Roles of Heat Shock Factor 1 in Neuronal Response to Fetal Environmental Risks and Its Relevance to Brain Disorders

Kazue Hashimoto-Torii, Masaaki Torii, Mitsuaki Fujimoto, Akira Nakai, Rachid ElFatimy, Valerie Mezger, Min J. Ju, Seiji Ishii, Shih-Hui Chao, Kristen J. Brennand, Fred H. Gage, Pasko Rakic

Research output: Contribution to journalArticle

57 Citations (Scopus)

Abstract

Prenatal exposure of the developing brain to various environmental challenges increases susceptibility tolate onset of neuropsychiatric dysfunction; still, the underlying mechanisms remain obscure. Here we show that exposure of embryos to a variety of environmental factors such as alcohol, methylmercury, and maternal seizure activates HSF1 in cerebral cortical cells. Furthermore, Hsf1 deficiency in the mouse cortex exposed in utero to subthreshold levels of these challenges causes structural abnormalities and increases seizure susceptibility after birth. In addition, we found that human neural progenitor cells differentiated from induced pluripotent stem cells derived from schizophrenia patients show higher variability in the levels of HSF1 activation induced by environmental challenges compared to controls. We propose that HSF1 plays a crucial role in the response of brain cells to prenatal environmental insults and may be a key component in the pathogenesis of late-onset neuropsychiatric disorders.

Original languageEnglish (US)
Pages (from-to)560-572
Number of pages13
JournalNeuron
Volume82
Issue number3
DOIs
StatePublished - May 7 2014

Fingerprint

Brain Diseases
Shock
Seizures
Hot Temperature
Induced Pluripotent Stem Cells
Brain
Schizophrenia
Stem Cells
Embryonic Structures
Alcohols
Mothers
Parturition
Late Onset Disorders

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Hashimoto-Torii, K., Torii, M., Fujimoto, M., Nakai, A., ElFatimy, R., Mezger, V., ... Rakic, P. (2014). Roles of Heat Shock Factor 1 in Neuronal Response to Fetal Environmental Risks and Its Relevance to Brain Disorders. Neuron, 82(3), 560-572. https://doi.org/10.1016/j.neuron.2014.03.002

Roles of Heat Shock Factor 1 in Neuronal Response to Fetal Environmental Risks and Its Relevance to Brain Disorders. / Hashimoto-Torii, Kazue; Torii, Masaaki; Fujimoto, Mitsuaki; Nakai, Akira; ElFatimy, Rachid; Mezger, Valerie; Ju, Min J.; Ishii, Seiji; Chao, Shih-Hui; Brennand, Kristen J.; Gage, Fred H.; Rakic, Pasko.

In: Neuron, Vol. 82, No. 3, 07.05.2014, p. 560-572.

Research output: Contribution to journalArticle

Hashimoto-Torii, K, Torii, M, Fujimoto, M, Nakai, A, ElFatimy, R, Mezger, V, Ju, MJ, Ishii, S, Chao, S-H, Brennand, KJ, Gage, FH & Rakic, P 2014, 'Roles of Heat Shock Factor 1 in Neuronal Response to Fetal Environmental Risks and Its Relevance to Brain Disorders', Neuron, vol. 82, no. 3, pp. 560-572. https://doi.org/10.1016/j.neuron.2014.03.002
Hashimoto-Torii, Kazue ; Torii, Masaaki ; Fujimoto, Mitsuaki ; Nakai, Akira ; ElFatimy, Rachid ; Mezger, Valerie ; Ju, Min J. ; Ishii, Seiji ; Chao, Shih-Hui ; Brennand, Kristen J. ; Gage, Fred H. ; Rakic, Pasko. / Roles of Heat Shock Factor 1 in Neuronal Response to Fetal Environmental Risks and Its Relevance to Brain Disorders. In: Neuron. 2014 ; Vol. 82, No. 3. pp. 560-572.
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