Role of the prelimbic subregion of the medial prefrontal cortex in acquisition, extinction, and reinstatement of cocaine-conditioned place preference

Arturo R. Zavalla, Suzanne M. Weber, Heather J. Rice, Andrea T. Alleweireldt, Janet Neisewander

Research output: Contribution to journalArticle

64 Citations (Scopus)

Abstract

Previous research suggests that the prelimbic subregion of the medial prefrontal cortex (mPFC) is necessary for acquisition of cocaine-conditioned place preference (CPP). Recently, it has been shown that extinguished cocaine-CPP can be reinstated by cocaine priming injections, and that this effect reflects the incentive motivational effects of the cocaine prime. To determine whether the prelimbic cortex is necessary for cocaine-reinstated CPP, rats received bilateral infusions of quinolinic acid (lesion group) or vehicle (sham group) into the prelimbic cortex and were later tested for acquisition, extinction, and reinstatement of cocaine-CPP. Both sham and lesion rats exhibited robust CPP established by systemic injections of cocaine (15 mg/kg, ip) following either one or three drug-environment pairings. Following repeated exposure to the cocaine- and saline-paired environments, sham and lesion rats showed similar rates of extinction of cocaine-CPP. In contrast, reinstatement of cocaine-CPP by cocaine priming injections (5 and 10 mg/kg, ip) was attenuated in rats with prelimbic cortex lesions relative to sham controls. This finding suggests that the prelimbic cortex is involved in the incentive motivational effects of cocaine priming.

Original languageEnglish (US)
Pages (from-to)157-164
Number of pages8
JournalBrain Research
Volume990
Issue number1-2
DOIs
StatePublished - Nov 14 2003

Fingerprint

Prefrontal Cortex
Cocaine
Injections
Psychological Extinction
Motivation
Quinolinic Acid

Keywords

  • Cocaine
  • Conditioned place preference
  • Incentive motivation
  • Prefrontal cortex
  • Prelimbic cortex
  • Reinstatement

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Role of the prelimbic subregion of the medial prefrontal cortex in acquisition, extinction, and reinstatement of cocaine-conditioned place preference. / Zavalla, Arturo R.; Weber, Suzanne M.; Rice, Heather J.; Alleweireldt, Andrea T.; Neisewander, Janet.

In: Brain Research, Vol. 990, No. 1-2, 14.11.2003, p. 157-164.

Research output: Contribution to journalArticle

Zavalla, Arturo R. ; Weber, Suzanne M. ; Rice, Heather J. ; Alleweireldt, Andrea T. ; Neisewander, Janet. / Role of the prelimbic subregion of the medial prefrontal cortex in acquisition, extinction, and reinstatement of cocaine-conditioned place preference. In: Brain Research. 2003 ; Vol. 990, No. 1-2. pp. 157-164.
@article{0a4ffdede9694fa49d36a8b3aac74d06,
title = "Role of the prelimbic subregion of the medial prefrontal cortex in acquisition, extinction, and reinstatement of cocaine-conditioned place preference",
abstract = "Previous research suggests that the prelimbic subregion of the medial prefrontal cortex (mPFC) is necessary for acquisition of cocaine-conditioned place preference (CPP). Recently, it has been shown that extinguished cocaine-CPP can be reinstated by cocaine priming injections, and that this effect reflects the incentive motivational effects of the cocaine prime. To determine whether the prelimbic cortex is necessary for cocaine-reinstated CPP, rats received bilateral infusions of quinolinic acid (lesion group) or vehicle (sham group) into the prelimbic cortex and were later tested for acquisition, extinction, and reinstatement of cocaine-CPP. Both sham and lesion rats exhibited robust CPP established by systemic injections of cocaine (15 mg/kg, ip) following either one or three drug-environment pairings. Following repeated exposure to the cocaine- and saline-paired environments, sham and lesion rats showed similar rates of extinction of cocaine-CPP. In contrast, reinstatement of cocaine-CPP by cocaine priming injections (5 and 10 mg/kg, ip) was attenuated in rats with prelimbic cortex lesions relative to sham controls. This finding suggests that the prelimbic cortex is involved in the incentive motivational effects of cocaine priming.",
keywords = "Cocaine, Conditioned place preference, Incentive motivation, Prefrontal cortex, Prelimbic cortex, Reinstatement",
author = "Zavalla, {Arturo R.} and Weber, {Suzanne M.} and Rice, {Heather J.} and Alleweireldt, {Andrea T.} and Janet Neisewander",
year = "2003",
month = "11",
day = "14",
doi = "10.1016/S0006-8993(03)03452-8",
language = "English (US)",
volume = "990",
pages = "157--164",
journal = "Brain Research",
issn = "0006-8993",
publisher = "Elsevier",
number = "1-2",

}

TY - JOUR

T1 - Role of the prelimbic subregion of the medial prefrontal cortex in acquisition, extinction, and reinstatement of cocaine-conditioned place preference

AU - Zavalla, Arturo R.

AU - Weber, Suzanne M.

AU - Rice, Heather J.

AU - Alleweireldt, Andrea T.

AU - Neisewander, Janet

PY - 2003/11/14

Y1 - 2003/11/14

N2 - Previous research suggests that the prelimbic subregion of the medial prefrontal cortex (mPFC) is necessary for acquisition of cocaine-conditioned place preference (CPP). Recently, it has been shown that extinguished cocaine-CPP can be reinstated by cocaine priming injections, and that this effect reflects the incentive motivational effects of the cocaine prime. To determine whether the prelimbic cortex is necessary for cocaine-reinstated CPP, rats received bilateral infusions of quinolinic acid (lesion group) or vehicle (sham group) into the prelimbic cortex and were later tested for acquisition, extinction, and reinstatement of cocaine-CPP. Both sham and lesion rats exhibited robust CPP established by systemic injections of cocaine (15 mg/kg, ip) following either one or three drug-environment pairings. Following repeated exposure to the cocaine- and saline-paired environments, sham and lesion rats showed similar rates of extinction of cocaine-CPP. In contrast, reinstatement of cocaine-CPP by cocaine priming injections (5 and 10 mg/kg, ip) was attenuated in rats with prelimbic cortex lesions relative to sham controls. This finding suggests that the prelimbic cortex is involved in the incentive motivational effects of cocaine priming.

AB - Previous research suggests that the prelimbic subregion of the medial prefrontal cortex (mPFC) is necessary for acquisition of cocaine-conditioned place preference (CPP). Recently, it has been shown that extinguished cocaine-CPP can be reinstated by cocaine priming injections, and that this effect reflects the incentive motivational effects of the cocaine prime. To determine whether the prelimbic cortex is necessary for cocaine-reinstated CPP, rats received bilateral infusions of quinolinic acid (lesion group) or vehicle (sham group) into the prelimbic cortex and were later tested for acquisition, extinction, and reinstatement of cocaine-CPP. Both sham and lesion rats exhibited robust CPP established by systemic injections of cocaine (15 mg/kg, ip) following either one or three drug-environment pairings. Following repeated exposure to the cocaine- and saline-paired environments, sham and lesion rats showed similar rates of extinction of cocaine-CPP. In contrast, reinstatement of cocaine-CPP by cocaine priming injections (5 and 10 mg/kg, ip) was attenuated in rats with prelimbic cortex lesions relative to sham controls. This finding suggests that the prelimbic cortex is involved in the incentive motivational effects of cocaine priming.

KW - Cocaine

KW - Conditioned place preference

KW - Incentive motivation

KW - Prefrontal cortex

KW - Prelimbic cortex

KW - Reinstatement

UR - http://www.scopus.com/inward/record.url?scp=0141918791&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0141918791&partnerID=8YFLogxK

U2 - 10.1016/S0006-8993(03)03452-8

DO - 10.1016/S0006-8993(03)03452-8

M3 - Article

C2 - 14568340

AN - SCOPUS:0141918791

VL - 990

SP - 157

EP - 164

JO - Brain Research

JF - Brain Research

SN - 0006-8993

IS - 1-2

ER -