Abstract
Adversity experienced early in life has the potential to influence physical health later in life. The stress-health relation may be partially explained by stress-related effects on cardiovascular risk factors. This study explored links between individual differences in trait-like variation in the activity of the hypothalamic-pituitary-adrenal (HPA) axis with cardiovascular risk factors in children. 474 children (M age = 9.22 years; 54% female 83% Caucasian) were included in this study, in which cardiovascular risk was assessed using the following indices - triglycerides (TG), HDL-cholesterol (HDL-C), glucose (Glu); resting systolic and diastolic blood pressure, body mass index (BMI), waist-to-hip ratio, and % fat. Saliva samples were measured 3 times a day (waking, 30 min post-waking and bedtime) over 3 days (later assayed for cortisol). A latent trait cortisol (LTC) factor explained 43% of the variance in cortisol levels within and across days. Confirmatory factor analysis identified three cardiovascular risk factors: lipids (i.e., TG and HDL-C), blood pressure (i.e., systolic and diastolic), and body composition (i.e., BMI, Waist-to-hip ratio, and % fat). Lower salivary LTC was associated with higher lipids, higher blood pressure, and higher body composition. The findings further support the internal and external validity of the LTC construct, and may also advance our understanding of the link between interindividual differences in HPA axis activity and cardiovascular risk in middle childhood.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 110-118 |
| Number of pages | 9 |
| Journal | Psychoneuroendocrinology |
| Volume | 71 |
| DOIs | |
| State | Published - Sep 1 2016 |
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Keywords
- Blood pressure
- Body composition
- Latent trait cortisol (LTC)
- Lipids
- Middle childhood
- Toxic stress
ASJC Scopus subject areas
- Endocrinology
- Endocrinology, Diabetes and Metabolism
- Psychiatry and Mental health
- Biological Psychiatry
- Endocrine and Autonomic Systems
Cite this
Salivary latent trait cortisol (LTC) : Relation to lipids, blood pressure, and body composition in middle childhood. / Yeung, Ellen W.; Place, Rebecca; Gordish-Dressman, Heather; Visich, Paul; Hoffman, Eric; Walker, Sheila O.; Granger, Douglas A.
In: Psychoneuroendocrinology, Vol. 71, 01.09.2016, p. 110-118.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Salivary latent trait cortisol (LTC)
T2 - Relation to lipids, blood pressure, and body composition in middle childhood
AU - Yeung, Ellen W.
AU - Place, Rebecca
AU - Gordish-Dressman, Heather
AU - Visich, Paul
AU - Hoffman, Eric
AU - Walker, Sheila O.
AU - Granger, Douglas A.
PY - 2016/9/1
Y1 - 2016/9/1
N2 - Adversity experienced early in life has the potential to influence physical health later in life. The stress-health relation may be partially explained by stress-related effects on cardiovascular risk factors. This study explored links between individual differences in trait-like variation in the activity of the hypothalamic-pituitary-adrenal (HPA) axis with cardiovascular risk factors in children. 474 children (M age = 9.22 years; 54% female 83% Caucasian) were included in this study, in which cardiovascular risk was assessed using the following indices - triglycerides (TG), HDL-cholesterol (HDL-C), glucose (Glu); resting systolic and diastolic blood pressure, body mass index (BMI), waist-to-hip ratio, and % fat. Saliva samples were measured 3 times a day (waking, 30 min post-waking and bedtime) over 3 days (later assayed for cortisol). A latent trait cortisol (LTC) factor explained 43% of the variance in cortisol levels within and across days. Confirmatory factor analysis identified three cardiovascular risk factors: lipids (i.e., TG and HDL-C), blood pressure (i.e., systolic and diastolic), and body composition (i.e., BMI, Waist-to-hip ratio, and % fat). Lower salivary LTC was associated with higher lipids, higher blood pressure, and higher body composition. The findings further support the internal and external validity of the LTC construct, and may also advance our understanding of the link between interindividual differences in HPA axis activity and cardiovascular risk in middle childhood.
AB - Adversity experienced early in life has the potential to influence physical health later in life. The stress-health relation may be partially explained by stress-related effects on cardiovascular risk factors. This study explored links between individual differences in trait-like variation in the activity of the hypothalamic-pituitary-adrenal (HPA) axis with cardiovascular risk factors in children. 474 children (M age = 9.22 years; 54% female 83% Caucasian) were included in this study, in which cardiovascular risk was assessed using the following indices - triglycerides (TG), HDL-cholesterol (HDL-C), glucose (Glu); resting systolic and diastolic blood pressure, body mass index (BMI), waist-to-hip ratio, and % fat. Saliva samples were measured 3 times a day (waking, 30 min post-waking and bedtime) over 3 days (later assayed for cortisol). A latent trait cortisol (LTC) factor explained 43% of the variance in cortisol levels within and across days. Confirmatory factor analysis identified three cardiovascular risk factors: lipids (i.e., TG and HDL-C), blood pressure (i.e., systolic and diastolic), and body composition (i.e., BMI, Waist-to-hip ratio, and % fat). Lower salivary LTC was associated with higher lipids, higher blood pressure, and higher body composition. The findings further support the internal and external validity of the LTC construct, and may also advance our understanding of the link between interindividual differences in HPA axis activity and cardiovascular risk in middle childhood.
KW - Blood pressure
KW - Body composition
KW - Latent trait cortisol (LTC)
KW - Lipids
KW - Middle childhood
KW - Toxic stress
UR - http://www.scopus.com/inward/record.url?scp=84973300221&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84973300221&partnerID=8YFLogxK
U2 - 10.1016/j.psyneuen.2016.05.013
DO - 10.1016/j.psyneuen.2016.05.013
M3 - Article
AN - SCOPUS:84973300221
VL - 71
SP - 110
EP - 118
JO - Psychoneuroendocrinology
JF - Psychoneuroendocrinology
SN - 0306-4530
ER -