to-stand transitions per day was associated with a lower fasting insulin concentration (β = -5.52; 95% CI, -9.79 to -1.24) and a lower HOMA-IR value (β = -0.22; 95% CI, -0.42 to -0.03). Sit-to-stand transitions were not significantly associated with CRP concentration (P = .08). Total sitting time, long sitting bouts, and standing time were not significantly associated with CRP, insulin, or HOMA-IR (P > .05). Conclusions: Sit-to-stand transitions may be an intervention target for reducing insulin resistance in breast cancer survivors, which may have favorable downstream effects on cancer prognosis.

KW - Inflammation

KW - Insulin resistance

KW - Sit-to-stand transitions

KW - Sitting

UR - http://www.scopus.com/inward/record.url?scp=85036525226&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85036525226&partnerID=8YFLogxK

U2 - 10.1123/jpah.2017-0045

DO - 10.1123/jpah.2017-0045

M3 - Article

C2 - 28682735

AN - SCOPUS:85036525226

VL - 15

SP - 1

EP - 6

JO - Journal of Physical Activity and Health

JF - Journal of Physical Activity and Health

SN - 1543-3080

IS - 1

ER -