Secretion of virulence determinants by the general secretory pathway in Gram-negative pathogens: An evolving story

Christos Stathopoulos; David R. Hendrixson; David G. Thanassi; Scott J. Hultgren; Joseph W. St. Geme; Roy Curtiss

doi:10.1016/S1286-4579(00)01260-0

Secretion of virulence determinants by the general secretory pathway in Gram-negative pathogens: An evolving story

Christos Stathopoulos, David R. Hendrixson, David G. Thanassi, Scott J. Hultgren, Joseph W. St. Geme, Roy Curtiss

Research output: Contribution to journal › Review article › peer-review

127 Scopus citations

Abstract

Secretion of proteins by the general secretory pathway (GSP) is a two- step process requiring the Sec translocase in the inner membrane and a separate substrate-specific secretion apparatus for translocation across the outer membrane. Gram-negative bacteria with pathogenic potential use the GSP to deliver virulence factors into the extracellular environment for interaction with the host. Well-studied examples of virulence determinants using the GSP for secretion include extracellular toxins, pili, curli, autotransporters, and crystaline S-layers. This article reviews our current understanding of the GSP and discusses examples of terminal branches of the GSP which are utilized by factors implicated in bacterial virulence. (C) 2000 Editions scientifiques et medicales Elsevier SAS.

Original language	English (US)
Pages (from-to)	1061-1072
Number of pages	12
Journal	Microbes and Infection
Volume	2
Issue number	9
DOIs	https://doi.org/10.1016/S1286-4579(00)01260-0
State	Published - 2000
Externally published	Yes

Keywords

Autotransporters
Curli
Elsevier SAS Gram-negative bacteria
General secretory pathway
Pili
Pullulanase
S-layers
Sec translocase
Toxins

ASJC Scopus subject areas

Microbiology
Immunology
Infectious Diseases

Access to Document

10.1016/S1286-4579(00)01260-0

Cite this

@article{4582410fdd16441f9fcf455517f3a9f5,

title = "Secretion of virulence determinants by the general secretory pathway in Gram-negative pathogens: An evolving story",

abstract = "Secretion of proteins by the general secretory pathway (GSP) is a two- step process requiring the Sec translocase in the inner membrane and a separate substrate-specific secretion apparatus for translocation across the outer membrane. Gram-negative bacteria with pathogenic potential use the GSP to deliver virulence factors into the extracellular environment for interaction with the host. Well-studied examples of virulence determinants using the GSP for secretion include extracellular toxins, pili, curli, autotransporters, and crystaline S-layers. This article reviews our current understanding of the GSP and discusses examples of terminal branches of the GSP which are utilized by factors implicated in bacterial virulence. (C) 2000 Editions scientifiques et medicales Elsevier SAS.",

keywords = "Autotransporters, Curli, Elsevier SAS Gram-negative bacteria, General secretory pathway, Pili, Pullulanase, S-layers, Sec translocase, Toxins",

author = "Christos Stathopoulos and Hendrixson, {David R.} and Thanassi, {David G.} and Hultgren, {Scott J.} and {St. Geme}, {Joseph W.} and Roy Curtiss",

note = "Funding Information: We would like to thank Charles M. Dozois, France Daigle, Kone Kaniga, Barbara N. Kunkel, and the anonymous reviewer for providing many helpful comments on the manuscript. Work in the RC laboratory is supported by grants provided from NIH (R01 AI24533) and USDA (94–37204–1091). Work in the SJH laboratory is supported by NIH R01 AI29549 and NIH R01 DK51406 grants. Work in the JWS laboratory is supported by NIH R01 AI/DC44167, NIH R01 DC02873, an American Heart Association Established Investigator Award, and a March of Dimes research grant. CS was recipient of an NIH Research Service Award Traineeship (AI07172–20).",

year = "2000",

doi = "10.1016/S1286-4579(00)01260-0",

language = "English (US)",

volume = "2",

pages = "1061--1072",

journal = "Microbes and Infection",

issn = "1286-4579",

publisher = "Elsevier Masson SAS",

number = "9",

}

TY - JOUR

T1 - Secretion of virulence determinants by the general secretory pathway in Gram-negative pathogens

T2 - An evolving story

AU - Stathopoulos, Christos

AU - Hendrixson, David R.

AU - Thanassi, David G.

AU - Hultgren, Scott J.

AU - St. Geme, Joseph W.

AU - Curtiss, Roy

N1 - Funding Information: We would like to thank Charles M. Dozois, France Daigle, Kone Kaniga, Barbara N. Kunkel, and the anonymous reviewer for providing many helpful comments on the manuscript. Work in the RC laboratory is supported by grants provided from NIH (R01 AI24533) and USDA (94–37204–1091). Work in the SJH laboratory is supported by NIH R01 AI29549 and NIH R01 DK51406 grants. Work in the JWS laboratory is supported by NIH R01 AI/DC44167, NIH R01 DC02873, an American Heart Association Established Investigator Award, and a March of Dimes research grant. CS was recipient of an NIH Research Service Award Traineeship (AI07172–20).

PY - 2000

Y1 - 2000

N2 - Secretion of proteins by the general secretory pathway (GSP) is a two- step process requiring the Sec translocase in the inner membrane and a separate substrate-specific secretion apparatus for translocation across the outer membrane. Gram-negative bacteria with pathogenic potential use the GSP to deliver virulence factors into the extracellular environment for interaction with the host. Well-studied examples of virulence determinants using the GSP for secretion include extracellular toxins, pili, curli, autotransporters, and crystaline S-layers. This article reviews our current understanding of the GSP and discusses examples of terminal branches of the GSP which are utilized by factors implicated in bacterial virulence. (C) 2000 Editions scientifiques et medicales Elsevier SAS.

AB - Secretion of proteins by the general secretory pathway (GSP) is a two- step process requiring the Sec translocase in the inner membrane and a separate substrate-specific secretion apparatus for translocation across the outer membrane. Gram-negative bacteria with pathogenic potential use the GSP to deliver virulence factors into the extracellular environment for interaction with the host. Well-studied examples of virulence determinants using the GSP for secretion include extracellular toxins, pili, curli, autotransporters, and crystaline S-layers. This article reviews our current understanding of the GSP and discusses examples of terminal branches of the GSP which are utilized by factors implicated in bacterial virulence. (C) 2000 Editions scientifiques et medicales Elsevier SAS.

KW - Autotransporters

KW - Curli

KW - Elsevier SAS Gram-negative bacteria

KW - General secretory pathway

KW - Pili

KW - Pullulanase

KW - S-layers

KW - Sec translocase

KW - Toxins

UR - http://www.scopus.com/inward/record.url?scp=0033842544&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033842544&partnerID=8YFLogxK

U2 - 10.1016/S1286-4579(00)01260-0

DO - 10.1016/S1286-4579(00)01260-0

M3 - Review article

C2 - 10967286

AN - SCOPUS:0033842544

SN - 1286-4579

VL - 2

SP - 1061

EP - 1072

JO - Microbes and Infection

JF - Microbes and Infection

IS - 9

ER -

Secretion of virulence determinants by the general secretory pathway in Gram-negative pathogens: An evolving story

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this