Screening for cytotoxic activity of plants used in traditional medicine

Jean Chapuis, Bernard Sordat, Kurt Hostettmann

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

A total of 260 extracts have been prepared from 75 medicinal plant species collected in Africa, Panama and Mauritius. Three different concentrations of each extract have been screened in vitro for cytotoxic activity using a colorimetric assay to determine cell survival of human colon carcinoma Co115 cells. Fifteen plants showed ED50 values between 10.0 and 1.0 μg/ml but more significant activities were obtained in 11 (ED50 range 1.0-0.1 μg/ml) and 3 (ED50 range 0.1-0.01 μg/ml) plant specimens. Identification of new active substances may well be aided by pre-selecting plants known to be used empirically by traditional healers.

Original languageEnglish (US)
Pages (from-to)273-284
Number of pages12
JournalJournal of Ethnopharmacology
Volume23
Issue number2-3
DOIs
StatePublished - Jan 1 1988
Externally publishedYes

Fingerprint

Traditional Medicine
Mauritius
Panama
Medicinal Plants
Cell Survival
Colon
Carcinoma

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

Cite this

Screening for cytotoxic activity of plants used in traditional medicine. / Chapuis, Jean; Sordat, Bernard; Hostettmann, Kurt.

In: Journal of Ethnopharmacology, Vol. 23, No. 2-3, 01.01.1988, p. 273-284.

Research output: Contribution to journalArticle

Chapuis, Jean ; Sordat, Bernard ; Hostettmann, Kurt. / Screening for cytotoxic activity of plants used in traditional medicine. In: Journal of Ethnopharmacology. 1988 ; Vol. 23, No. 2-3. pp. 273-284.
@article{4ed16b0707884d63b672861271477ea6,
title = "Screening for cytotoxic activity of plants used in traditional medicine",
abstract = "A total of 260 extracts have been prepared from 75 medicinal plant species collected in Africa, Panama and Mauritius. Three different concentrations of each extract have been screened in vitro for cytotoxic activity using a colorimetric assay to determine cell survival of human colon carcinoma Co115 cells. Fifteen plants showed ED50 values between 10.0 and 1.0 μg/ml but more significant activities were obtained in 11 (ED50 range 1.0-0.1 μg/ml) and 3 (ED50 range 0.1-0.01 μg/ml) plant specimens. Identification of new active substances may well be aided by pre-selecting plants known to be used empirically by traditional healers.",
author = "Jean Chapuis and Bernard Sordat and Kurt Hostettmann",
year = "1988",
month = "1",
day = "1",
doi = "10.1016/0378-8741(88)90006-2",
language = "English (US)",
volume = "23",
pages = "273--284",
journal = "Journal of Ethnopharmacology",
issn = "0378-8741",
publisher = "Elsevier Ireland Ltd",
number = "2-3",

}

TY - JOUR

T1 - Screening for cytotoxic activity of plants used in traditional medicine

AU - Chapuis, Jean

AU - Sordat, Bernard

AU - Hostettmann, Kurt

PY - 1988/1/1

Y1 - 1988/1/1

N2 - A total of 260 extracts have been prepared from 75 medicinal plant species collected in Africa, Panama and Mauritius. Three different concentrations of each extract have been screened in vitro for cytotoxic activity using a colorimetric assay to determine cell survival of human colon carcinoma Co115 cells. Fifteen plants showed ED50 values between 10.0 and 1.0 μg/ml but more significant activities were obtained in 11 (ED50 range 1.0-0.1 μg/ml) and 3 (ED50 range 0.1-0.01 μg/ml) plant specimens. Identification of new active substances may well be aided by pre-selecting plants known to be used empirically by traditional healers.

AB - A total of 260 extracts have been prepared from 75 medicinal plant species collected in Africa, Panama and Mauritius. Three different concentrations of each extract have been screened in vitro for cytotoxic activity using a colorimetric assay to determine cell survival of human colon carcinoma Co115 cells. Fifteen plants showed ED50 values between 10.0 and 1.0 μg/ml but more significant activities were obtained in 11 (ED50 range 1.0-0.1 μg/ml) and 3 (ED50 range 0.1-0.01 μg/ml) plant specimens. Identification of new active substances may well be aided by pre-selecting plants known to be used empirically by traditional healers.

UR - http://www.scopus.com/inward/record.url?scp=0023822591&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023822591&partnerID=8YFLogxK

U2 - 10.1016/0378-8741(88)90006-2

DO - 10.1016/0378-8741(88)90006-2

M3 - Article

C2 - 3193790

AN - SCOPUS:0023822591

VL - 23

SP - 273

EP - 284

JO - Journal of Ethnopharmacology

JF - Journal of Ethnopharmacology

SN - 0378-8741

IS - 2-3

ER -