SAMD9 is an innate antiviral host factor with stress response properties that can be antagonized by poxviruses

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

We show that SAMD9 is an innate host antiviral stress response element that participates in the formation of antiviral granules. Poxviruses, myxoma virus and vaccinia virus specifically, utilize a virus-encoded host range factor(s), such as a member of the C7L superfamily, to antagonize SAMD9 to prevent granule formation in a eukaryotic initiation factor 2α (eIF2α)-independent manner. When SAMD9 is stimulated due to failure of the viral antagonism during infection, the resulting antiviral granules exhibit properties different from those of the canonical stress granules.

Original languageEnglish (US)
Pages (from-to)1925-1931
Number of pages7
JournalJournal of Virology
Volume89
Issue number3
DOIs
StatePublished - Jan 1 2015
Externally publishedYes

Fingerprint

Poxviridae
Antiviral Agents
granules
stress response
Myxoma virus
Eukaryotic Initiation Factor-2
Vaccinia virus
Host Specificity
Response Elements
response elements
host range
Viruses
Infection
viruses
infection

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

Cite this

SAMD9 is an innate antiviral host factor with stress response properties that can be antagonized by poxviruses. / Liu, Jia; McFadden, Douglas.

In: Journal of Virology, Vol. 89, No. 3, 01.01.2015, p. 1925-1931.

Research output: Contribution to journalArticle

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