Role of B cells in vaccine-induced immunity against coccidioidomycosis

Dewey Magee, Rhonda L. Friedberg, Melanie D. Woitaske, Stephen Johnston, Rebecca A. Cox

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

We investigated secondary immunity against coccidioidomycosis by using gene expression microarrays. Surprisingly, a high percentage of B-cell-related genes were associated with protective immunity. A functional confirmation of the importance of B cells against coccidioidomycosis was achieved by demonstrating that vaccination was not fully protective in B-cell-deficient MuMT mice.

Original languageEnglish (US)
Pages (from-to)7011-7013
Number of pages3
JournalInfection and immunity
Volume73
Issue number10
DOIs
StatePublished - Oct 1 2005

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ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases

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