3 Citations (Scopus)

Abstract

We present a method to fabricate, assemble dope-coded biosensing particles, and demonstrate a scalable high throughput protein detection application. The coded biosensing particles (8 μm in diameter and 280 nm thick) are composed of biosensing/coding/magnetic/adhesive layers and coded via patterned boron doping. Coding via doping is powerful in that it can be easily decoded, permits scalability of bit sizes down to tens of nanometers, generates a large number of codes, and retains uniform particle size and shape independent of particle code for consistent protein analysis. Following suspension phase protein binding, the dope-coded biosensing particles are extracted with an external magnet and analyzed with an atomic force microscope.

Original languageEnglish (US)
Article number043901
Pages (from-to)1-3
Number of pages3
JournalApplied Physics Letters
Volume88
Issue number4
DOIs
StatePublished - 2006

Fingerprint

proteins
coding
adhesives
boron
magnets
microscopes

ASJC Scopus subject areas

  • Physics and Astronomy (miscellaneous)

Cite this

Scalable dope-coded biosensing particles for protein detection. / Ly, Nguyen; Tao, Nongjian.

In: Applied Physics Letters, Vol. 88, No. 4, 043901, 2006, p. 1-3.

Research output: Contribution to journalArticle

@article{5dd8d1921b224f12a3ca73cda59f2fde,
title = "Scalable dope-coded biosensing particles for protein detection",
abstract = "We present a method to fabricate, assemble dope-coded biosensing particles, and demonstrate a scalable high throughput protein detection application. The coded biosensing particles (8 μm in diameter and 280 nm thick) are composed of biosensing/coding/magnetic/adhesive layers and coded via patterned boron doping. Coding via doping is powerful in that it can be easily decoded, permits scalability of bit sizes down to tens of nanometers, generates a large number of codes, and retains uniform particle size and shape independent of particle code for consistent protein analysis. Following suspension phase protein binding, the dope-coded biosensing particles are extracted with an external magnet and analyzed with an atomic force microscope.",
author = "Nguyen Ly and Nongjian Tao",
year = "2006",
doi = "10.1063/1.2166700",
language = "English (US)",
volume = "88",
pages = "1--3",
journal = "Applied Physics Letters",
issn = "0003-6951",
publisher = "American Institute of Physics Publising LLC",
number = "4",

}

TY - JOUR

T1 - Scalable dope-coded biosensing particles for protein detection

AU - Ly, Nguyen

AU - Tao, Nongjian

PY - 2006

Y1 - 2006

N2 - We present a method to fabricate, assemble dope-coded biosensing particles, and demonstrate a scalable high throughput protein detection application. The coded biosensing particles (8 μm in diameter and 280 nm thick) are composed of biosensing/coding/magnetic/adhesive layers and coded via patterned boron doping. Coding via doping is powerful in that it can be easily decoded, permits scalability of bit sizes down to tens of nanometers, generates a large number of codes, and retains uniform particle size and shape independent of particle code for consistent protein analysis. Following suspension phase protein binding, the dope-coded biosensing particles are extracted with an external magnet and analyzed with an atomic force microscope.

AB - We present a method to fabricate, assemble dope-coded biosensing particles, and demonstrate a scalable high throughput protein detection application. The coded biosensing particles (8 μm in diameter and 280 nm thick) are composed of biosensing/coding/magnetic/adhesive layers and coded via patterned boron doping. Coding via doping is powerful in that it can be easily decoded, permits scalability of bit sizes down to tens of nanometers, generates a large number of codes, and retains uniform particle size and shape independent of particle code for consistent protein analysis. Following suspension phase protein binding, the dope-coded biosensing particles are extracted with an external magnet and analyzed with an atomic force microscope.

UR - http://www.scopus.com/inward/record.url?scp=31544458979&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=31544458979&partnerID=8YFLogxK

U2 - 10.1063/1.2166700

DO - 10.1063/1.2166700

M3 - Article

AN - SCOPUS:31544458979

VL - 88

SP - 1

EP - 3

JO - Applied Physics Letters

JF - Applied Physics Letters

SN - 0003-6951

IS - 4

M1 - 043901

ER -