Secreted poxvirus chemokine binding proteins

Alshad S. Lalani, Douglas McFadden

Research output: Contribution to journalReview article

49 Citations (Scopus)

Abstract

Poxviruses encode a variety of immunomodulatory proteins that subvert the cytokine networks of infected hosts. Myxoma virus, a poxvirus pathogen of rabbits, expresses two distinct 35- to 40-kDa secreted glycoproteins that bind a broad spectrum of chemokines. The first of these, designated M-T7, is encoded by the T7 gene and is the first example of what is here referred to as type-I chemokine binding protein (CBP-I). M-T7 was initially discovered as a secreted vital homologue of cellular interferon-γ receptor but binding studies indicate that purified M-T7 protein also interacts with members of the CXC, CC, and C chemokine families through the conserved heparin-binding domains. The second myxoma protein, M-T1, also called CBP-II, is a member of a larger superfamily of poxvirus proteins that includes related secreted 35- kDa proteins encoded by a wide variety of orthopoxviruses. Deletion analysis of either CBP-I or -II genes within recombinant poxvirus constructs revealed profound alterations in the trafficking of infiltrating leukocytes into virus-infected lesions. It is proposed that the interaction of CBP-I with the conserved heparin-binding domains found on most chemokines represents a novel mechanism for altering multiple chemokine functions in vivo. In summary, CBP- I and CBP-II are the first examples of secreted virus proteins that bind to multiple chemokine family members as part of a strategy to prevent the early phase of inflammatory cell migration into virus-infected tissues.

Original languageEnglish (US)
Pages (from-to)570-576
Number of pages7
JournalJournal of Leukocyte Biology
Volume62
Issue number5
StatePublished - Nov 1 1997
Externally publishedYes

Fingerprint

Poxviridae
Chemokines
Carrier Proteins
Proteins
Viruses
Heparin
Myxoma virus
C Chemokines
Orthopoxvirus
Interferon Receptors
CXC Chemokines
CC Chemokines
Myxoma
Genes
Cell Movement
Glycoproteins
Leukocytes
Cytokines
Rabbits

Keywords

  • Heparin binding
  • Immune evasion
  • Vaccinia

ASJC Scopus subject areas

  • Immunology
  • Cell Biology

Cite this

Secreted poxvirus chemokine binding proteins. / Lalani, Alshad S.; McFadden, Douglas.

In: Journal of Leukocyte Biology, Vol. 62, No. 5, 01.11.1997, p. 570-576.

Research output: Contribution to journalReview article

Lalani, Alshad S. ; McFadden, Douglas. / Secreted poxvirus chemokine binding proteins. In: Journal of Leukocyte Biology. 1997 ; Vol. 62, No. 5. pp. 570-576.
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