Seasonal and mood independence of low basal prolactin secretion in premenopausal women with seasonal affective disorder

R. A. Depue, P. Arbisi, M. R. Spoont, S. Krauss, A. Leon, Barbara Ainsworth

Research output: Contribution to journalArticle

29 Scopus citations

Abstract

To test hypotheses of opposing roles of dopamine and serotonin in prolactin secretion in seasonal affective disorder, the authors determined basal serum prolactin concentrations for premenopausal women, eight with and 14 without seasonal affective disorder, in late afternoon during the follicular phase of the menstrual cycle (and a subgroup during the luteal phase) in winter and summer. Despite their significantly higher Hamilton depression scale scores in winter than in summer, the patients had significantly lower prolactin concentrations than the control subjects in both seasons. These results suggest that low prolactin secretion may be a trait characteristic in seasonal affective disorder.

Original languageEnglish (US)
Pages (from-to)989-995
Number of pages7
JournalAmerican Journal of Psychiatry
Volume146
Issue number8
Publication statusPublished - 1989
Externally publishedYes

    Fingerprint

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Depue, R. A., Arbisi, P., Spoont, M. R., Krauss, S., Leon, A., & Ainsworth, B. (1989). Seasonal and mood independence of low basal prolactin secretion in premenopausal women with seasonal affective disorder. American Journal of Psychiatry, 146(8), 989-995.