Abstract
Alzheimer's dis ease (AD) is a leading cause of mortality in the developed world with 70% risk attributable to genetics. The remaining 30% of AD risk is hypothesized to include environmental factors and 7 human lifestyle patterns. Environmental factors possibly include inorganic and organic hazards, exposure to toxic metals (aluminium, copper), pesticides (organochlorine and organophosphate insecticides), industrial chemicals (flame retardants) and air pollutants (particulate matter). Long term exposures to these l environmental contaminants together with bioaccumulation over an individual's life-time are speculated to induce neuroinflammation and neuropathology paving the way for developing AD. Epidemiologic associations between environmental contaminant exposures and AD are still limited. However, many in vitro and animal studies have identified toxic effects of environmental contaminants at the cellular level, revealing alterations of pathways and metabolisms associated with AD that warrant further investigations. This review provides an overview of in vitro, animal and epidemiological studies on the etiology of AD, highlighting available data supportive of the long hypothesized link between toxic environmental exposures and development of AD pathology.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 116-146 |
| Number of pages | 31 |
| Journal | Current Alzheimer Research |
| Volume | 12 |
| Issue number | 2 |
| State | Published - May 1 2015 |
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Keywords
- Adult-onset disease
- Alzheimer's disease
- Endocrine disruptors
- Environmental contaminants
- Metals
- Neuropathology
- Parkinson's disease
- Pesticides
- Synergistic effects
- Toxins
ASJC Scopus subject areas
- Neurology
- Clinical Neurology
Cite this
Role of environmental contaminants in the etiology of Alzheimer's disease : A review. / Yegambaram, Manivannan; Manivannan, Bhagyashree; Beach, Thomas G.; Halden, Rolf.
In: Current Alzheimer Research, Vol. 12, No. 2, 01.05.2015, p. 116-146.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Role of environmental contaminants in the etiology of Alzheimer's disease
T2 - A review
AU - Yegambaram, Manivannan
AU - Manivannan, Bhagyashree
AU - Beach, Thomas G.
AU - Halden, Rolf
PY - 2015/5/1
Y1 - 2015/5/1
N2 - Alzheimer's dis ease (AD) is a leading cause of mortality in the developed world with 70% risk attributable to genetics. The remaining 30% of AD risk is hypothesized to include environmental factors and 7 human lifestyle patterns. Environmental factors possibly include inorganic and organic hazards, exposure to toxic metals (aluminium, copper), pesticides (organochlorine and organophosphate insecticides), industrial chemicals (flame retardants) and air pollutants (particulate matter). Long term exposures to these l environmental contaminants together with bioaccumulation over an individual's life-time are speculated to induce neuroinflammation and neuropathology paving the way for developing AD. Epidemiologic associations between environmental contaminant exposures and AD are still limited. However, many in vitro and animal studies have identified toxic effects of environmental contaminants at the cellular level, revealing alterations of pathways and metabolisms associated with AD that warrant further investigations. This review provides an overview of in vitro, animal and epidemiological studies on the etiology of AD, highlighting available data supportive of the long hypothesized link between toxic environmental exposures and development of AD pathology.
AB - Alzheimer's dis ease (AD) is a leading cause of mortality in the developed world with 70% risk attributable to genetics. The remaining 30% of AD risk is hypothesized to include environmental factors and 7 human lifestyle patterns. Environmental factors possibly include inorganic and organic hazards, exposure to toxic metals (aluminium, copper), pesticides (organochlorine and organophosphate insecticides), industrial chemicals (flame retardants) and air pollutants (particulate matter). Long term exposures to these l environmental contaminants together with bioaccumulation over an individual's life-time are speculated to induce neuroinflammation and neuropathology paving the way for developing AD. Epidemiologic associations between environmental contaminant exposures and AD are still limited. However, many in vitro and animal studies have identified toxic effects of environmental contaminants at the cellular level, revealing alterations of pathways and metabolisms associated with AD that warrant further investigations. This review provides an overview of in vitro, animal and epidemiological studies on the etiology of AD, highlighting available data supportive of the long hypothesized link between toxic environmental exposures and development of AD pathology.
KW - Adult-onset disease
KW - Alzheimer's disease
KW - Endocrine disruptors
KW - Environmental contaminants
KW - Metals
KW - Neuropathology
KW - Parkinson's disease
KW - Pesticides
KW - Synergistic effects
KW - Toxins
UR - http://www.scopus.com/inward/record.url?scp=84924918312&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84924918312&partnerID=8YFLogxK
M3 - Article
VL - 12
SP - 116
EP - 146
JO - Current Alzheimer Research
JF - Current Alzheimer Research
SN - 1567-2050
IS - 2
ER -