Salivary biomarker levels and diurnal variation: Associations with medications prescribed to control children's problem behavior

Leah C. Hibel, Douglas A. Granger, Dante Cicchetti, Fred Rogosch

Research output: Contribution to journalArticle

53 Scopus citations


This study examined associations between medications prescribed to control children's problem behaviors and levels of, and diurnal variation in, salivary cortisol (C), testosterone (T), and dehydroepiandrosterone (DHEA). Saliva was collected in the morning, midday, and afternoon from 432 children ages 6-13 years. Relative to a no-medication comparison group, children taking (1) antipsychotics had higher DHEA levels and flat C diurnal rhythms, (2) Ritalin® or Adderall® had flat T diurnal rhythms, (3) Concerta® had higher T and DHEA levels, (4) antidepressants had flat DHEA diurnal rhythms, and (5) hypotensives had flat DHEA diurnal rhythms and higher T levels. Medications prescribed to control children's problem behaviors should be monitored in studies of the endocrine correlates and consequences of developmental psychopathology.

Original languageEnglish (US)
Pages (from-to)927-937
Number of pages11
JournalChild development
Issue number3
StatePublished - May 1 2007


ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Education
  • Developmental and Educational Psychology

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