Satiety Does Not Alter the Ventral Striatum’s Response to Immediate Reward in Bulimia Nervosa

Amanda Bischoff-Grethe, Christina E. Wierenga, Ursula F. Bailer, Samuel M. MCClure, Walter H. Kaye

Research output: Contribution to journalArticlepeer-review

Abstract

Individuals with bulimia nervosa (BN) cycle between periods of binge-eating and compensatory behavior and periods of dietary restraint, suggesting extremes of under and overcontrol that may be metabolic-state related. This study examined the influence of hunger and satiety on impulsivity and neural responding during Twenty-three women remitted from BN (RBN) and 20 healthy comparison women (CW) performed a delay discounting task after a 16-hr fast and following a standardized meal during functional neuroimaging. A dual-systems approach examined reward valuation (decision trials where the early reward option was available immediately) and cognitive control (all decision trials). Interactions of Group 3 Visit (Hungry, Fed) for immediate had greater activation when hungry versus fed in the ventral striatum and dorsal had greater response when fed versus hungry in the dorsal caudate. Compared to CW, RBN showed decreased response when hungry within the left dorsal caudate and ventral striatum and increased response when fed in bilateral dorsal caudate. No differences were found within cognitive control regions or sensitivity is normally increased when hungry and decreased when fed; our findings support of hunger-based reward sensitivity within the striatum. However, RBN showed no differences for hunger and satiety in the ventral striatum and greater activation in the dorsal caudate when fed compared to hungry. This suggests RBN may be less sensitive to reward when hungry but do not reward when satiated, indicating altered metabolic modulation of self-regulatory control.

Original languageEnglish (US)
Pages (from-to)862-874
Number of pages13
JournalJournal of Abnormal Psychology
Volume130
Issue number8
DOIs
StatePublished - 2021
Externally publishedYes

Keywords

  • bulimia nervosa
  • dorsal caudate
  • fMRI
  • impulsivity
  • ventral striatum

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

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