Salivary nerve growth factor reactivity to acute psychosocial stress: A new frontier for stress research

Heidemarie K. Laurent, Sean M. Laurent, Douglas A. Granger

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Objective: Neurotrophins such as nerve growth factor (NGF) may represent a stress-responsive system complementing the better known neuroendocrine (hypothalamic-pituitary-adrenal axis) and autonomic nervous system, but there is little evidence for NGF response to acute stress in humans because noninvasive measures have not been available. We investigated salivary NGF (sNGF) in 40 healthy young adults confronting a romantic conflict stressor. Methods: Five saliva samples - two collected before and three after the conflict - were assayed for sNGF, cortisol (hypothalamic-pituitary-adrenal marker), and α-amylase (sAA; ANS marker). In addition, a control group (n = 20) gave saliva samples at the same time intervals to determine whether sNGF changes were specific to the conflict stressor. Results: sNGF showed significant reactivity from entry to the first poststress sample among study participants (β = .13, p = .001), with nonsignificant change across poststress samples. Control participants showed no change in sNGF across the same period. Within-person changes in sNGF were generally aligned with both cortisol (β = .17, p = .003) and sAA (β = .17, p = .021) responses. Preconflict negative emotion predicted lower sNGF reactivity (β = -.08, p = .009) and less alignment with sAA (β = -.09, p = .040), whereas positive emotion predicted less alignment with cortisol (β = -.10, p = .019). Conclusions: This study is the first to document sNGF as a marker that responds to stress in humans.

Original languageEnglish (US)
Pages (from-to)744-750
Number of pages7
JournalPsychosomatic Medicine
Volume75
Issue number8
DOIs
StatePublished - Oct 2013

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Nerve Growth Factor
Research
Hydrocortisone
Saliva
Emotions
Nerve
Reactivity
Autonomic Nervous System
Nerve Growth Factors
Cortisol
Amylases
Young Adult
Alignment
Emotion
Control Groups

Keywords

  • α-amylase
  • ANS
  • Cortisol
  • HPA
  • Nerve growth factor
  • Stress

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Applied Psychology
  • Arts and Humanities (miscellaneous)
  • Developmental and Educational Psychology

Cite this

Salivary nerve growth factor reactivity to acute psychosocial stress : A new frontier for stress research. / Laurent, Heidemarie K.; Laurent, Sean M.; Granger, Douglas A.

In: Psychosomatic Medicine, Vol. 75, No. 8, 10.2013, p. 744-750.

Research output: Contribution to journalArticle

Laurent, Heidemarie K. ; Laurent, Sean M. ; Granger, Douglas A. / Salivary nerve growth factor reactivity to acute psychosocial stress : A new frontier for stress research. In: Psychosomatic Medicine. 2013 ; Vol. 75, No. 8. pp. 744-750.
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